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一氧化氮

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Objective: To study the influences of NOS inhibitor L-NNA on the releases of exitatory and inhibitory amino acids from rat striatums during persistent global ischemia.

目的:研究一氧化氮合成酶抑制剂对大鼠半球持续性缺血时兴奋性和抑制性氨基酸释放的影响。

Images, functions and histopathological characteristics of Oddi's sphincters of experimental groups were studied and compared with control group by cholangiography, catheter manometry, and quantitative analysis of nitric oxide synthase.

采用胆管造影,单腔管测压,一氧化氮合酶定量分析等方法,研究胆管 Oddi括约肌影像、功能及病理组织学的特征。

Organic phosphorus ; Intoxication ; Nitric oxide ; Endothelin ; Pulmonary edema

有机磷;中毒;一氧化氮;内皮素;肺水肿

Objective To investigate the effect of water-immersion restraint stress on nitric oxide production and its mechanism in rat platelets.

目的 观察急性应激对大鼠血小板一氧化氮释放的影响及其机制。

Methods Blood samples of fifty-two patients who underwe n t open heart surgery with CPB were collected from right internal jugular vein at p oints as pre-CPB, rewarming, aortic declamping, 6 hours and 24 hours after CPB. Cytokines, iNOS, S-100 and NSE were assayed accurately. In addition, its corre lation between them were also analysed.

方法于 CPB前、复温即刻、主动脉开放和 CPB后 6、2 4小时采集 5 2例心脏病患者颈内静脉血,检测 S- 10 0蛋白和 NSE的浓度,并将其与炎性细胞因子白细胞介素- 6 (IL- 6 )、白细胞介素- 8(IL- 8)、肿瘤坏死因子-α和诱导型一氧化氮合成酶的浓度变化进行相关性分析。

Methods: Twenty-four male SD rats were randomly divided into normal control (NC, n=6), protein C activator (PCA, n=6), lipopolysaccharide (LPS, n=6) and LPS+PCA group (n=6). NC group were given normal saline and PCA group were injected protein C activator (0.4 mg/kg) through vein of the tail. LPS group were administered lipopolysaccharide (10 mg/kg, 4h) by intraperitoneal injection method to make the model of septic shock rats. After the animal model was made, LPS+PCA group were injected protein C activator (0.4 mg/kg) through vein of the tail. 30 minutes after the injection, each rat was tested by Medlab biosignal analyzing system for observing mean arterial pressure and left ventricle function, the activity of LDH and iNOS in myocardium and the cuttings of myocardial tissues.

取SD雄性大鼠24只随机分成对照组、PCA组、LPS组和LPS+PCA组四组,对照组尾静脉注射生理盐水,PCA组尾静脉注射蝮蛇毒蛋白C激活物,LPS组腹腔注射LPS (10 mg/kg, 4h)的方法建立败血症休克的实验动物模型,在建立败血症的实验动物模型的基础上,尾静脉注射PCA (0.4 mg/kg)为LPS+PCA组,每只大鼠均于药后30 min时运用Medlab生物信号采集处理系统记录平均动脉压和左心室功能指标,并测定心肌中乳酸脱氢酶活性、诱导性一氧化氮合酶活性及心肌病理切片。

Objective To study the trend of Nitric Oxide level of serum during thrombolysis therapy by means of urokinase for patients with acute myocardial infarction and its clinical significance.

目的 探讨尿激酶溶栓治疗急性心肌梗死期间血清一氧化氮的动态变化和临床意义。

Objective:To investigate the effect of estrogen replacement therapy on the serum nitric oxide and endothelinl-1(ET-1) level of ovarie ctomized rat.

目的:观察雌激素替代治疗对去卵巢大鼠血清一氧化氮和内皮素-1(ET-1)水平的影响。

METHODS Dinitrofluorobenzene was used to induce the contact dermatitis in mouse ear, rhIL-11 0.375-1.5 mgkg^(-1)d^(-1) sc for 10 d, the degree of skin inflammatory reaction was observed. At the same time, the serum level of tumor necrosis factor-α and interleukin-6(IL-6) was measured by radioimmunoassay; the serum level of nitrogen monoxidum was detected by biochemical method and the expression of intercellular adhesion molecule-1(ICAM-1) was detected by immunohistochemical method.

采用2,4-二硝基氟苯致小鼠耳部皮肤接触性皮炎试验模型,观察sc rhIL-11 0.375~1.5mgkg^(-1)d^(-1),连续10d后皮肤炎症反应程度,同时采用放射免疫分析法测定血清中肿瘤坏死因子-α和白细胞介素-6(IL-6)的水平,采用生物化学检测法测定血清一氧化氮的水平,采用免疫组化法测定皮肤中细胞间粘附分子(ICAM-1)的表达。

Ocular crosssections were prepared for staining of HE and eyeball slicing parallel TUNEL staining. To observe the cell morphology of 4 groups RGCL.

眼球切片并行TUNEL染色和HE染色,观察4组RGCL的细胞形态,免疫组化染色观察诱生型一氧化氮合酶的表达。

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