丁炔

Nucleophilic opening of the terminalepoxide 57 by a lithium acetylide from 27 in the presence of BF3·EtO furnishedcompound 58, which had the skeleton of target molecule, subsequent conversionsinvolved the introduction of γlactone gave Annonacin.

然后以三氟化硼参与的炔负离子开环氧反应建立分子骨架，得到化合物58。随后经氢化，引入α，β不饱和丁内酯环、去保护等几步反应，就得到Annonacin。

Ingredients: Rose oil, rose fruit Oil, clove flower oil, deionized water, isopropyl myristate, glycerol, propylene glycol, polyethylene glycol -400, central PDMS, poly dimethyl siloxane, PDMS alcohol, polyacrylamide, C13-14 iso-paraffin, octoic acid / capric Acid Triglyceride, lauryl alcohol -7, hydroxyethyl acrylate, acryloyldimethyltaurate copolymer, squalane, poly sorbate esters -60, PEG-20 sorbitan laurate, panthenol, allantoin, methyl p-hydroxybenzoate, diazolidiny1 urea, 3-iodo-2-propynyl-butyl-carbamate, essence.

产品成分：玫瑰精油、玫瑰果油、丁香花油、去离子水、肉豆蔻酸异丙酯、甘油、丙二醇、聚乙二醇-400、环聚二甲基硅氧烷、聚二甲基硅氧烷、聚二甲基硅氧烷醇、聚丙烯酰胺、C13-14 异链烷烃、辛酸/癸酸甘油三酯、月桂醇醚-7、羟乙基丙烯酸酯、丙烯酰二甲基牛磺酸钠聚物、角鲨烷、聚山梨酸酯类-60、PEG-20 失水山梨醇月桂酸酯、泛醇、尿囊素、对羟基苯甲酸甲酯、双咪唑烷基脲、碘代丙炔基丁基甲氨酸酯、香精。

Aloe vera, Rosehip oil, Glycerin, Almond oil, Cetearyl wheat straw glycosides and cetearyl alcohol, Evening primrose oil, Jojoba oil, Glycerol stearate, Cocoa butter, Avocado oil, Carrot oil, Shea butter, Eyebright, Vitamin E, Grapefruit seed extract, Phenoxyenthanol, Iodopropynol butylcarbamate.

芦荟，野玫瑰果籽油，甘油，杏油，麦秸鲸蜡硬脂基葡糖苷和十六烷基醇，月见草油，霍霍巴油，甘油硬脂酸盐，可可脂，鳄梨油，胡萝卜油，牛油树脂，小米草，维生素E，葡萄籽精华素，苯氧乙醇，碘代丙炔基氨基甲酸丁

In the coupling reaction of 4 with 2-methyl-1-buten-3-yne the four- membered ring ligand is transferred to enyne to give the substituted eta3-butadienyl complex 5 containing the cyclobutenonyl group.

在4与2-甲基-3-炔-1-丁烯进行偶合反应后，四环结构仍然稳固存在，并转移到烯缺上形成一个含有四环结构的错合物5。

Water, Sweet almond oil, Cetearyl wheat bran glycosides and cetearyl alcohol, Hydrogenated jojoba oil, Zinc oxide, Rosehip oil, Evening primrose oil, Macadamia nut oil, Calendula oil, Honey, Camellia oil, Rose geranium oil, Frankincense oil, Lavender oil, Grapefruit seed extract, Vitamin E,marshmallow root,ginkgo bilboa, Phenoxyethanol, Iodopropynyl butylcarbonate.

水，甜杏油，麦秸鲸蜡硬脂基葡糖苷和十六烷基醇，氢化霍霍巴油，氧化锌，野玫瑰果籽油，月见草油，澳洲坚果油，金盏菊油，蜂蜜，山茶油，老鹳草玫瑰油，乳香油，薰衣草油，药属葵根，百果树，苯氧乙醇，碘代丙炔基氨基甲酸丁

Water, glycerin and glyceryl stearate SE, cetearyl wheat straw glycosides, cetearyl alcohol, rosehip oil, evening primrose oil, jojoba oil, almond oil, aloe vera, carrot oil, orange flower oil, grapefruit seed extract, vitamin e, chamomile oil, rose geranium oil, frankincense oil, lavendar oil, phenoxyethanol, iodopropynyl butylcarbamate

十六烷基醇，野玫瑰果籽油，月见草油，霍霍巴油，杏仁油，芦荟，胡萝卜油，橙花油，葡萄籽精华素，维生素E，甘菊油，玫瑰老鹳草油，乳香油，熏衣草油，苯氧乙醇，碘代丙炔基氨基甲酸丁。

Purified water, Vegetable glycerine, Avocado oil, Cetearyl wheat straw glycosides and cetearyl alcohol, Vegetable glycoerol stearate, Evening primrose oil, Rosehip oil, Calendula oil, Vitamin E, Vitamin A palmitate, Green tea leaf extract, Ginkgo biloba extract, Grapefruit seed extract, 100% natural fragrance (essential oil blend of orange blossom, ylang ylang, rose, jasmine, tonka bean), phenoxyethnol, Iodopropynyl butylcarbamate.

纯水， 蔬菜甘油，鳄梨油，麦秸鲸蜡硬脂基葡糖苷和十六烷基醇，蔬菜银杏硬脂酸，月见草油，野玫瑰果籽油，金盏菊油，维生素E ，维生素A棕榈酸酯，绿茶叶提取物，银杏叶提取物，葡萄柚籽提取物， 100 ％天然香料（精油混合橘子的花，依兰依兰，玫瑰，茉莉花，零陵香豆），苯氧乙醇，碘代丙炔基氨基甲酸丁

The E-TOF will also be feasible and practical to assist chemists in screening the optimal reaction condition or evaluating the overall efficiency of different catalytic systems for a specific asymmetric reaction.4.For the first time,we explored chiralγ-hydroxy-α,β-acetylenic esters,which were prepared via asymmetric alkynylation,as key intermediates to the synthesis of chiralγ-butyrolactones. This convergent and enantioselective approach to chiralγ-butyrolactones is practical and easily handled with protecting group free.

这一概念包括反应产率、对映选择性、配体用量以及反应时间四个重要反应参数，不仅适用同一反应不同催化体系的横向综合性评价，而且适用于某一特定反应催化体系的优化过程，有助于研究人员选择最佳的反应条件。4、我们发展了以手性γ-羟基-α，β-炔酸酯为关键中间体完成了手性γ-丁内酯类天然产物的对映立体选择性全合成，该关键中间体能够以我们的催化体系方便的对映选择性合成，之后的官能团转换方法成熟，易于操作，无需进行繁琐的官能团保护和脱保护过程，绿色经济。

A method to synthsis a - methylene - r - butyrolactones was reported by the substituted (a - carbethoxyvinyl) cuprate intermediates, generated by the addition of higer order cuprate to acetylenic ester,traping with epoxides stereoselectively.

本文报道了通过以高序铜代替低序铜对炔酸酯加成得到的取代铜与端基或环状环氧化合物的立体选择性反应，较高产率的合成α，β-取代烯酯，进而可合成α-亚烷基-γ-丁内酯类衍生物。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新