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Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.
结果:酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间,给药剂量为80μg/kg/d时疗效最显著,达到69.24%,在20μg/kg/d-80μg/kg/d剂量范围内生命延长率为50-70%,给药剂量与荷瘤鼠生存时间呈现一定量效关系;酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长,给药剂量为160μg/kg/d时疗效最显著,抑制率为44.03%,并且在40-320μg/kg/d剂量范围内抑制率为25-50%,给药剂量与肿瘤抑制率呈现一定量效关系;酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用,在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显,其中浓度为100μg/ml时抑制率达19.36%;酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤:体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与效应细胞对照组相比有显著性差异(P<0.05)杀伤率分别达到35.58%、61.2%;体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P 。05),杀伤率分别达到21.39%、47.63%;裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P.05),最高杀伤率分别达到32.86%、73.07%;酪丝亮肤能增强单核巨噬细胞系统的吞噬功能,吞噬指数与生理盐水组比较有显著性差异(P.05);酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与效应细胞对照组相比有显著性差异(P.05);酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与生理盐水对照组相比有显著性差异(P.05);酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO,IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰,酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能,而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。
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Results: CK18 was not detected in normal and abnormal oral tissue sections. But in normal nonkeratinized mucosa, CK19 was detected in the basal cell layer dispersively. In epithelial dysplasia, CK19 was detected in the suprabasal cell layer and the number of CK19-positive cell layers was correlated with the dysplasia degree of epithelia. Furthermore, CK19 was detected in oral squamous cell carcinoma, especially in the poor-differentiated cancer cells.
结果:正常和异常的口腔粘膜均未检测到CK18;CK19可表达于正常非角化上皮的基底层细胞、异常增生上皮的基底上层细胞及口腔鳞状细胞癌中,阳性细胞数与上皮的异常增生程度及鳞癌的分化程度相关。
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During the process of the fore mentioned analyses, some tentative works as follows were done.(1)On the basis of the fundamental of spatial analytic geometry, the basic method for displaceable block searching was put forward and the relevant program was written. With this program one can easily search out all the displaceable blocks and omitting of blocks, which is very common in searching blocks manually, can be avoided.(2)The coefficient of stability of blocks with failure mode II-2(that is, sliding on a single sliding surface, but confined by near intersecting line )was deduced.(3)The multi-cavern effect of Laxiwa underground caverns was studied on the assumption that all of the caverns were full face tunneled at the same time.(4)The stability classification scheme of rock mass surrounding large scale underground caverns was established. In addition to inherit the merits of the method of engineering geological
在完成上述工作的过程中,本论文主要在以下几个方面进行了一些探索:①基于空间解析几何原理,提出了块体搜索的基本思路并编制出相应的程序,基本实现了块体搜索的自动化,既大大缩短了块体搜索时间,又能防止因人工搜索引起的遗漏;②推导出Ⅱ-2型(单滑面滑动,但受侧限面约束)块体的稳定性系数计算公式;③以数值模拟方法论证了拉西瓦地下厂房洞室群全断面一次开挖时群洞效应的具体特点;④以岩体质量、开挖效应、群洞效应和次生灾害效应为评价指标,建立了&大型地下洞室群围岩稳定性分类&方案;该方案既继承了水电行业规范&围岩工程地质分类&法的优点,又综合考虑了大型地下洞室群的工程特点。
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The results showed that when 0.3 g of divinyl benzene was used as crosslinking agent, the crosslinking degree increased significantly from 28.26% to 90.95% with the increase of MAA amount from 4.0 mol% to 10.0 mol%, and this increase became slowly as MAA amount was more than 10.0 mol%; the particle volume expansion was increased gradually as MAA amount increased, and reached a maximum of 42.1% when 12.0 mol% of MAA was used, and perfect porous morphology inside particles was observed even when the crosslinking degree reached 95.4% at 14.0 mol% of MAA.
结果表明:在交联剂二乙烯基苯用量一定(0.3 g)的条件下,随着MAA用量从4.0 mol%增加到 10.0 mol%,聚合物交联程度从28.26%迅速增大至90.95%,当其用量超过10.0 mol%后 P x增大趋势变缓;随着MAA用量的增加,处理后胶粒体积膨胀百分率逐渐增大,在MAA用量为12.0 mol%时Δ V 达到42.1%的最大值,当MAA用量增大到14.0 mol%时,尽管 P x高达95.44%,胶粒仍具有完好的孔状结构。
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Results: The normal rate of children in Taiyuan was 62.13%, overweight rate was 13.83%, obesity rate was 10.67%, slight dystrophia rate was 12.32%, mild dystrophia was 1.05%.
结果: 太原市少年儿童的体重正常率为62.13%,有13.83%的少年儿童超重,10.67%的少年儿童肥胖,12.32%的少年儿童有轻度营养不良,1.05%的少年儿童有中度营养不良。
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After selective extraction, the cyst wall of two kind of resting cysts displayed a filament network. In the resting cysts of Tachysoma pellionella and Euplotes encysticus, the filament was located in mesocyst and endocyst respectively. On the other hand, a special filament scaffold region was observed below the cyst wall in two kind of cysts. Compared with the true IF which was located in central part of cyst, the filament of this region was net as well as uniform, and no any cytoplasm residue can be seen in this region. In the resting cyst of Euplotes encysticus, a filamental boundry which partitioned the special filament scaffold region and the true IF region was observed.
两类休眠包囊的包囊壁经生化分级抽提后均显示纤维结构,急纤虫休眠包囊中纤维定位于中间层,包囊游仆虫休眠包囊中纤维定位于内层壁;其次,在两类休眠包囊的包囊壁下,相当于细胞质表质层的位置,均有一个特殊的纤维网络区,与细胞质深层的网络区相比,此部分的纤维纯净、均匀,未见附着细胞器及细胞质残留物,在包囊游仆虫休眠包囊中此纤维网络区与真正的细胞质纤维网络之间由纤维构成的界膜隔开。
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ELISA method was used for comparison. Results The positive rate of DIGFA in testing the serum from 50 infected rats was 96.0%(48/50). The negative rate of DIGFA in healthy rats was 100%(50/50). Cross reaction with Enteroclysis (13 samples) and Tapeworm (11 sqamples) was not observed. The cross reaction rate in 18 Strongyloidiasis rats was 5.6%. The sensitivity and specificity of DIGFA is comparable with ELISA (96.7%).
结果 用DIGFA检测广州管圆线虫实验感染鼠血清50份,其阳性检出率为96.0%,50份正常鼠血清的阴性符合率达100%,DIGFA分别检测蛲虫阳性鼠血清13份,绦虫阳性鼠血清11份和粪类圆线虫阳性鼠血清18份,前二者均为阴性,后者交叉反应率为5.6%;DIGFA与ELISA平行检测30份广州管圆线虫阳性鼠血清,两法符合率达96.7%。
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INTERVENTIONS: Embryonal 14-day SD retina was transplantedin-between the epithalamus and hypothalamus of the midbrain in P1 rat and the right eye of the P1 rat was removed simultaneously. The development time of TP on the 9th day after operation was corresponding to the normal retina on the 1st day after born, which was then recorded as TP1, and so on. The development and differentiation was shown by histochemical method.
干预:用胚14 d SD大鼠视网膜移植至P1大鼠中脑左侧上、下丘间,同时摘除P1鼠右眼,术后第9天移植视网膜的发育时间与生后第1天正常视网膜相当,记为TP1,余类推,应用组织化学方法显示神经元的发育和分化。
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Conclusion1 Critically ill patients with indwelling catheters were of the high positive rate of microorganisms,and microorganism spectrum was of special properties;BF formed mainly inside the catheter,the occurrence rate of BF inside the catheter was high and the formation time was short;Changes on catheters and the result of microorganisms was positively correlated with the BF formation.2 Indwelling catheter time was the independent risk factors for the BF formatiom, while age、APACHEⅡscore、sex、urine sugar and the types of antibiotic usage were the potential risk factors for the BF formation;Nurses should perfect the catheter measures for critical ill patients,emphasis on the assessment of risk factors of BF formation,and implement special care in high-risk patients.3 In the early stage of BF formation,irrigation could play the role of eradicative BF effectively;While later,it couldn't,but it can delay the speed of BF formation and maturation;In the choice of washing methods,injection type washing method is superior to infusion.
结论1重危患者留置尿管微生物培养阳性率高,且微生物菌谱具有特殊性;重危患者尿管表面BF主要在尿管内壁形成;内壁BF的发生率高,形成时间短;肉眼观察尿管表面改变情况以及微生物鉴定结果与BF形成呈正相关。2尿管留置时间是重危患者留置尿管表面BF形成的独立危险因素;年龄、APAcHEⅡ评分、性别、尿糖定性以及抗生素使用种类是其可能的危险因素;护理过程中应完善重危患者尿管护理措施,注重对BF危险因素的评估,并对高危患者实施重点护理。3 BF形成早期,冲洗能发挥较好的清除作用;BF形成后期,冲洗无法彻底清除尿管表面BF,但冲洗能延缓BF形成与成熟的速度;在冲洗方式的选择上,注洗式冲洗法对尿管BF的清除效果优于输注式冲洗法。
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The results showed that the content of ursolic acid in Hedyotis diffusa Willd was 0.896 %, which was the highest in the three medicines,and that in Eriobotrya japonica L indl was 0.843%,which was a bit low,that in Ligustrum lucidum Ait1 was 0.436 %, the lowest in the three.
因为脾为气血生化之源,全身的肌肉都依靠脾胃所运化的水谷精微濡养,因此人体肌肉的丰满强健和消瘦痿弱与脾之运化功能息息相关,人体的四肢,同样需要脾气输送营养。
- 相关中文对照歌词
- When Everything Was What It Was
- Sun Was High (So Was I)
- Jesus Was Our Saviour And Cotton Was Our King
- Before There Was Atlanta, There Was Douglasville
- Phil Cosby (Before There Was Atlanta, There Was Douglasville)
- I Didn't Say I Was Powerful, I Said I Was A Wizard
- All I Was Looking For Was You
- Hò Bha Mi, Hé Bha Mi (Hò I Was, Hè I Was)
- The Moon Was Yellow (And The Night Was Young)
- Stella Was A Diver And She Was Always Down
- 推荐网络例句
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Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.
在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。
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In fact,I've got him on the satellite mobile right now.
实际上 我们已接通卫星可视电话了
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The enrich the peopling of Deng Xiaoping of century great person thought, it is the main component in system of theory of Deng Xiaoping economy, it is a when our country economy builds basic task important facet.
世纪伟人邓小平的富民思想,是邓小平经济理论体系中的重要组成部分,是我国经济建设根本任务的一个重要方面。