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Methods: Fresh saphena rings were sudied in organ chamber after incubating with Krebs-Henseleit bicarbonate solutions, FWM, KH with 0.1mmol/L NCR, FWM with 0.1mmol/L NCR at 37℃ for 1 hour. Precontraction induced by prostaglandin F2 (U4661930nmol/L) and endothelium-dependent relaxation induced by calcium ionophore A23187 l0^(-10~l0^(-6) mol/L were measured in the presence of indomethacin (7μmol/L) and LNNA (300μmol/L). Result: No significant changes were found in the 4 groups under the light microscope.

采用器官槽法研究在37℃有氧条件下用重碳酸盐缓冲液、含0.1mmol/L NCR的KH液、FWM液、含0.1mmol/L NCR的FWM液中浸泡血管环1h后，再用7μmol/L吲哚美辛和300 μmol/L N-硝基－L-精氨酸作用后，检测30 nmol/L U46619及不同浓度A23187引发的血管收缩舒张反应。

The method involves an iterative procedure, which incrementally flattens a 3D triangular mesh by region growing and obtains a parameterization with free boundary. The result is then converted to a parameterization with regular boundary by conformal mapping. Our method accounts for both the angle and area distortion during parameterization, it yields a parameterization with less global distortion and no triangular flipping.

采用区域增长算法逐层展平空间三角网格，得到空间三角网格曲面的自由边界的参数化结果，并利用保形变换将自由边界的参数化结果变换为规则边界的参数化结果；同时兼顾了参数化的角度变形和面积变形，使得参数化结果具有整体变形较小的特点，并能够避免三角形折叠的现象。

The MRI signs of brain radiation injury include: definite history of brain radiation therapy, neurologic symptoms emerged after certain period of treatment, the location of lesion coincided with the radiation field, mainly located in white matter, with edema and mass effect, consistent with the MRS result, no dyscrasia.

放射性脑损伤MRI特点：有明确放疗史，神经系统症状於放疗后一定时期出现，定位与放射野吻合，多位於白质；无恶液质表现；有水肿及占位效应，MRS分析结果符合。

Small intestinal biopsies showed subepithelial collagen deposition with varying degrees of villous atrophy and varying numbers of intraepithelial lymphocytes. Four patients had previous biopsies showing enteropathic changes without collagen deposition. Seven cases were associated with collagenous colitis and 1 also had features of lymphocytic colitis. Three patients also had collagen deposition in gastric biopsies. One case was associated with lymphocytic gastritis. Celiac disease (CD, gluten-sensitive enteropathy) was documented in 4 patients. Five patients made a clinical improvement with combinations of a gluten-free diet and immunosuppressive therapy. Two patients died of complications of malnutrition and 1 of another illness. Clonal T-cell populations were identified in 5 of 6 cases tested. Four of these patients improved clinically after treatment but 1 has died. Collagenous sprue evolved on a background of CD in 4 cases. There was no history of CD in others and these cases may be the result of a biologic insult other than gluten sensitivity.

小肠活检表现为上皮下胶原沉积，绒毛萎缩程度不一，上皮内淋巴细胞浸润数量不等。4例患者以往曾做过活检，表现为其他肠病改变，并没有胶原沉积。7例患者合并胶原性结肠炎，且1例还有淋巴细胞性结肠炎的特征。3例患者胃活检也发现有胶原沉积。1例患者合并淋巴细胞性胃炎。4例患者有乳糜泻（CD，谷蛋白敏感性肠病）病史。5例患者经无麸质饮食和免疫抑制治疗后，临床症状有所改善。2例患者因营养不良合并另一种疾病而死亡。6例患者做了T细胞受体基因重排，其中5例发现有克隆性T细胞群，这5例中有4例治疗后临床症状加重，且1例死亡。4例患者在CD的基础上病发胶原性口炎性腹泻；其余患者无CD病史，他们的发病也许是生物源性损害，而非谷蛋白敏感。

The reason is many sided: 1 student and parent think " miscalculate " irrespective, as long as next time attentive dot went. The student allows to use a calculator in 2 education, the student had to the calculator depend on, often abandon when encountering seemingly complex calculation think, use a calculator directly, for instance 618, do not know to change brief into 13, achieve a result with the calculator directly however 0.33. Phase of 3 high school trains a student " put forward, analysis and the ability that solve a problem " the demand is higher and higher, of the train of thought that inscribes to solution in classroom education, thoughtway many somes more tuitional, and to operation ability, because the student has certain base, loosened with respect to some then. 4 emphasizes the training of all sorts of thinking ability overly, the training of operation ability has the suspicion that should try education it seems that, this also is one of reasons. The operation in 5 maths, no matter be numeric computation, return be algebraic type to be out of shape figure, photograph of the train of thought that inscribes with new knowledge, new solution, skill is compared and character, appear more as dry as a chip, the student does not have interest.

原因是多方面的：1学生和家长都认为"算错了"没关系，只要下次细心点就行了。2教学中答应学生使用计算器，学生对计算器有了依靠，在碰到貌似复杂的计算时往往舍弃思索，直接用计算器，比如618，不知化简成13，而是直接用计算器获得结果0.33.3高中阶段培养学生"提出、分析和解决新问题的能力"的要求越来越高，课堂教学中对解题的思路、思想方法的讲授多一些，而对于运算能力，因为学生都有一定的基础，于是就有些放松了。4过分强调各种思维能力的练习，运算能力的练习似乎有应试教育的嫌疑，这也是原因之一。5数学中的运算，不管是数值计算，还是代数式的变形演算，和新的知识、新的解题的思路、技巧相比较而言，显得比较枯燥，学生没有喜好。

Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.

在实验研究基础上，本研究进一步运用免疫沉淀和Western Blot印迹方法，检测AML患者原代细胞JAK2和STAT3活化情况，并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现，11例AML患者中，有3例呈现STAT3组成型活化（STAT3阳性，下同），无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性；在此3例患者中，1例未取得缓解，另外2例虽然取得短暂缓解，但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高，而凋亡率数值较低。

objective: the clinical date of 60 cases of early syphilis were analyzed.and summed up with the morbid condition ,types of tetter and therapeutic effect.method:all patients were divided into four groups and offered benzathine benzylpenicillin,ceftriaxone, tetracycline and azithromycin respectively.result: the cure risks of the groups treated with benzathine benzylpenicillin or ceftriaxone were all 100 percent, and no repellency in serum of the patients treated with ceftriaxone, the cure risks of the groups treated with tetracycline or azithromycin were all 80 percent.conclusion : it is indicated that benzathine benzylpenicillin and ceftriaxone were all of the best effective drugs.

目的：对60例早期梅毒患者发病情况、皮疹类型、治疗效果进行临床分析和总结。方法：分别采用苄星青霉素、头孢曲松、四环素及阿奇霉素治疗。结果：苄星青霉素、头孢曲松组，临床治愈100%，头孢曲松组无血清学抵抗，四环素、阿奇霉素临床治愈80%。

the lcd display character is acquisited by ccd,after analysis with image process and artificial neural network theory,through grid and intersecting lines to pick up the character′s characteristic,recognize lcd display character,provide with a kind of interface for the instruments and equipments which have no standard interface with the computer but have a lcd display.the experiment result shows that the system acquire and recognize lcd display character is very successfully,and high anti-jamming ability.

摘 要：利用ccd对lcd数码显示字符进行采集，在分析图像处理和神经网络理论的基础上，采用网格法与交线特征提取法，对lcd数显字符进行识别，为具有lcd数显而与计算机无标准通信接口的仪器仪表设备提供一种实用的无线接口。实验表明，系统对lcd数显字符采集方便，识别率高，并且抗干扰能力强。中图分类号：tm932；tp216 文献标识码：b

The transition from the systemic inflammatory response syndrome to seere sepsis and septic shock inoles a myriad of pathogenic changes, including circulatory abnormalities that result in global tissue hypoxia.1,2 These pathogenic changes hae been the therapeutic target of preious outcome studies.12 Although this transition occurs oer time, both out of the hospital and in the hospital, in outcome studies interentions hae usually been initiated after admission to the intensie care unit.12 In studies of goal-directed hemodynamic optimization, in particular, there was no benefit in terms of outcome with respect to normal and supranormal hemodynamic end points, as well as those guided by mixed enous oxygen saturation.9,13 In contrast, een though we enrolled patients with lower central enous oxygen saturation and lower central enous pressure than those studied by Gattinoni et al.9 and with a higher lactate concentration than those studied by Hayes et al.,13 we found significant benefits with respect to outcome when goal-directed therapy was applied at an earlier stage of disease.

从全身炎症反应综合征转为严重脓毒症和脓毒性休克牵涉大量发病的变化，包括导致全身性缺氧的循环紊乱。这些发病的变化成为先前结果研究的治疗学目标。尽管这些转变随着时间的流失而逐渐出现，既可以在院外，也可在院内，在结果研究中，干预措施往往在进入ICU之后才启动。特别的，在那些目标导向血流动力学最优化研究中，依照结果，那些以正常或超正常血流动力学为终点的措施未能显示出益处，以混合静脉血氧饱和度为导向的研究同样如此。

The program of AER+RES was similar to AER, but went through resistance exercise 20min in base section of every exercise trail.Result: Prior to intervention, adiponectin levels were significantly correlated with BMI、 WHR、 COS、 LN、 LN、 TG、 LG10、 LN、 weight、 waist、 FM、%F, and leptin levels were significantly correlated with BMI、 WHR 、 LN 、 LN 、 TG 、 HDL-C 、 LG10、 apoB 、 apoA1/apoB、 waist、 F1M、%F. Stepwise multiple regression analysis revealed that LG10; COS and waist was an predictor of basal adiponectin levels , and %F,apoB and WHR was an predictor of basal leptin levels. In early obesity, adiponectin and leptin can be worsened , along with the changed of body component, fasting plasm glucose and lipid accumulation. After intervention, both group were significantly reduction in FM,%F,weight, WHR,FPG and TG, while HDL-C had significantly increased.AER exhibited significant in leptin, while AER+RES did not show the change. Insulin and HOMA-IR were changed in both groups. The control group exhibited no significant change in any variables. Although adiponectin levels were unchanged in the three groups, a significant negativecorrelation between delta %F, delta WHR and delta FPG was observed. Futhermore, if compare the degree of delta weight, we fought a significant increased in adiponectin between the group of delta weight higher (=3kg) than delta weight lower(=0kg), delta %F, delta WHR and delta weight were significant negative correlation with delta leptin.

结果：绝经妇女脂联素水平与体重指数、腰臀比、空腹血糖、空腹胰岛素、LEP、TG、极低密度脂蛋白胆固醇、胰岛素抵抗指数、体重、腰围、体脂含量、体脂百分比显著相关；瘦素水平与BMI、WHR、FINS、LEP、TG、HDL-C、VLDL-C、载脂蛋白B、apoA1／apoB、腰围、FM、％F等指标显著相关；多元逐步回归分析显示LG10、COS和腰围是基线脂联素水平的预测变量，而％F，apoB和WHR是基线瘦素水平的预测变量；在肥胖前期，脂联素、瘦素已经出现明显不良变化，同时也伴随着体成分、空腹血糖和血脂的异常；运动实验后，两个运动组的FM、％F、体重、WHR、FPG、TG都显著下降，而HDL-C显著上升；AER组瘦素显著下降，而AER+RES组则没有显著变化；两组的胰岛素和HOMA-IR水平都有显著下降；对照组所有指标都没有明显变化；尽管运动后脂联素水平没有显著变化，但是脂联素变化量与％F、WHR和血糖变化量显著负相关，而且如果按照运动后体重下降的程度比较，则体重下降大(≥3kg)的受试者比下降小的(≤0kg)脂联素水平有明显升高；运动后瘦素水平的变化量与％F，WHR及体重的变化量显著负相关。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失