查询词典 xenograft

Objective To investigate bio characteristics of bone stromal cells in different concentrations of alginate combined with xenograft.

目的 探讨不同浓度的海藻酸盐凝胶与去抗原异种骨构建组织工程载体的生物学性能。

But the role of allograft and xenograft as carriers of rhBMP-2 in spine arthrodesis wasn't reported and reserved exploring

但是同种冷冻干燥异体骨和异种冷冻干燥骨做为rhBMP-2的载体在脊柱后外侧融合方面的作用鲜有人报道，值得探索。

bone marrow mononuclear cells composite bone xenograft can restore caput femoris necrosis, and nearly have the same effects as bone marrow stromal cells.

骨髓单个核细胞确有修复坏死股骨头的效果，且与骨髓基质干细胞修复效果相似。

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

Results: At five weeks, the radiographically and manually determined fusion rate for autologous bone graft was 50％(4/8animals), compared with 100％ and 50％(8/8 and 4/8 anilmals) for groups in which fusions were done by using allograft and xenograft augumented with rhBMP-2. Xenograft+HA used in posterolateral intertransverse arthrodesis yielded a fusion rate of 0％(0/8 animals).

结果：手动试验示：1、自体髂骨组即对照组融合率为50％：2、各实验组融合率分别为：同种冷冻干燥异体骨+rhBMP-2组为100％；异种冷冻干燥骨+rhBMP-2组为50％；异种冷冻干燥骨+HA组为0％。X软片示：1、自体髂骨组即对照组X线评分均值为2.75分，融合率为62.5％；2、各实验组结果分别为：同种冷冻干燥异体骨+rhBMP-2组X线评分均值为4分，融合率为100％：异种冷冻干燥骨+rhBMP-2组X线评分均值为2.62分，融合率为62.5％。

Posterolateral Lumbar Intertransverse Process Spinal Arthrodesis With Composites Composed Of Recombinant Human Bone Morphogenetic Protein 2 And Allograft Or Xenograft; Or With Composite Consisted Of HA And Xenograft in rabbitsBackground: So far spine arthrodesis remains to be used in spine surgery.

中文题名rhBMP-2、HA及其复合物在兔腰椎后外侧融合的实验研究副题名外文题名论文作者杨发军导师马忠泰教授学科专业外科学研究领域\研究方向临床技能训练与研究学位级别博士学位授予单位北京大学学位授予日期2001 论文页码总数92页关键词骨形态发生蛋白异体骨移植脊柱融合异种骨移植馆藏号BSLW /2001 /R687 /42 背景：目前，脊柱融合手术被广泛地应用于脊柱外科领域，自体髂骨仍是被最常用的骨移植物，但是其有5％-35％的不融合率。

Finally,Tumorigenecity of KB-Neo,KB-PF4 and KBp17-70 cells wasassayed with xenograft tumor growth in isogenous nude mice by examiningthe growth speed of xenograft,survival span,and histochemistry ofxenograft nude mice.

最后，对重组的PF4和p17-70基因进行体内实验，建立裸鼠移植瘤模型，观察移植瘤的生长速度、移植瘤的体积、荷瘤鼠的生存时间、移植瘤瘤体组织中的血管密度。

Objective To establish a simple pig-to-monkey xenograft model to study delayed xenograft rejection.

目的 建立一个简便的研究延迟性排斥反应的猪—猴异种心脏移植模型。

The aim of the research is to discover novel genes that are associated with xenograft rejection. This will provide better methods to prevent and treat xenograft rejection.

本研究目的是寻找与异种移植排斥反应相关的候选基因，为异种移植排斥反应的预防和治疗提供新的实验依据。

Currently, it is a highly common sense that pig is the suitable donor of organs, but the great phylogenetic distance between pig and man may induce three kinds of rejection, Hyperacute rejection , Delayed Xenograft Rejection and T cell-mediated Rejection .

现在公认的理想器官供体是猪，但猪的器官移植到人体内会发生三个阶段的排斥反应：超急性排斥反应(Hyperacute Reiection，HAR)、延缓性排斥反应(Delayed Xenograft Rejection，DXR)以及T细胞介导的排斥反应(Tcell-mediated Rejection，TMR)。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。