查询词典 veratridine

BmK IT2 associateed with and dissociated from its binding sites on insect synaptosomes quickly in two phase kinetic manner, and its specific binding was independence of membrane potential, but could be significantly inhibited by native BmK IT2, BmK AS and BmK AS-1 in a dose-dependent manner, and only partially by BmK Ⅰ or veratridine at high concentration.

BmK IT2能以两相动力学方式快速与昆虫突触体结合和解离，且其结合不依赖于膜电位，可分别被天然毒素BmK IT2，BmK AS和BmK AS-1剂量依赖地抑制，另也可被高浓度BmK Ⅰ和藜芦碱部分抑制。

In the same neuron, veratridine (1.5～5.0 μmol/L) caused slow wave oscillations of interspike intervals, while aconitine (10～200 μmol/L) caused tonic firing.

结果发现，在同一神经元，藜芦碱(1.5～5.0 μmol/L)可以引起放电峰峰间期的慢波振荡，即峰峰间期由大逐渐减小，然后又逐渐增大，形成重复的振荡波形，每个振荡持续约数十秒至数分钟；而乌头碱(10～200 μmol/L)则引起强直性放电，即峰峰间期逐渐减小，然后维持在一个稳定的水平。

Methods By means of whole-cell patch clamp technique, the epileptiform discharge model of rats hippocampal CA1 neurons was constructed with extracellular perfusion of 0.5 μmol/L veratridine, and the model should be regarded as successfully estabilshed if bursting discharge emerged within 30 min perfusion.

通过膜片钳全细胞记录技术，胞外灌流0.5μmol/L藜芦碱，制作大鼠海马CA1锥体神经元癫痫样放电模型，如果在灌流30min内出现振荡样放电，即认为造模成功。

As noted above,membrane-stabilizers unexpectedly improved the heart function andprevented ER stress both in vivo and in cultured cells.We know that the membranestability depends on the sodium homeostasis in fact.To investigate whether ER stress isassociated with sodium channel action,which determins the membrane stability,wepretreated H9c2(2-1) cells with veratridine,a sodium channel activator.

上面的研究发现膜稳定剂在体内体外均抑制了内质网应激，并改善了心脏功能，而膜稳定作用实际上是维持细胞钠离子稳态的结果，为了研究内质网应激反应与钠离子活动的关系，我们用一种钠通道激活剂藜芦定刺激H9c2(2-1)细胞，30分钟时GRP78表达增加；24小时时PERK磷酸化和CHOP蛋白表达显著增加，说明钠离子通道过度激活诱发了内质网应激反应。

Radiolabeled pharmacological binding assay showed: 1 BmK AS bound specifically to a single class of non-interacting binding sites on both rat brain and cockroach nerve cord synaptosomes with high affinity and low low capacity. The association of BmK AS with both synaptosomes was quick to reach equilibrium, but the dissociation seemed to be only partial. The specific binding of BmK AS was independent of membrane potential, and couldn't be modified by veratridine. Moreover, the binding of BmK AS could be inhibited by native BmK AS, BmK AS1, BmK IT2 and BmK IT on both synaptosomes, but not or partially inhibited by BmK Ⅰ and suggesting BmK AS type neurotoxins might bind to a distinct receptor site on mammal and insect sodium channels with a similar manner from β-scorpion toxins.

二。蝎毒素多肽配体与哺乳动物和昆虫靶离子通道受体的药理结合特性及其靶结合位点的研究：经放射性标记结合和竞争抑制实验表明：1）BmK AS在大鼠脑和蟑螂神经索突触体上有单一非协同性高亲和力低结合容量结合位点，能快速结合并达到平衡，但仅能部分解离，其结合不依赖于膜电位，也不受藜芦碱调节，天然的BmK AS，BmK AS-1，BmK IT2和BmK IT可抑制〓AS与两种突触体的特异结合，而BmK Ⅰ无或仅有部分抑制效应。

During the pests happened heavily, field toxicity were experimented to control the larvae of Liriomyza huidobrensis Blanchard with abamectin, veratridine, matrine, pyrethrum+matrine, azadirachtin, chlorpyrifos and imidacloprid.

在南美斑潜蝇发生较重时期，利用阿维菌素EC、苦参碱EC、除虫菊素+苦参碱EC、印楝素EC、毒死蜱EC、吡虫啉WP等8种农药防治大田中的南美斑潜蝇。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。