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So it is a effective prescription of protecting and treating AD.In our experiments, the model ras were administered D-gal intraperitioneal injection and β-Amyloid protein fragment_(1-40) into hippocampus. Mean well we used the technique of optical lens、 electron microscope、 immunohistochemical method, biochemistry and molecular biology.We studied the mechanisms that DR pretect and treat AD from the aspects of apoptosis、 inflammation injury、 oxidative injury 、 cholinergic neuron injury and the behavior experiments at cellar and molecular level.

本实验复制了D-gal腹腔注射合并Aβ_(1-40)海马定向注射AD动物模型，运用光、电镜技术及免疫组化、生物化学及分子生物学等先进检测方法，从行为学及细胞、分子水平探索地黄饮子对过氧化损伤、胆碱能损害、炎症损伤、细胞凋亡等相关调控因素影响的作用机制。

What We're All About : Nevertheless I'm not dressed for the occasion It's number 32 now here's the situation If the beat moves your feet then don't change the station Pack your bags cause we're leaving on a permanent vacation Well, I'm a disaster A microphone master Put on your tape and rock your ghetto blaster It's not about the money, cars, hotels, or resorts About sweating all the bitches in the biker shorts I'm Dave Brown Sound and you see me running late Cause I'm always making time to make your girlie feel great And I'm Bizzy D from way down town I'm known to rock a mic like a king was a crown When I'm on top I'm gonna borrow that bootie Hustling deals like Mickey Macooty When I wake up I like a pound of bacon Start off the day with my arteries shaking Rock!

够长的。。脑力活都变成体力活了，记得以前看过无数次这首歌的LIVE 我仍然穿得不合场合这里是32号如果你的双脚没有随着节拍跳跃那么请你换个地方打好你的背包因为我们正起程去度过一个永恒的假日好的我是一个灾难是麦克风的主人带上你的磁带摇滚你的犹太人区的爆破工这无关金钱汽车旅馆或者胜地而是关于让所有婊子在摩托车手的短裤里流汗我是Dave Brown Sound 你看我急匆匆的来迟了因为我总是把时间花在让你的妞享受快乐上面我是Bizzy D来自市区我被通知去当主唱就像国王是皇冠一样当我站在最上面我就要把女人的短靴借过来强取这待遇就像Mickey Macooty 当我醒来时我想吃一磅熏肉以动脉的震动来开始这一天摇滚吧！

We thought we'd had her out there too long and she'd gone off the rails.

她在对方公司干了那么长时间，已经不再我们的控制之下了

We want to bring this form of racing online and we will also be starting an online Initial D Drift league where players around the world can challenge each other in the league to become the fastest drift racer in the world.

我们想把该比赛形式搬到网络上，而且我们打算建立一个网上的Initial D漂移联盟，让联盟之内的全世界的玩家可以相互挑战以在比赛中变得更快。

Of course, we'd all like to think we'd handle the bad news more sanely.

当然，我们都愿意认为我们会更加理性地对待坏消息。

We'd do sit ups in the water with out feet on the pool edge, we'd tred water.

我们想要做仰卧在水中进行的水池边脚，我们就tred水的窗口。

In this paper, we studied M. meretrix ferritin, cathepsin B and caspase genes, which are involved in clam larval shell formation, nutrition, metabolism and apoptosis, respectively. We have cloned the three genes, investigated the temporal and spatial expression profile both at gene and protein level in trochophore (L1), D-veliger (L2), pediveliger (L3) and postlarvae (L4). The potential roles of these proteins were analyzed with specific inhibitors during larval development. Firstly, embryos were found developed into trochophore-like larvae with no shell if cultured at gastrula stage in artificial seawater without iron. Shell-like structures were formed only in the presence of iron. The larvae which had been transferred at L1 stage into ASW developed normal shell. This indicated that iron and iron associated protein are important for larval shell formation. The EST sequence which is homologous with ferritin, which is a principal iron metabolic protein, was selected from the M. meretrix cDNA library. The full-length of ferritin subunit cDNA was cloned by RACE. The results of real-time PCR revealed that the MmeFer mRNA expression changed before and after the larval shell formation.

本论文以文蛤幼虫为研究对象，分别对文蛤幼虫发育过程中贝壳形成相关的铁蛋白、营养及变态相关的组织蛋白酶B及变态过程中细胞凋亡相关的caspase三个基因进行了克隆，分析了基因及编码蛋白在担轮幼虫期(L1)、D形幼虫期(L2)、壳顶幼虫期(L3)和稚贝期(L4)的时空表达特征，解析了其可能的功能，并研究了相应酶类的特异性抑制剂作用对幼虫发育过程的影响，进行了目标蛋白的功能验证，详述如下：研究结果显示，在文蛤胚胎发育到原肠胚时放入不含铁离子的人工海水中培养，发育成无壳的畸形，随着人工海水中铁离子添加浓度的升高，幼虫长出壳状组织接近正常状态；而发育到L1期幼虫放入不含铁离子的人工海水中培养却可以发育出正常的壳，推测铁和铁代谢相关蛋白在幼虫贝壳初始形成有重要的作用。

Started from D-tyrosine, we obtained the tetramic acid 96 using Jouin reaction. The assembly of the second fragment 109 was stared from 1,4-butandiol,using asymmetric alkylation reaction developed by Oppolzer as a key step. Coupling of the tetramic acid 96 with 109 provided the key intermediate 110 according to Yoshii\'s procedure. After remove protective group and Sharpless epoxidation, we obtained the key intermediate 113. Its macrocyclization to form the final product is in progress.

本论文的第二章主要对Macrocidin A开展了合成工作，我们从D构型的酪氨酸出发，经过官能团转换；利用Jouin反应生成Tetramic acid 96，另外一个片断从1，4-丁二醇开始经过多步反应生成碘化物104，利用Oppolzer发展的手性樟脑磺酰胺为辅基参与的不对称烷基化反应，引入手性甲基，生成关键中间体109，接着通过Yoshii发展的方法连接96和109生成110，经过Sharpless不对称环氧化反应建立环氧化合物，然后脱去保护基得到关环前体113，分子内的Mitsunobu反应进行关大环反应正在进行之中。

Ve schizophrenic inpatients will be enrolled into the 6-week, randomized, double-blind trial of sarcosine monotherapy (1000~3000 mg/day, N=75) vs. risperidone (2~6 mg/d, N=75). We will measure clinical efficacy and side effects biweekly during the treatment. At the beginning and the end of the trial, we will also measure cognitive function (e.g. intellect, attention, memory, executive function), serum amino acids, expressions of mRNA (by realtime quantitative RT-PCR) and protein of NMDA-related genes (such as SHMT2, AMT, PSAT1, ASCT1, and serine racemase) in peripheral blood lymphocytes.

第一部份将收案150位未曾治疗之精神分裂症住院患者，以双盲方式随机给予六周sarcosine (1000-3000 mg/day，N=75)或risperidone (2-6 mg/day，N=75)治疗，我们将每两周评估临床疗效与安全性，并在研究开始及结束时，评量认知功能(智能、注意力、记忆力、执行功能)并测定血清中glycine或D-serine浓度以及SHMT2、AMT、PSAT1、ASCT1、serine racemase等基因於周边淋巴球之mRNA (以realtime RT-PCR测定)与蛋白质表现量。

John:"Okay, sure. We'd be poor at first, but we'd be happy."

好吧， 我们一开始会穷一些，但我们会很开心。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。