三硫化合物

Fourth new aryl acyl ureas of triazole, tetrazole and thiodiazole have been synthesized.

合成了30个新的含三唑、四唑和噻二唑的芳酰基硫脲类化合物。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用"一勺烩"方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

A designed organic compound of triazine thiols monosodium was used for preparing polymeric film on pure copper by polymer plating .

通过有机镀膜的方法，利用一种自设计合成的三嗪硫醇化合物在铜表面制备有机薄膜。

A designed organic compound of triazine thiols monosodium was used for preparing polymeric film on pure copper by polymer plating.

通过有机镀膜的方法，利用一种自设计合成的三嗪硫醇化合物在铜。面制备有机薄膜。

With butyl xanthate as a collecter, the flotation behavior of jamesonite, pyrrhotite and marmatite, the depressing effects of small mercapto organic depressant (mercaptoacetic acid, mercaptoethanol ) and the effect of Cu2+ ion on depressing ability of mercapto compound were studied through flotation test and infrared spectrum.

摘 要：通过浮选实验、红外光谱测定，考察了脆硫锑铅矿、磁黄铁矿和铁闪锌矿在丁黄药作用下的浮选行为和巯基类小分子有机抑制剂对三种矿物的抑制效果以及Cu2+离子对巯基化合物抑制效果的影响。

A pentacarbonyl complex (3) isolatedfrom the same reaction from which the complex (1) is obtained, whose accuratestructure is yet known, is preliminarily studied.

对从含吡啶基团的二硫醇三齿配体与Fe_3_(12)的反应中得到的另一个准确结构有待确定的五羰基化合物(3)进行了初步的性质研究及表征。

Pyridoxine, pyridoxal , pyridoxamine as well as their phosphated forms are structural analogues in which pyridoxal-5"-phosphate and pyridoxamine-5"- phosphate are the biological active forms in vivo which act as the cofactors of aminotransferases, amino acid decarboxylases, cysteine desufbrase and cystathionine , etc by constant transconversions. Recently, it was discovered that B6 played a novel role in tumor growth suppression.

它包括三种结构十分近似的化合物：吡哆醇(Pyidoxine，PN)、吡哆醛(Pyridoxal，PL)和吡哆胺(Pyridoxamine，PM)，分别以磷酸化的形式发挥作用，其中吡哆醛-5'-磷酸(Pyridoxal-5'-phosphate，PLP)为B_6在体内的活性形式，通过与磷酸吡哆胺(Pyidoxamine-5-phosphate，PMP)的互变，作为多种酶(氨基转移酶、氨基酸脱羧酶、半胱氨酸脱硫酶、胱硫醚酶等)的辅酶而发挥传递基团的作用。

Chapter III We try to synthesizing pyrazole by hydrazine and thiourea in alkaline conditions, we found we can not get the acyl pyrazole in the conditions of synthesizing succinylthydrazine and ferrocenyl chalcone, pyrazole was got instead.

第三章我们尝试以酰肼及氨基硫脲作为氮源在碱性条件下来合成吡唑类化合物，并取得了理想的结果。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用&一勺烩&方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

The structural assignment of Ⅱwas supported by spectral data and was confirmed by the identification of the compound as the product obtained by synthesis from triethyl orthoacetate and 2- cyanot hioacetamide.

结构的指定得到由光谱数据的支持，确认结构是通过原乙酸三乙酯和2-氰基-硫代乙酰胺合成得到的化合物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。