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"This is an important point," Dr. Sawyers told Medscape in an interview,"as it shows that the drug target continues to mutate and that BCR-ABL is the escape mechanism." Hence, further drug development should continue to focus on BCR-ABL and not on any of the other mechanisms that are thought to also be involved, he commented.

Sawyers医师在一项访谈中向Medscape表示,这是个重点,当这项研究显示药物的标的持续在突变,且BCR-ABL基因有逃脱机转,他评论,之后的药物研发应该继续针对BCR-ABL且不应针对其他被认为牵涉其中的机转。

A general transcriptional factor for RNA polymerase II that binds to multiple promoter elements and specific transcription factors.

一种能与多个启动子元件和特异性转录因子结合的RNA聚合酶II通用转录因子。

A novel carbonyl transposition led by anilines'nucleophilic addition to methyl 2-keto α-D-glucopyranoside was discovered. And the mechanism of the reaction concerned to an enol rearrangment was provided through tracing the change of 〓H-NMR and 〓C-NMR of a hemiacetal intermediate which was obtained in the reaction of o-phenylene diamine with 2-keto glycoside. Both the intermediate and the converting product were identified by 〓H-NMR,〓C-NMR,〓H-〓H COSY and HMQC.

一、发现了2-位氧化α-甲基D-葡萄糖苷的芳胺亲核加成引起羰基转位的新方法,利用核磁共振氢谱及碳谱对邻苯二胺与2-位氧化α-甲基D-葡萄糖苷加成生成的稳定中间体半缩酮化合物在氘代丙酮中的变化进行跟踪,结合对转化产物的氢氢相关谱和HMQC结构确证,提出了该反应中2-位羰基通过烯醇化互变而转至3-位的机理并得到了验证。

You can interchange 1st line 2nd line to Longyang Lu Station interchange magnetic suspension trains.

您也可以一号线转乘二号线至龙阳路站,转乘磁悬浮列车。

Objective Nuclear factor kappa B is an important transcription factor that is involved in the response to oxidative stress and inflammation.

目的:核转录因子kappaB是一种与氧化应激反应、感染相关的重要转录因子。

If you've ever played an old LP record where the hole was not quite centered, you've heard the pitch rise and fall with each revolution.

要是你播放过老式慢转密纹唱片,你就能听到,当唱片的空穴没有置于唱机正中央,唱片每转一周,音乐都会有音调高低的变化。

The motor s physics process in the changing of magnetic store energy and mechanism and parameter calculation in the self inductance, mutual inductance, magnetic flux linkage and electromagnetism torque is discussed in such respect of multi return and electromagnetism torque theory.

从多电流互感回路理论出发,以电磁转矩这一机电耦合项为依据,讨论电机的磁场储能与机械能相互转换的物理过程、隐极电机的电流回路中自感和互感参数计算、磁链方程及电磁转矩计算

First it make a circle to the right, then to the left.

刚开始它向右转了一个圈,然后又向左转了一圈。

By the test of clonal growth in soft agar medium , we compared the ability of cloning and proliferating among these three kinds of cells. The cell cycle was analyzed by FCM and morphosis of cells was observed under transmission eletron microscope.

通过细胞生长曲线,比较卵巢癌细胞系HO-8910与8910-p93、8910一pCDNA3.1(转染空载体ncDNA3.l)的增殖情况;通过软琼脂克隆形成试验比较这3种细胞的克隆形成能力和增殖能力;利用流式细胞仪检测这3种细胞的细胞周期的改变情况:利用透射电镜观察转染p93基因的细胞的超微结构变化;利用裸鼠移植瘤实验比较HO七与8910个93在动物体内生长状况。

To move to messages from the previous day,in the message list,press P.To move to message from the next day,Press N.

在短信列表状态下,按p键可以转到当前短信的前一天短信列表,按N转到后一天的短信列表。

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For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降,而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新

Lao Qiu is the Chairman of China Qiuyang Translation Group and the head master of the Confucius School. He has committed himself to the research and promotion of the classics of China.

老秋先生为中国秋阳翻译集团的董事长和孔子商学院的院长,致力于国学的研究和推广。