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Nucleoprotein is also a major immunogenetic antigen for SARS; however, several tests have shown that N protein had the reactivity with other coronavirus positive sera. It is therefore an advantage of S protein as recombinant target antigen for SARS serum diagnosis compared with recombinant N protein. Moreover, S protein has been shown to be the major antigenic determinant that induces neutralizing antibodies and protective immunity to SARS-CoV, so it is also important in designing SARS genetic engineering vaccine.

SARS-CoV S 蛋白由1255 个氨基酸组成,体外表达如此大的蛋白很困难,而且表达蛋白的可溶性不高;其次,实验已经证实,全长S 蛋白含有大量无关的表位,致使表达的全长S蛋白对SARS 阳性血清的检出率低于S 蛋白片段;另外作为疫苗研究,S 蛋白上大量无关表位作为异体蛋白进入体内,会引发机体的过度免疫反应,这也是SARS-CoV 可能的致病机理之一。

Our trial suggests that an H5N1 vaccine manufactured and formulated with both of these approaches is well tolerated and immunogenic.

我们的试验表明使用这两种方法生产的H5N1疫苗安全性和免疫原性良好。

They are immunogenic and were processed into the first commercial vaccine against HBV.

它们有免疫原性并首次加工为商业用乙肝疫苗(图29-1)。

This he said is aimed at ensuring that at its every new stage, the vaccine is not only immunogenic (doing what it is supposed to do), but that it is not toxic and it should at the same time elicit or induce effective immune responses.

他说这是为了确保在每一个新的阶段,该疫苗不仅是免疫原性,但它不是有毒,并应在同一时间征求或诱导有效的免疫反应。

An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine.

将一种西尼罗河病毒或质粒DNA的免疫原性活性成分、一种诸如可代谢油的佐剂和一种药学可接受载体共同配制成一种免疫疫苗。

Dendritic cell vaccine was impacted and sensitized by tumor associated antigen and antigen polypeptide in vitro, then was retransfused or immunogenically inoculated to tumour carrier host, can evoked specific CTL's antitumour immunoreaction.

应用肿瘤相关抗原或抗原多肽体外冲击致敏DC制成疫苗,回输或免疫接种于载瘤宿主,可诱发特异性CTL的抗肿瘤免疫反应。

Gates expresses,"Bill and Meilinda Gaicijijinhui " ever contributed a help of 150 million dollar to solve the vaccine that finds poison of the disease that fight impaludism last year.

盖茨表示,&比尔及梅林达·盖茨基金会&去年曾捐款1.5亿美元帮助解决找到抗疟疾病毒的疫苗。

It was very impossible that those mutations of GX epidemic strains of CSFV can cause the incompleted protection of HCLV vaccine.

GXLZ与GXNN和HCLV、Shimen的氨基酸序列对比发现,在E_2基因B、C高变的抗原区,GXLZ、GXNN在710、713、725、孙石静:广西猪瘟流行毒株E。

Objective: To evaluate the long-term toxicity of intramuscularly injected typhoid conjugate vaccine in Sprague-Dawley rats.

伤寒Vi结合疫苗对大鼠有明显的免疫原性,但无明显毒性和局部刺激性。

In the second test, another group of bigger turbot fries were vaccinated with formalin-killed vaccine of V.anguillarum via intraperineal injection.

第二次试验中,鱼苗较大,水温12-16℃,以福尔马林灭活的鳗弧菌W-1疫苗注射免疫大菱鲆鱼苗,于8周后同法进行二次免疫。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。