-甲基哌啶

Objective: To observe the effect of quaternary ammonium salt derivation of haloperidol on coronary artery.

目的：观察氟哌啶醇季铵盐衍生物对冠状动脉的作用。

Objective To study the mechanism of synergistic analgesic action of haloperidol and morphine.

目的 研究氟哌啶醇与吗啡协同镇痛作用的机制。

However, pretreatment with CP-101,606 (1 mg/kg), a selective antagonist for the NR2B subunit of the N M D A receptor, significantly attenuated catalepsy and the expression of Fos-IR cells in the forebrain after the administration of haloperidol.

受体拮抗剂BD-1407 (3 mg/kg)and α-1肾上腺素能受体拮抗剂哌唑嗪(3 mg/kg)预处理不能影响氟哌啶醇诱导的强直性木僵和Fos-IR细胞表达。

The benzylpiperidine derivatives show high activity of inhbiting against AChE in vitro, some of them are even more potent than -Hup A and Tacrine.

苄基哌啶类衍生物的胆碱酯酶活性发现，其与四氢吖啶的衍生物对AChE的抑制活性超过石杉碱甲和Tacrine。

Starting from chiral proline, pipecolinic acid, piperazine-2-carboxylic acid and 1,2-diphenyl amino alcohol, a series of structurally simple and easily prepared amides were developed as highly effective Lewis basic organocatalysts for the asymmetric reduction of imines with trichlorosilane as the reducing agent, which promoted the reduction of N-aryl imines with high yields and excellent enantioselectivities with an unprecedented substrate spectrum.

本文分别由手性脯氨酸、哌啶酸、哌嗪酸以及氨基醇出发，设计和合成了一系列结构新颖、合成简便、性能优良的酰胺类有机小分子路易斯碱催化剂，以廉价的三氯氢硅为氢源，用这些催化剂催化亚胺不对称还原，得到了非常优良的收率、对映选择性和前所未有的底物普适性。

Syntheses of Grignard precursor, N - tert -butyl-4-chloro-piperidine, were accomplished via transamination with a quaternary ammonium piperidone or via addition of methylmagnesium chloride to an iminium ion.

氏体合成， N-叔丁基-4-氯哌啶、出自同一个经转氨酶哌季铵盐或透过增设methylmagnesium亚胺离子的氯化物。

The results showed that the addition leading to -2-phenyl-2-(2-vinylpiperidin-1-yl) ethanol 7 could proceed with good diastereoselectivity and excellent yield (95%).(3) The selective N-deprotection of -2-phenyl-2-(2-vinylpiperidin-1-yl) ethanol 2 without affecting the vinyl group in the substrate were untaken.(4) The Zip reaction for the transformation of -1-(3-aminopropyl)-3-methylazecan-2-one 8 to -7-Methyl-1, Sdiaza-cyclotetradecan-6-one 9 were undertaken. The results showed that, under controlled conditions, acceptable yields (43%) could be achieved and racemization can be minimized during the ring expansion reaction.

该合成路线与文献方法相比，反应条件较温和，也缩短了反应时间；(2)哌啶衍生物2与乙烯基格氏试剂进行加成反应的条件和立体选择性，取得了较好的结果（差向异构体比为80：20，产率95％左右）；(3)不饱和哌啶衍生物7在不影响碳碳双键的情况下去除苯基甘氨醇手性辅助基的条件；(4)具有羰基α位手性的氨基酰胺8在不同条件下经Zip重排反应转变为9的反应，控制反应条件，可使反应中消旋化减小到最小的程度。

The pain response of the most pain units to peripheral noxious stimulation was affected apparently by phentolamine, haloperidol, atropine, diazepam, cyproheptadine.

除对照组外，大多数痛单位对伤害性刺激的痛反应均明显受受体拮抗剂或激动剂如酚妥拉明、氟哌啶醇、阿托品、地西泮、赛庚啶等的影响。

Results: Both drugs had similar efficacy, but clonazepam had less side effects and took into effect quickly.

结果：氯硝西泮与氟哌啶醇肌注疗效相当，而氯硝西泮起效快，副反应较氟哌啶醇轻。

A careful monitoring of potassium levels is needed when using haloperidol because it might exacerbate APD prolongation induced hypokalemia and increases the risk of Torsades de points induced by QT interval excess prolongation.

在使用氟哌啶醇时应密切监测患者血钾浓度，氟哌啶醇可能加重低血钾时APD延长的程度，增加QT间期过度延长诱发Tdp的风险。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。