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OBJECTIVE: To construct a prokaryotic expression plasmid of the main catalytic domain of dipeptidyl peptidase of murine fibroblast activation protein αand obtain the target fusion protein in order to provide basis for production of antibodies and anti-tumor vaccine targeting FAPα.

目的:构建小鼠成纤维细胞激活蛋白α二肽基肽酶催化核心序列的高效原核表达载体,进行该序列的原核表达、纯化和复性,为下一步高效抗体制作和以FAPα为靶标的抗肿瘤疫苗研发提供实验基础。

In 1987, 66 victims of the Japanese pertussis vaccine won huge awards from their government.

在1987年,66名日本百日咳疫苗的受害者从政府获得了巨大的赔偿。

Scientists also developed an indirect test to determine the efficacy and safety of the pertussis vaccine.

科学家还改良了一种间接的测试来确定百日咳疫苗的有效性和安全性。

In 1981, Japan began giving their children a new "acellular" pertussis vaccine.

1981年,日本开始给他们的孩子接种一种新的"非细胞"百日咳疫苗。

Pertussis is one of the leading causes of vaccine-preventable deaths world-wide.

百日咳是世上疫苗可防性的致死主要病因之一。

Most infants receive a pertussis vaccine, but its effectiveness subsides after about 10 years.

大多数婴儿会接受百日咳疫苗的接种,但是在十年后效果会降低。

The United States never conducted its own clinical tests to determine whether the pertussis vaccine is safe and effective.

美国从来都没有进行临床试验来决定百日咳疫苗是否安全有效。

However, in 1975, a few years before the new pertussis vaccine was introduced in Japan, authorities raised the age of vaccination to two years.

然而,在新的百日咳疫苗在日本使用前几年的1975年,权威机构将接种的年龄提到了两岁。

A vaccine against pertussis has been available since 1936 (and was put into general use during the 1940s).

自从1936年来,一种预防百日咳的疫苗发明了(并在1940年代投入广泛的使用)。

Which laid a molecular immunological foundation of developing candidate antigen of pertussis vaccine.

为研制百日咳疫苗候补抗原的相关分子免疫学研究奠定了基础。

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