一溴化的

Table 1 medical packaging materials, containers, scope of pharmaceutical packaging materials, containers, in the form of the name preparation notes plastic bottle kalidehydroandrogropholidi = 50ml material with PP, LDPE Infusion bags, kalidehydroandrogropholidi = 50ml material is PVC, polyalkene glass infusion bottle 50ml clorsulon = injection bottle kalidehydroandrogropholidi 50ml, kalidehydroandrogropholidi = 50ml-molded, control of glass bottle kalidehydroandrogropholidi kalidehydroandrogropholidi 50ml kalidehydroandrogropholidi 50ml ampule medical plastic bottle of tablets, capsules, tablets, colour.10pills glass ampoules, pills and capsules, syrup, oral solution, nanosuspensions, immunoembolization, tincture, linimentum, lotio hard PVC medicinal Tablet and capsule-plastic blister packaging PVC/PE/PVDC medicinal compound hard Tablet and capsule-plastic blister packaging Composite PVC/PVDC medicinal Tablet and capsule hard-plastic blister packaging cold metal forming hard medicinal compound tablets, capsules, suppository materials have nylon/aluminium/PVC double aluminum packaging Tablet and capsule PVC/hard LDPE medicinal compound tablets, capsules, suppository glass bottle ciinincal ciinincal ciinincal plastic bottle medicinal ciinincal medicinal eardrops plastic bottle eardrops medicinal nasal drops plastic bottle nose drops for external use liquid medicinal plastic bottle tincture, linimentum, lotio koufuye of medicinal plastic bottle syrup, oral solution, nanosuspensions, immunoembolization glass control oral bottle syrup, oral solution, nanosuspensions, immunoembolization packaging for medicine bag laminating film, puivis bletillae, feian and Tablet foil Tablet and capsule of unguentum Al fighting、smoke aluminium pipe, oculentum, puivis bletillae, Tin aerosolon, nabulization materials have aluminum, plastic valve pyritionate, nabulization stopple kalidehydroandrogropholidi 50ml, 50ml clorsulon = material bromide, CIIR synthesis of oprene 50ml clorsulon = gasket aluminium caps combination Cap koufuye falchion, kalidehydroandrogropholidi 50ml, 50ml prestrain kalidehydroandrogropholidi = potting needle kalidehydroandrogropholidi 50ml desiccant tablets, capsules, pills and aluminium bottles vinpocetione polyethylene film and bag vinpocetione b, package management and standards on the management of the drug packaging mainly has two modes: a mode of government management, such as Singapore, Indonesia adopted a market access system, United States, Canada, the European Union through the implementation of the medicine on the packaging of the strict management, that is, the drug registration, declare to use medical packaging of related materials; Government departments on the packaging manufacturer production system to carry out spot checks.

表1 药品包装材料、容器适用的范围药用包装材料、容器名称制剂形式备注塑料输液瓶注射剂≥50ml 材料有PP、LDPE 输液膜、袋注射剂≥50ml 材料有PVC、聚烯烃玻璃输液瓶注射剂≥50ml 冻干注射剂瓶注射剂0ml、注射剂≥50ml 模制、管制玻璃注射剂瓶注射剂0ml 安瓿注射剂0ml 口服固体药用塑料瓶片剂、胶囊、丸剂玻璃药瓶片剂、胶囊、丸剂、糖浆剂、口服溶液剂、混悬剂、乳剂、酊剂、搽剂、洗剂 PVC药用硬片片剂、胶囊铝塑泡罩包装 PVC/PE/PVDC药用复合硬片片剂、胶囊铝塑泡罩包装 PVC/PVDC药用复合硬片片剂、胶囊铝塑泡罩包装冷冲压成型药用复合硬片片剂、胶囊、栓剂材料有尼龙/铝/聚氯乙烯双铝包装片剂、胶囊 PVC/LDPE药用复合硬片片剂、胶囊、栓剂玻璃滴眼剂瓶滴眼剂药用滴眼剂塑料瓶滴眼剂药用滴耳剂塑料瓶滴耳剂药用滴鼻剂塑料瓶滴鼻剂外用液体药用塑料瓶酊剂、搽剂、洗剂口服液体药用塑料瓶糖浆剂、口服溶液剂、混悬剂、乳剂玻璃管制口服液瓶糖浆剂、口服溶液剂、混悬剂、乳剂药品包装用复合膜、袋散剂、颗粒剂、片剂药品包装用铝箔片剂、胶囊铝管、铝塑管软膏、眼膏剂、散剂、罐气雾剂、喷雾剂材料有铝、塑料阀门气雾剂、喷雾剂胶塞注射剂0ml、注射剂≥50ml 材料有溴化、氯化丁基橡胶合成聚异戊二烯垫片注射剂≥50ml 铝盖、铝塑组合盖口服液、注射剂0ml、注射剂≥50ml 预灌封注射针注射剂0ml 干燥剂片剂、胶囊、丸剂铝瓶原料药聚乙烯膜、袋原料药二、包装管理及标准各国对药品包装的管理主要有两种模式：一种模式是政府管理，如新加坡、印度尼西亚采取市场准入制的方式，美国、加拿大、欧盟通过对药品的管理实施对药品包装的严格管理即在药品注册时，申报所使用药品包装的相关材料；政府部门对药品包装生产企业的生产体系进行现场检查。

METHODS: Pulmonary function tests were performed in 20 children with asthmatoid bronchitis (2 months-2.5 years of age) before and 30, 60, and 120 minutes after salbutamo and ipratropium bromide inhalation. The indexes of pulmonary function measured included tidal breathing flow volume loop, percent of tidal volume to peak tidal expiratory flow, terminal flows per peak expiratory flow (25/PF), peak tidal expiratory flow, rate of mid-expiratory to mid-inspiratory flow, respiratory rate and tidal volume per kilogram. RESULTS: Before drug inhalation, the descending branch of the TBFV loop was depressed.

20例2个月至2岁6个月的喘息性支气管炎患儿，在吸入药物沙丁胺醇+溴化异丙托品前、吸入后30，60，120min各行一次潮气流速容量环检查，并进行肺功能各项指标比较，包括潮气呼吸流速容量环的形态，反映小气道功能的敏感指标到达潮气呼气峰流速时的呼气量/潮气量，呼出75%潮气量时的呼气流速/潮气呼气峰流速(25/PF)，潮气呼气峰流速，反映大气道功能的指标潮气呼气中期流速/潮气吸气中期流速，潮气呼吸状态下的通气功能，包括呼吸频率，每公斤体重潮气量。

Effect of different surfactants on the UV intensity of Al(superscript 3+)-MXFX have been studied. Is Cetyl Trimethy-lammonium Bromide can increase the UV intensity of Al(superscript 3+)-MXFX is discovered. Based on this reaction, the reaction conditions in detail and proposed a simple, rapid and sensitive new method for the determination of MXFX by UV method is inve stigated. This method has been applied for the determination of MXFX in tablet with satisfactory results.

通过研究不同表面活性剂对Al(上标 3+)-莫西沙星体系紫外特性的影响，发现十六烷基三甲基溴化铵对该体系有显著的增敏作用；系统研究了CTMAB-Al(上标 3+)-MXFX反应体系的紫外特性，利用这一反应体系，建立了简单、快速、灵敏的测定莫西沙星的紫外分光光度法，选择了最佳实验条件，并将此方法用于莫西沙星片剂的测定，结果满意。

Results The synthesis condition was improved. The method of methane sulfonic acid/DL-methionine was found an ideal substitute of BBr3 for less cost. While using hydrobromic acid, the O-demethylation and hydrolyzation could be combined in one stage.

结果 优化了纳洛酮的合成工艺，甲磺酸／DL-甲硫氨酸法试剂价格低廉，可降低生产成本；而氢溴酸法不但试剂价格更低，还可将去氧甲基化和水解合并为一步反应，使新工艺的总收率提高到59.90%，产品质量符合中国药典。

The synthesis of dimethyl fumarate was studied from maleic anhydride and methanol with phospho molybdic acid as the catalyst and bromate as the isomerization catalyst by one-step in this short paper.

采用固体杂多酸磷钼酸为催化剂，溴酸盐为异构化剂，经顺酐一步合成了富马酸二甲酯，探讨了醇酐比、反应时间、催化剂的量、异构化剂的量以及异构化时间对合成DMF收率的影响，并确立了最佳反应条件。

Fourthly, The preparation of 1 -triazolyl-2-isoxazolinyl substituted-ethenes was developed through an one-pot 1, 3-dipolar cycloaddition of NaN_3 and RI,α-alkylation reaction of substituted allyl bromides and 1, 3-dipolar cycloaddition of nitrile oxidesbased on polystyrene-supported propargyl selenide.

四、从聚苯乙烯负载的炔丙基硒醚出发，通过与叠氮化钠和碘化物的一锅法1，3-偶极环加成反应、取代烯丙基溴的α-烷基化反应和腈氧化物的1，3-偶极环加成反应固相合成了1—三唑—2—异噁唑啉取代的-乙烯。

The micelle shape transformation of tert-octylpheny phenol polyethylene glycol ether (TX-100), sodium dodecyl benzene sulfonate and tetradecyl trimethyl ammonium bromide in heavy water solutions was studied by 1H nuclear magnetic resonance spectroscopy, including an NMR self-diffusion experiment. These experiments showed that the surfactants formed several shapes of micelles (spherical, ellipsoidal, and rodlike) at the respective concentrations which were far above their critical micelle concentration.

运用核磁共振一维氢谱和自扩散实验方法研究了聚乙烯乙二醇异辛酚醚(TX-100)、十二烷基苯磺酸钠和十四烷基三甲基溴化铵三种不同类型的表面活性剂在重水溶液中的胶束形状转变，发现它们在临界胶束浓度以上的各自相应浓度都有胶束形状的变化（由球状转变为椭球状或棒状）。

The phosphorus oxychloride or phosphorus tribromide N, N-dimethylformamide mix and react to form the Vilsmeier reagent used in the reaction. The newly prepared Vilsmeier reagent is added into the reaction bottle provided with the return condenser and the blender; a reaction raw material N, N-dimethylformamide solution expressed in the reaction formula is added into the system; the temperature is risen; the corresponding multi substituting pyridine-2 (1 H)-ketone compound can be made after the column chromatography of the silica gel; the production rate is between 60 and 95 percent according to different reactions.

由三氯氧磷或三溴化磷N，N-二甲基甲酰胺混合获得反应中所用Vilsmeier试剂；将新配制的Vilsmeier试剂加入装有回流冷凝管、搅拌器的反应瓶中，向体系中加入反应通式中表示的一种反应原料的N，N-二甲基甲酰胺溶液，升温，经硅胶柱层析分离得相应的多取代吡啶-2(1H)-酮类化合物，产率视不同反应在60~95％之间。

In the fourth chapter , we studied the resonance light scattering spectral characteristic of patent blueⅤ- Cetyltrimethyl ammonium bromide-nucleic acid system, and the elementary reaction mechanism with absorption spectra method and 1H NMR spectra method. Another new determination method of nucleic acid at nanogram level was established.

第四章研究了五号专利兰-十六烷基三甲基溴化铵-核酸体系的共振散射光谱特征，并结合吸收光谱法、核磁共振光谱和一系列条件实验探讨了它们的作用机理，建立了一种测定纳克级核酸的新方法。

Monophenyltin trichloride reacts withdicarbonyl dicyclopentadienyl titanium immediately at room temperature, but no ti-tanium-tin complex produced, and the products were diphenyltin dichloride〓 and tin or stannous Chloride. When diaryltin dihalides were used, only the chlorides and bromides reacted with 〓form the complexes containing titaninm-tin bond,〓. but the corresponding iodide complex was not found. This reaction is Sensitive totemperature,when the temperature is belw 10℃,the reaction hardly takes place,but as the temperature is above 25℃,more 〓 will be found and the reactionbecome more complex.

Ph-SnC〓室温下即可与Cp〓迅速反应，但不生成含钛一锡链的化合物，而是生成Ph〓和Sn或Sn〓二芳基二卤化锡化物中，只有氯化物和溴化物才能和〓反应生成含钛〓锡键的化合物〓相应的碘化物则不行，而且反应对温度比较敏感，低于10℃，反应几乎不能进行，而高于25〓，则会生成更多的〓，在回流条件下得不到含钛〓锡键的化合物，只能得到分解产物，〓和Sn或〓。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。