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The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

It being in spring and the small birds they were singing Down by a shady arbour I carelessly did stray Where the thrushes they were warbling The violets they were charming For to view two lovers talking a while I did delay She said,"My dear, don't leave me all for another season Though fortune may be pleasing I'll go along with you I'll give up friends and relations and quit this Irish nation And to the bonnie Bann banks forever I'll bid adieu" He said, My dear, don't grieve me or yet annoy my patience You know I love you dearly although I'm going away I'm going to some foreign nation to purchase a plantation For to comfort us hereafter all in America. The landlords and their agents, their bailiffs and their beagles The land of our forefathers we're forced for to give o'er And we're sailing on the ocean for honor and promotion And we're parting with our sweethearts, it's them we do adore If you were in your bed lying and thinking of dying One sight of the bonny Bann banks, your sorrows you'd give o'er And if your were but one hour all in her shady bower Pleasure would surround you, You'd think on death no more So fare thee well, sweet Craigie Hill, where ofttimes I have roved in I never thought in my childhood days I'd part you any more But we're sailing on the ocean for honour and promotion And the bonny boat's sailing way down by Doorin shore

那是在春天的时节，小鸟儿们在歌唱沿着远处婆娑的海港，我不经意间竟迷失了方向画眉鸟柔和的唱着歌，还有那娇媚的紫罗兰竞相开放看着多情的恋人们低语，我停下了脚步她说，亲爱的请不要在任何季节离我而去虽然命运将我们捉弄，我还要与你在一起我会放弃亲友放弃爱尔兰民族的祝愿我对神发誓，我永远都不会说再见他说，亲爱的请不要悲伤，否则会困扰我的耐心你要知道即使离开，我只会更强烈地爱你我要去一个遥远的国度，去寻觅一片土地来抚平灾难给我们带来的所有创伤不久以后当一切都已经平息我将让所有人都因我们这次离别而幸福我们将像维多利亚女皇一样快乐，有着她最伟大的荣耀我们要在这废墟上品尝美酒佳肴如果你躺在床上正思考着死亡爱之神的目光，将你的忧伤带到我身旁或许瞬间就会降临，降临在那幽暗的凉亭快乐将围绕着你，你将不会再想到死亡所以永别了吧，我可爱的克雷吉山峦，我曾漫游数次的地方我以为从我孩童时期起就不会再和你分开而如今我们却航行在荣誉和重生的海洋里沿着多里安海岸，美丽的船儿在航行

Craigie Hill 演唱:Cara Dillon It being in spring and the small birds they were singing Down by a shady arbour I carelessly did stray Where the thrushes they were warbling The violets they were charming For to view two lovers talking a while I did delay She said,"My dear, don't leave me all for another season Though fortune may be pleasing I'll go along with you I'll give up friends and relations and quit this Irish nation And to the bonnie Bann banks forever I'll bid adieu" He said, My dear, don't grieve me or yet annoy my patience You know I love you dearly although I'm going away I'm going to some foreign nation to purchase a plantation For to comfort us hereafter all in America. The landlords and their agents, their bailiffs and their beagles The land of our forefathers we're forced for to give o'er And we're sailing on the ocean for honor and promotion And we're parting with our sweethearts, it's them we do adore If you were in your bed lying and thinking of dying One sight of the bonny Bann banks, your sorrows you'd give o'er And if your were but one hour all in her shady bower Pleasure would surround you, You'd think on death no more So fare thee well, sweet Craigie Hill, where ofttimes I have roved in I never thought in my childhood days I'd part you any more But we're sailing on the ocean for honour and promotion And the bonny boat's sailing way down by Doorin shore

那是在春天的时节，小鸟儿们在歌唱沿着远处婆娑的海港，我不经意间竟迷失了方向画眉鸟柔和的唱着歌，还有那娇媚的紫罗兰竞相开放看着多情的恋人们低语，我停下了脚步她说，亲爱的请不要在任何季节离我而去虽然命运将我们捉弄，我还要与你在一起我会放弃亲友放弃爱尔兰民族的祝愿我对神发誓，我永远都不会说再见他说，亲爱的请不要悲伤，否则会困扰我的耐心你要知道即使离开，我只会更强烈地爱你我要去一个遥远的国度，去寻觅一片土地来抚平灾难给我们带来的所有创伤不久以后当一切都已经平息我将让所有人都因我们这次离别而幸福我们将像维多利亚女皇一样快乐，有着她最伟大的荣耀我们要在这废墟上品尝美酒佳肴如果你躺在床上正思考着死亡爱之神的目光，将你的忧伤带到我身旁或许瞬间就会降临，降临在那幽暗的凉亭快乐将围绕着你，你将不会再想到死亡所以永别了吧，我可爱的克雷吉山峦，我曾漫游数次的地方我以为从我孩童时期起就不会再和你分开而如今我们却航行在荣誉和重生的海洋里沿着多里安海岸，美丽的船儿在航行

In this paper, the concept of network security and security structures of OSI and Internet is introduced, and various threats confronting the computer network are also discussed. Several kinds of network information security technologies, including firewall technology, virtual private network, intrusion detection system, data encryption technology, identity authentication and security protocol etc. are also examined. The security of internal network is the biggest problem in the construction of each network. The solution to this problem lies in setting up a firewall. The theory of a firewall and the approach to its actualization is studied. Intrusion detection system, an important part of the computer network security system, has gained extensive attention. IDS monitors the computer and network traffic for intrusion and suspicious activities. It not only detects the intrusion from the extranet hacker, but also the intranet users. The emergence of virtual private network paves the way for realizing secure connection of LAN quickly and at a relatively low cost. The concept, function, key techniques, including the tunnel technology, and the ways to realize VPN are expounded in this paper. Also introduced is the data encrypt network technology, which is called the soul of computer network security, such as digital digest, digital signature, digital certificate, digital encrypt arithmetic and so on. At the same time, the principle and the process of implementing network security by digital certificate and digital signature, the basic principle and characters of security protocols, and finally, three of the security protocols, concerning the security problems in network, IPsec, SLL and SET are analyzed in detail Computer network system should be a system of dynamic defence, both dynamic and static, passive as well as active, and even offensive, combined with management and technology.

本文系统地介绍了网络安全的概念、OSI及Internet的安全体系结构，并讨论了计算机网络面临的各种安全威胁；内部网络的安全问题是每个建网单位面临的最大问题，可以认为防火墙技术是解决网络安全的一个主要手段，本文研究了防火墙的原理及其实现手段；作为一种主动的防御措施，入侵检测系统作为网络系统安全的重要组成部分，得到了广泛的重视，TDS对计算机和网络资源上的恶意使用行为进行识别和响应，不仅检测来自外部的入侵行为，也监督内部用户的未授权活动；虚拟专用网技术的出现，为实现网络间的连接提供了快速安全但又相对便宜的手段，本文较深入的探讨了实现VPN的隧道技术，并对VPN的概念、功能、实现途径、基本构成、关键技术及发展前景等问题进行了全面论述；数据加密技术是网络安全核心技术之一，本文从数据加密算法、数字摘要、数字签名及数字证书等几方面简要介绍了数据加密技术，并分析用数字证书和数字签名实现网络安全的原理和过程；对安全协议的基本原理、主要特点进行了较为深入的研究，并就网络的安全性问题剖析了三种安全协议：IPsec协议、SLL协议和SET协议。

My name is XX,24 years old,Koreaner,and graduated from XX major on july this year.i have dad ,mom,and sister in my family.father is a worker in a airport,while mother is a teacher.i grew up at such traditional family,so parents were strict with me,they tought me much.until graduation from high school,I was able to enterYanbian University without parents' care.instead of feeling reluctant to part with parents,I was imvolved in new life rapidly.because of my lively personality and easy-going,teachers and classmates spoke highly of me.at other times,I loved reading and searching information in the internet.morover,I reinforced own Korean,english and computer competency continuously,took advantage of two years to study korean in the opportunity class,and then met many foreign friends to proceed mutual learning as partners.over my four-studing out of home,I cultivated strong characteristic,which made me overcome many difficulties from studying nad living.i majored in education technology ,the professional subjects contain three aspects about hardware and software on computer,education and use of multimedia,for example,OFFICE software,IMAGE-PROCE ING software,NLE software and various computer language,data organization,digit circuit,education,educational psychology,distance learning etc.i valuing practice often do come part-time jobs to accumulate some social practice experiences by making use of outside school hours ,except for the basic curriculums in the school.in my leasure time,I often go sporting,such as mountaineering,swimming,riding bicycle and so on,as well as paricipation some activities organized by sc

我叫XX，今年24岁，朝鲜族，今年7月毕业于XX专业。家庭成员有爸爸、妈妈和姐姐，父亲是一名飞机厂工人，母亲是一名人民教师，从小在这样传统的家庭中成长，父母对我的管教也很严格，教会了我许多做人的道理。直到高中毕业，离开父母呵护的臂膀来到了延边大学，没有对家的恋恋不舍，而是很快的融入到了新的生活中，由于我的性格活泼开朗并且随和，老师和同学们对我的评价也都非常好，平时我喜欢看书和上网浏览信息，另外不断加强自身的韩国语、英语和计算机能力，利用两年时间在补习班学习了韩国语，并认识了许多外国朋友结成partner互补学习，在外求学的四年中，我养成了坚强的性格，使我克服了许多学习上和生活中的一些困难。我的专业是教育技术学，专业课程包括计算机的硬件及软件、教育学和多媒体的使用三大方面。OFFICE软件、图象处理软件、非编软件以及各种计算机语言数据结构，数字电路，教育学、教育心理学、远程教育等。注重实践的我除了学校的基本课程外，经常利用课余时间做一些兼职以积累一定的社会实践经验，平时还喜欢做一些运动，例如登山、游泳、骑自行车等，并经常参加学校里组织的一些活动。开朗乐观是我对待生活的态度，吃苦耐劳是我对待工作的原则。

Lasting Chanel, Chanel has already become the most well-known brand of world;Double the classic LOGO of the C will inherit a vogue forever popular, never be absent.The Chanel madam is born in 1883 and passes away in 1971, the COCO is her childhood name, although she lees us for a long time, the style of its classic always that time still the founder of boundary.She most shows affection for to be with black and white carry on beautifully changing magically and carry out a kind of absolute pleasant impression and perfect harmony.She lee many become the direct mind tutor who guides to spread this ages to popular viewpoints, she think what the United States point is inside outside all beautiful, although spread to continuously put forth new ideas, the style can never be eliminate.In the meantime her believe deeply is the be"simple" st way which lets the fine texture present and her classic design for lee include:NO.5 perfume, be the inclined line soft, double color shoe, black and small dress etc., the accessories of classic is the leather that the assertion lets woman's hands vacate to wear the handbag that the chain take, she show affection for of the mountain camellia also still blooms in the dinner of silk ans stain the pack the ectype pattern.Chanel although from clothing house, as early as 1925 she starts entrust to produce a little amount rouge, lipstick and skin care products and provide oneself and the guest use, display just in the Chanel dress boutique, these merchandises he already beat up the CHANEL name, the perfume of the No.5 appears on market in 1921, beginning go toward perfume, cosmetics development, perfume and cosmetics he become Chanel performance very outstanding item now, separate to release a kind of new perfume for a while each time, in the aspects of leading cosmetics fad, Chanel also takes a lot of trouble, the quarterly releases a new merchandise each time, and lead the quarter don't sell!

永远的香奈儿，香奈儿已经成为全球最知名的品牌；双C的经典LOGO将永远袭卷时尚流行、永不缺席香奈儿夫人出生于1883年、逝世于1971年，COCO是她的小名，虽然她离开我们很久，但是其经典的风格一直是时尚界的鼻祖她最钟爱用黑色与白色进行美丽的幻化，实现一种绝对的美感以及完美的和谐她留下许多对流行的看法，成为引导这个时代流行的直接心灵导师，她认为美指的是内外皆美，虽然流行不断推陈出新，但是风格永远不会被淘汰香奈儿虽然由服装起家，但早在1925年她就开始委托生产少量腮红、口红和保养品，供自己和客人使用，仅在香奈儿服饰精品店陈列，但这些商品已打上CHANEL名号，1921年五号香水上市，开始往香水、化妆品开发，现在香水与化妆品已成为香奈儿表现相当出色的项目，每隔一阵子就推出一种新香水，在领导化妆品流行方面，香奈儿也煞费苦心，每一季推出一项新商品，而且过季不售！

The following points are emphasized:The operation models of adiabatic and diabatic distillation have been set up and the operation block, thermodynamics model and mathematical model in the simulation have been determined as well;(2)Based on the simulation and exergy analysis with Aspen Plus program, shortcut distillation design—DSTWU model and rigorous distillation design—RADFRAC model, the author has determined the heat duty, exergy losses and the distribution of exergy losses along the adiabatic column, which will help the simulation and optimization of the diabatic distillation;(3)Diabatic distillation under various operation conditions has been simulated by using energy balance method and exergy analysis;(4)How the different mixture and the various degree of separation, number of trays and feed location influence exergy saving in diabatic distillation have also been discussed;(5)On the basis of the total exergy losses along the column, different schema of the heat transfer distribution along the column have been compared and analyzed;they can be classified in three categories: heat duty equipartition approach, empirical approach, separation degree matching approach. In conclusion, different heat transfer distribution along the column will have effect on total exergy losses. In particular, most satisfactory results have been obtained by using separation degree matching approach. In order to diminish the exergy losses, heat transfer distribution should meet the needs of the request of separation degree.And on this premise, the author makes his suggestion in increasing the proportion of heat supplied to the tray with minimum exergy losses and decreasing the proportion of heat supplied to the tray with the maximum exergy losses.

本文对透热精馏过程进行了模拟并对其节能效果的影响因素做了较为全面的分析和深入的研究，主要研究内容如下：(1)建立了常规精馏和透热精馏过程的模拟操作模块、热力学模型以及数学模型；(2)利用化工模拟软件Aspen Plus并分别采用DSTWU简捷模型和RADFRAC严格计算模型对常规精馏进行模拟计算和有效能分析，确定常规精馏塔的公用工程热负荷、有效能损失及有效能损失在塔内的分布，为透热精馏的模拟和优化提供数据参考；(3)对不同物系在不同分离度条件下进行透热精馏的模拟，分别采用能量衡算法和有效能分析法进行计算和分析；(4)探讨了各种因素如物系的选择、不同分离度、塔板数、进料位置对透热精馏节能效果的影响；(5)以全塔总有效能损失为比较基准，对热量在塔内的三种分布方案即热负荷平均分配法、经验法和分离度匹配法进行了对比分析并得出结论：塔内热量的不同分布方案对于全塔总有效能损失会产生影响，其中以分离度匹配法的节能效果最为理想，为减少有效能的损失，应使塔内的热量分布满足各塔板的分离度要求，并在此前提下，尽量减小有效能损失大的塔板的热负荷和增加有效能损失小的塔板的热负荷。

The biomechanical tests showed that two kinds of artificial bones had not significant difference on compressive strength and Young\'s modulus(P＞0.05),while the flexural strength of nano-nacre artificial bone was less than the control group(P＜0.05).3.The results of CCK-8 showed that the difference were not significant in each group,the proliferation of osteoblast reached the peak at the 5th day;7 days after being co-cultured,the total protein content of study group was higher than control group and blank group(P＜0.05),while the difference between control group and blank group was not significantP＞0.05The difference of alkaline phosphatase activities among three groups was not significant(P＞0.05The SEM view showed that osteoblast attached and grew well in two kinds of artificial bone.4.X-ray photography showed that two kinds of powder started to degrade in 2 weeks;this phenomenon became more appear in 4 weeks,nano-nacre powder degraded faster than micron-nacre powder,while the hole shadow was easy to be found;in 8 weeks,all the femoral holes recovered and returned to normal bone mineral density in all groups.Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone grew fastest around the bone defect area in study group,while most slowly in blank groupP＜0.05 SEM(scanning electron microscope observation showed that nano-nacre powder degraded more quickly.The same result can be found through the demineralized sections morphometric analysis,and both of the composite artificial bones made from those two kinds of nacre powder had the good connection with the adjacent tissue in rats body without apparent inflammatory response.5.X-ray photography showed that rabbit\'s bone defects healed faster in study group since NNAB implanted than in control group since MNAB implanted.At 24 weeks after operation,bone density in radial defects had nearly accessed to the normal area,while lower in control group,and turned up nonunion in blank group;The checking of BMD showed that results in study group were higher than those in control group at 8,16 and 24 week(P＜0.05), and the difference between the BMD values in study group at 24 week and those in blank group was not significant(P＞0.05).The gross specimens showed satisfactory histocompatibility both in study group and in control group,with bone tissue growing from two sides into the center of implanted materials; Normal slices in HE stain and hard tissue grinding slices in Stevenel\'s blue/Van Geison\'s picro-fuchsin stain showed that the bone growth tendency was better in study group than that in control group,and the medullary cavity had been penetrated to the implanted materials in study group at 24 week;Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone in both groups grew fastest 8 weeks after surgery,while slow down at 16 week.

纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨分别与成骨细胞共培养后，其各时间点CCK-8法检测值与空白对照无显著差异(P＞0.05)，成骨细胞均在第5天达到增殖高峰期；培养7天后，实验组细胞蛋白含量高于对照组及空白组(P＜0.05)，后两者之间则无显著差异P＞0.05碱性磷酸酶活性在三组间均无显著差异(P＞0.05电镜下可见成骨细胞在两种人工骨上都有良好生长贴附能力。4.X-ray显示两种粉体在大鼠股骨骨洞植入第2周时都开始出现了降解，第4周时更为明显，纳米珍珠层粉较之微米珍珠层粉降解更快，而空白对照组骨洞阴影仍可见，至8周时，则所有组骨洞均己闭合修复，X-ray下已不可见原钻孔痕迹，恢复正常骨质密度；硬组织磨片四环素荧光双标记结果显示纳米珍珠层粉植入组较其余两组在骨缺损区周围新骨生长速度更快，空白组速度最慢P＜0.05电镜观察及常规脱钙切片亦可见到纳米粉体降解较快；由以上两种原材料制得的纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨在大鼠体内均与周围组织结合良好，无明显炎症反应。5.X-ray显示纳米珍珠层/消旋聚乳酸复合人工骨植入兔桡骨缺损区后其骨愈合速度较对照组微米珍珠层/消旋聚乳酸复合人工骨植入的快，至植入术后24周，实验组骨缺损区接近正常骨密度，对照组骨缺损区密度较低，空白组则呈现骨不连状态；骨密度测量结果显示术后8周、16周、24周实验组的骨密度值高于对照组(P＜0.05，24周实验组的骨密度值与术前所测得的正常值无显著性差异P＞0.05动物取材大体所见均显示组织相容性良好，骨组织逐渐由植入材料两端向中央生长；常规切片HE染色及硬组织磨片Stevenel\'s blue/Van Geison\'s picro-fuchsin联合染色均可见实验组骨缺损区长势优于对照组，至术后24周，实验组骨髓腔与材料已呈相交通状；硬组织磨片荧光显微镜下观察，两组材料在术后8周处于骨生长最快速时期，16周时速度开始减慢，术后4、8、16周时实验组的新骨生长速度均较对照组的快

For this expert advice, the State departments and the relevant industry associations to actively guide the major manufacturers of advanced study abroad, as well as the management experience of brewing technology, set up high-quality wine grape production base and increasing the investment base of grape, set up a classification system for quality, and strive to enhance capability of independent innovation, to build strong brands, combined with China's geographical characteristics, etc., developed a number of Chinese characteristics and in line with China's vast number of consumers taste varieties, actively respond to the impact of foreign wine industry.

国家部门和有关行业协会要积极引导出国深造的主要制造商，以及酿造技术管理经验，建立了高品质的酿酒葡萄生产基地和增加投资的基础葡萄，建立了质量分级制度，努力提高自主创新能力，建立强有力的品牌，与中国的地理特征相结合等，制定了中国的一些特征，并与中国的广大消费者的口味线品种，积极应对国外葡萄酒行业的影响。

Humanity has always had a strange avidity for unusual sexual postures, and if a man likes to use his wife, as Benvenuto Cellini says, 'in the Italian way', well that is a matter of taste. But I had hardly expected our game-keeper to be up to so many tricks. No doubt Bertha Coutts herself first put him up to them.

人类一向就是婪无厌地探究着性交的特殊姿式的，假如一位丈无喜欢和他的女人&意大利式&地一如赛凌尼的说法一尽情尽意，又有什么不可呢，那不过是嗜好的问题罢了。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。