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DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

Quinazolin-4(3H)-ones(1) were conveniently synthesized from anthranilic acids and amidines,which could be chloridized with POCl_3 to obtain 4-chloroquinazolines (2).The reaction of 2 and 1H-pyrazol-3-amine would give two types of products.In the presence of acid or base,the C-N bond would be formed between the 4-position carbon of 2 and the NH_2 of 1H-pyrazol-3-amine.While the C-N bond between the 4-position carbon of 2 and the NH of 1H-pyrazol-3-amine would be formed when Pd catalyst was utilized.

以邻氨基苯甲酸类化合物和脒为原料，可方便地获得喹唑啉-4(3H)-酮类产物(1)，1经POCl_3氯化可到4-氯代喹唑啉化合物(2)。2与3-氨基-1H-吡唑化合物反应可得到两种类型的产物，在酸、碱条件下2的4位碳和3-氨基-1H-吡唑化合物的NH_2发生C-N成键反应；在Pd催化条件下，2的4位碳则和3-氨基-1H-吡唑化合物的环内NH发生C-N成键反应。

The temperature of cold injury was abo ut 0 ℃ to 15℃,While hot injury would appear when temperature got to 36℃.These ind icat ors were varied in different species,and the greatest difference was the temper ature of cold injury.Growth would be poor in summer under full illumination,whi le part shading was beneficial.The best condition was 70 percentage of sh ading for Araceae and 50 percentage of shading for Agavaceae.The need for soil moistu re was strict.Most of species would grow normally in 65 to 85 percentage of soil m o isture.The characters responsed to illumination,temperature and soil moisture w e re consistent with their original ecologic environment.

其最 适生长温度在16-35℃，除酒瓶兰外，低于10℃时均表现生长停滞状态；寒害温度差异很大，天南星科为0-15℃，龙舌兰科为0-10℃，大多数植物在36℃会产生热害；光照对其影响较大，夏季这两科植物在全光照下长势差而在一定荫蔽的条件下有利生长，最佳荫蔽度天南星科为75％，龙舌兰科为50％；这两科植物对土壤中的水分含量要求较高，大多在土壤含水量70％以上才能正常生长，这些光、温、湿的反应特性与其起源地湿热和荫蔽的生态环境相吻合。

If his argument is correct, then in any case where a suspect makes it clear to the police that he has a request to make before he confesses, unless the police refuses his request immediately, it would amount to the polices assenting to the request, and it would necessarily follow that any confession by the suspect would have been made on account of police inducement and not voluntarily. We do not want to say anything further about this.

如他的论调正确，则任何疑犯向警方表明他有所要求后作出招认时，除非警方立刻拒绝该要求，否则警方等同已答应了他的要求，而疑犯的招认亦必然是受警方诱致而不是自愿作出的。

All this, says Miss Browner, would complement Mr Obama's broader ambition to tackle global warming through a cap-and-trade scheme, whereby the government would set steadily declining annual limits on emissions, and would then auction permits to pollute up to that level.

Browner表示，所有的这些行动都有助于奥巴马实现其雄心壮志，即通过限额交易体系解决全球变暖的问题。由此，政府会要求限额污染排放量逐年下降，并对达到这一水平的污染拍卖许可证。

A true gentleman would have the kind heart when he have companionate heart. He would have the caritative heart when he has the sagacity. He would have the sober heart when he treasure self-pride.

一位真正的绅士有了爱心就有了温存，有了自尊就有了节制，有了睿智就有了胸怀，有了上进心就有了豪情，有了你就有了一生的渴望。

For cheir kind assistance I gradually collected materials and finisfed my work wnder their precions saggestions .Without them ,I would never have reached so far ; without them, the paper would never have been what it is;without them , the ending would not have been so satisfactory.

对于cheir实物援助我逐渐收集材料和finisfed我的工作wnder他们precions saggestions没有他们。，我永远也不会达到迄今为止，没有他们，文件将永远不会被啥它是在没有他们；，截至不会这么理想。

Being collinear would look like, how would you write the routine to be robust, when would

目前共线会是什么样子，你会如何写例程必须是强大的，什么时候

Then I would prefer to have it at your home, that would be cozier and I would have the chance to really talk to people.

那我希望在你家办，因为那样比较温馨而且我比较有机会和大家聊天。

Contrast experiments showed that the "water type trajectory" would be obtained with the promoter of water structure, and "pyridine type trajectory" would be obtained with damager of water structure. They would be related to the strength of electromagnetic field radiation in natural surroundings.

对比 实验表明产生这两类导电轨迹的原因是由于物质对水的结构有促进能力和破坏能力两种不同功能所造成；而电导率持续变化的原因则可能与自然环境某些电磁辐射场强度的持续变化有关连。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新