三羟基的

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

During the manufacturing of the critical intermediate cephalosporin nucleus --7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt, first the feasibility of the one-pot synthetic route of open loop, closed loop and ozonization when chlorine is passed over is qualified by experiments. Then the critical factors that will influence this reaction are studied as follows: the mol ratio of triphenyl phosphite and Diphenylmethyl 3-hydroxy-7-phenylacetaminoceph-3-em-4-carboxylate-l-oxide is four to one; the quantity of the stablizer should be at least more than two to one. The temperature of the system must be 25℃ when chlorine is passed over so that the hydrochloride can be precipitated to obtain cephalosporin nucleus of cefaclor--7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt.

在制备关键中间体头孢母核7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐时，先通过实验验证把开环、闭环、臭氧化三步在通入氯气时并为一锅煮的合成路线的可行性之外，又研究了影响该反应的几个重要因素：亚磷酸三苯酯与3-羟基-7-头孢烷-5-亚砜-2-甲酸二苯甲酯的摩尔比为4：1；稳定剂2-甲基-2-丁烯的用量至少大于2：1，通入氯化氢气体时体系温度在25℃时盐酸盐则能够顺利析出，获得头孢克洛的头孢母核—7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐。

With trimethyl,4-dodecylbenezyl ammonium chloride and 18-crown-6 as pase-transfer catalysts, the azidation of polyepichlorohydrin in poly and H2O were studied. The reaction discipline and mechanism were discussed. The results show that the system with trimethyl, 4-dodecylbenezyl ammonium chloride as phase transfer catalyst and PEG as medium is a safe and effective approach to glycidyl azide polymer preparation, and azidational ratio of PECH can reach 97% above within 15 h.

研究了氯化十二烷基苄基三甲基铵和18-冠－6为相转移催化剂时端羟基聚环氧氯丙烷在聚环氧乙烷和水为介质中的叠氮化反应，探讨了反应规律和反应机理，结果表明：以PECH为介质，十二烷基苄基三甲基氯化铵(TMDA-1)为相转移催化剂的反应体系，可在15h内使PECH叠氮化转化率达到97%以上，无主链断裂等副反应，是一条较为安全快速的制备叠氮粘合剂的方法。

There are four parts in this thesis, the main works of author are summarized and presented as follows:1. Multivariate curve resolution with alternating least squares and alternating trilinear decomposition are applied in the resolution of overlapping peaks of camptothecin and 7-ethyl-10-hydroxy- camptothecin (SN-38) from HPLC-DAD.

全文共分四章，作者的主要工作有以下三个方面：一、采用HPLC-DAD检测，结合多元曲线分辨-交替最小二乘和交替三线性分解方法对未优化的色谱分离条件下产生的7-乙基-10-羟基喜树碱(SN-38)和喜树碱的严重重叠的色谱峰进行分辨。

Kinetic parameters, three dimensional structures and homogenous sequence alignment of evolved P450 BM3 E435T,D168H,D168NA225VK440N that can hydroxylate indole into indigo were compared to illustrate the molecular structural changes and mechanisms that improve catalytic properties.

通过动力学参数测定、同源序列比较以及三维结构的模建，对三个能够羟基化吲哚生成靛蓝的高活力P450BM3进化酶E435T，D168H，D168NA225VK440N所导致的酶分子结构变化和可能的活力提高机制进行了初步分析。

As we know, spiro-conjugated compound 1',3',3'-trimethyl-6-hydroxyspiro[2H-1-benzopyran-2,2'-indoline] is one of thesignificant photochromic species, the structure and spectrum ofthe compounds 1',3',3'-trimethyl-6- hydroxyspiro[2H-1-benzopyran-2,2'-indoline] and its isomers have studied.

三。研究了一类重要的光致变色物质之一螺旋共轭化合物1′，3′，3′-三甲基-6-羟基螺旋[2H-1-苯并吡喃-2，2'-二氢吲哚]及其光异构化产物的结构、光谱，并在此基础上，用完全态求和公式自编程序计算了非线性光学系数。

Pentanediol reacted with phosphorus tribromide to make it mono-bromination, under the catalytic action of PPTs it reacted with 2,3-dihydropyran to protect another hydroxy group, then to react with triphosphine, produced quarterphossal.

再以1，5-戊二醇为原料，三溴化磷使之单溴代，得到5-溴-1-戊醇，在对甲苯磺酸吡啶盐的催化下与2，3-二氢吡喃反应保护其另一端的羟基，与三苯基膦反应生成季磷盐。

There is disclosed a process for preparing sucralose by using monogroup protection. These researches included the following: 1. The method of using triethyl orthoacetate is an effective method of preparing sucrose 6-acylates for protection 6-position hydroxyl group.

本课题以单基团保护法合成三氯蔗糖，主要开展了以下几方面的研究： 1、原乙酸三甲酯法合成蔗糖-6-乙酸酯是保护6-位羟基有效的方法。

Because a part of hydroxyl group in methyl cellulose were substituted by trimethylsilyl group , the product could be dissolved in amounts of common organic solvents, such as chloroform, xylene and so on.

通过甲基纤维素与六甲基二硅亚胺的反应，成功地实现了对水溶性物质甲基纤维素醚三甲基硅化的改性；红外光谱验证了反应的发生，核磁共振氢谱确定了三甲基硅甲基纤维素的取代度；纤维素醚上的部分羟基被三甲基硅化后取得了在普通溶剂中的良好的溶解性，且随着取代度的增加，在非极性溶剂中的溶解性逐渐变好；通过热失重实验，对其热稳定性进行了测试。

Two types of three-arm or four-arm star-shapedPCL-b-D,L-PLGA50 copolymer with high molecular weight and narrow molecularweight distribution were synthesized via the block copolymerization of MG monomerwith star-shaped hydroxy-terminated PCL as macroinitiator and 〓 as catalyst.

以端羟基化的三臂或四臂星型PCL聚合物为大分子引发剂、〓为催化剂，引发MG单体的嵌段共聚合，合成了高分子量和窄分子量分布的三臂或四臂星型PCL-b-D，L-PLGA50共聚物。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新