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The results show that all the hmgr genes from pigs, cattle and chickens are astable enzyme proteins with the same gene sequence characteristics and encoding protein and physical and chemical properties; all the amino acid sequences have a high degree of homology, containing two conservative HMG-CoA binding motifs and two NADPH binding motifs; all the amino acid sequences, containing signal peptide, are secreted proteins; they are all hydrophobic transmembrane proteins with five transmembrane domains; random coil and α-helix are the main structural elements in the HMGR polypeptide chain; all the predictions of three-dimensional structure are V- shaped; there are more closer evolution relationship between the HMGR gene from pigs and cattle.

结果表明:猪、牛和鸡HMGR基因序列特点及编码蛋白质理化性质基本相同,均属不稳定类酶蛋白;保守结构域氨基酸序列具有高度的同源性,均含有保守的2个β-羟基-β-甲基戊二酸单酰辅酶A结合基序和2个还原性烟酰胺腺嘌呤二核苷酸结合基序;均有信号肽,属分泌型蛋白质;属于跨膜的疏水性蛋白,均有5个跨膜结构域;无规则卷曲和α-螺旋是HMGR多肽链中的主要结构元件;三维结构预测都呈"V"字形;猪和牛HMGR基因的进化关系最近。

The main results are as follows.1. The UV-visible absorption spectra, the spin-trapping EPR measurements, and the DPA (9,10-diphenylanthracene) bleaching experiments showed that (1) HB-Net exhibits much improved light harvesting efficiency in the phototherapeutic window (600-900 nm) as the result of its remarkable absorption red shift with respect to HB;(2) HB-Net remains the generation abilities of semiquinone anion radical, superoxide anion radical, hydroxyl radical, and singlet oxygen, but with much lower efficiencies than that of HB, most likely due to its very short triplet excited state lifetime.

设计合成了寡聚吡咯酰胺修饰的竹红菌乙素衍生物HB-Net,利用紫外-可见吸收光谱、自旋捕获技术和DPA光漂白法详尽比较了HB-Net与HB的光动力性质,发现:(1) HB-Net的吸收光谱较HB有显著红移,在光疗窗口的吸光能力明显提高;(2) HB-Net能够产生半醌负离子自由基、超氧负离子自由基、羟基自由基和单重态氧,但由于其短的三重态寿命,这些活性物种的产生能力均弱于HB.2。

Within carboxylic groups, the coordination properties of carbonyl were studied and tn SEM graphs of picolinic acid, meta-methyl benzoic acid and 2-chloro-benzoic acid systems, a large amount of chains like structures probably caused by crystal growth have been firstly observed.

首次在杯[4]芳烃下沿羟基引进亲电性的三乙氧基硅基异腈酸丙酯,并且根据能量传递与匹配的机理合成了五种新型以改性超分子为功能片段的强键型杂化材料,其中与铽能量传递与发射情况最为优异。

In order to observe the capacity of composite artificial bone made from collage/Nano tricalcium phosphate conducting subperiosteal bone formation and investigate the possibility applied in reconstruction of astrophy aveolar ridge, the composite artificial bone was implanted into subperiosteum of the cranial bone in rabbits.

将胶原与纳米磷酸三钙复合制成复合人工骨并植入兔颅骨的骨膜下作为实验组,使用显微镜测微尺测量不同时间点新骨自骨表面长入材料内的高度,并和羟基磷灰石组作对照,观察 Co/N- TCP复合人工骨引导成骨能力,探讨其用于萎缩性牙槽嵴重建的可行性。

Traditional hydroxyapatite and tricalcium phosphate ceramics have not the potential of inducing bone regeneration. In order to endow them with this ability, bone tissue engineering has been established in recent years.

但是,传统的羟基磷灰石和磷酸三钙等生物陶瓷不具有诱导骨组织再生的功能,为赋予其诱导骨组织再生的生物功能,发展了骨组织工程。

OBJECTIVE: To test the performance of bone cement prepared with compound power containing α-tricalcium phosphate and hydroxylapatite and hardening liquid containing chitosan and citric acid as well as gelatin.

目的:检测在柠檬酸中添加壳聚糖、明胶配制的固化液与α-磷酸三钙和羟基磷灰石复合的粉剂调和制备骨水泥试样的性能。

The results show that the three kinds of sulfated fucans all had significant scavenging effects on free radicals.

结 果显示:(1)三种岩藻聚糖硫酸酯组分均有清除活性氧自由基的能力,但清除超氧阴离子自由基的能力高于清除羟基自由基的能力。

DATA SYNTHESIS: The collected data were categorized into 3 parts to discuss the general attributes of hydroxyapatite, triealeium phosphate and calcium phosphate bone cement, their application foreground in the treatment of the osteomylitis, the advantages and shortcomings of the carrier, and the release kinetic characteristics.

资料综合:对收集的文献按3个部分进行归类,分别介绍羟基磷灰石、磷酸三钙、磷酸钙骨水泥的属性、治疗骨髓炎的应用前景、载体的优缺点和其释药动力学特性。

Methods Glucose oxidase acted on saliva glucose,the generated hydrogen peroxide was measured by use of peroxidase with 2,4,6-tribromo-3 hydroxybenzoic acid and 4-aminoantipyrene to give a pink product that absorbed maximally at 510nm.

方法用2,4,6-三溴-3-羟基苯甲酸取代葡萄糖氧化酶测定法的苯酚,用于唾液葡萄糖的测定。并观察正常人与糖尿病患者血糖浓度和唾液葡萄糖含量之间的关系。结果186例健康人晨空腹唾液葡萄糖浓度为8.14±1.78mg/L。

Densities of glycine in glucose-water and sucrose-water mixed solvents have been measured to 298.15 K by an oscillating-tube densimeter. Apparent molar volumes, limiting partial molar volumes and number of hydration of glycine have been calculated. The transfer volumes from water to sugar-water mixtures have been obtained and discussed in terms of the structural hydration interaction model.

利用精密数字密度计测定了甘氨酸与不同组成葡萄糖-水、蔗糖、水混合溶剂构成的三元系溶液的密度,计算了甘氨酸的表观摩尔体积、极限偏摩尔体积和理论水化数,根据结构水合作用模型讨论了迁移偏摩尔体积的变化规律,并与乙二醇-水和丙三醇-水等多羟基体系作了比较。

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