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To solve the problem and improve the safety of gene therapy, we used microencapsule, a insulation tool of cell transplantation immunity, to encapsule human fibroblastlike bone marrow stroma cells transfected by part of CEA gene and produced microencapsulated CEA transgeneic cell vaccines; we also studied the expression of vaccine in mouse body as well as its immunologic characteristics.

为解决上述问题、提高基因治疗的安全性,本研究采用细胞移植免疫用隔离工具-微胶囊包裹转染部分CEA基因的人成纤维样骨髓基质细胞HFCL,制备出CEA微囊化转基因细胞疫苗,并进行了疫苗在小鼠体内的表达及其免疫学性质的研究,探讨该疫苗应用于CEA阳性肿瘤治疗的可能性,并为进一步的临床应用研究奠定了基础。

But the major shortcoming of these vaccines is the disability to induce cellular immunity, which is essential for eliminating the endocellular virus and breaking immunologic tolerance which exist widely in chronic hepatitis B patients.

但此类疫苗最大的缺点是不能诱导有效的细胞免疫,而细胞免疫在清除细胞内病毒,以及打破慢性乙肝患者持续的免疫耐受状态具有极其重要的作用。

The pre erythrocytic stage vaccines aim to prevent the development of all clinical symptoms and subsequent malaria transmission. Erythrocytic stage vaccine designed aims to induce antibodies that prevent invasion and infection of erythrocytes, to reduce morbidity and mortality by decreasing the parasite load.

作用于红细胞前期的疟疾疫苗主要是抑制疟疾的临床发作,控制疟疾的传播;作用于红细胞期的疟疾疫苗诱导宿主体液免疫系统,产生特异性抗体,抑制疟原虫侵入和感染红细胞,达到减少疟原虫虫荷,降低疟疾的发病率和死亡率。

Objective To explore the feasibility of treatment with dendritic cell vaccines in lung cancer hematogenous metastasis.

摘 要:目的探索应用树突状细胞肿瘤疫苗治疗肺癌血源性转移的可能性。

As an advocate for vaccines, she has received both travel expenses and honoraria from Merck, the developer of the chicken pox vaccine

在她的儿子死于水痘后,她支持疫苗,她并因此接受MERCK公司为她支付她的旅行费用和奖金。

These results indicate that hydrostatic pressure may provide a novel efficient physical means of preparing antiviral vaccines.

这些结果表明,高压力可能成为制备IBDV疫苗的一种新方法。

The high sensitivity and specificity of real time RT-PCR were shown by The test result, 10~7 of the diluted allantoic fluid infected by AIV can also be detected, and has no cross-reaction with common Avian virus and Avian vaccines, such as low virulent NDV and IB V vaccine.5 days after the broiler has been injected with AIV vaccine, no matter hypodermal or muscular injection, the real time RT-PCR has not found any AIV nucleotide, indicating the use of AIV vaccine has no effect on the test results.

在检测禽流感感染的尿囊液时,尿囊液稀释至10~(-7)仍可检出病毒核酸,荧光RT-PCR方法的特异性也很强,检测时与禽群常用的疫苗如新城疫弱毒疫苗、传染性支气管炎弱毒疫苗等均不出现交叉反应。

This path seems to be promising for future development of vaccines against Ich.

这将成为未来抗小瓜虫疫苗的开发方向。

The eukaryotic expression plasmids were used as genetic vaccines to immunized intramuscularly experimental animals and post-weaning piglets.

同时还研究证明猪白细胞介素2和6基因对猪伪狂犬病核酸疫苗的免疫增效作用。

These investigational vaccines have also been shown to be safe and effective in children and healthy working adults.

经研究发现,这些疫苗对儿童和健康成人都是安全有效的。

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