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This appear'd so clear to me now, that nothing was a greater Satisfaction to me, than that I had not been suffer'd to do a Thing which I now saw so much Reason to believe would have been no less a Sin, than that of wilful Murther, if I had committed it; and I gave most humble Thanks on my Knees to God, that had thus deliver'd me from Blood-Guiltiness; beseeching him to grant me the Protection of his Providence, that I might not fall into the Hands of the Barbarians; or that I might not lay my Hands upon them, unless I had a more clear Call from Heaven to do it, in Defence of my own Life.

现在，事情在我看来已经非常清楚了。我觉得，上帝没有让我干出这件事来，实是一件最令我庆幸的事情。我认识到，我没有任何理由去干这件事；如果我真的干了，我所犯的罪行无异于故意谋杀。于是我跪下来，以最谦卑的态度向上帝表示感谢，感谢他把我从杀人流血的罪恶中拯救出来，并祈祷他保佑我，不让我落入野人手里，以防止我动手伤害他们；降非上天高声召唤我，让我为了自卫才这样做。

But that did not altogether press meso much as the possibility that there might be yet some livingcreature on board, whose life I might not only save, but might, bysaving that life, comfort my own to the last degree; and thisthought clung so to my heart that I could not be quiet night orday, but I must venture out in my boat on board this wreck; andcommitting the rest to God's providence, I thought the impressionwas so strong upon my mind that it could not be resisted - that itmust come from some invisible direction, and that I should bewanting to myself if I did not go.

我上面说了，我的样子狰狞可怕；我的仆人星期五远远地跟在我后面，也是全副武装，样子像我一样可怕，但比我稍好一些，不像我那样，像个怪物。我悄悄走近他们，还没等到他们看见我，我就抢先用西班牙语向他们喊道："先生们，你们是什么人？"一听到喊声，他们吃了一惊，可一看到我的那副怪模样，更是惊恐万分，连话都说不出来了。我见他们要逃跑的样子，就用英语对他们说："先生们，别害怕。也许，你们想不到，在你们眼前的人，正是你们的朋友呢！""他一定是天上派下来的，"其中一个说，并脱帽向我致礼，神情十分认真。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

He bid me observe it, and I should always find , that the calamities of life were shared among the upper and lower part of mankind; but that the middle station had the fewest disasters, and was not exposed, to so many vicissitudes as the higher or lower part of mankind; nay, they were not subjected to so many distempers and uneasiness either of body or mind, as those were who, by vicious living, luxury and extravagancies on one hand, or hard labour, want of necessaries, and mean or insufficient diet on the other hand, bring distempers upon themselves by the natural consequences of their way of living; that the middle station of life was calculated for all kind of virtues and all kinds of a middle fortune; that temperance, moderation, quietness, health, society, all agreeable diversions, and all desirable pleasures, were the blessing attending the middle station of life; that this way men went silently and smoothly through the world, and comfortably out of it, not embarrassed with the labour of the hands or of the head, not sold to the life of slavery for daily bread, or harassed with perplexed circumstances, which rob the soul of peace, and the body of rest; not enraged with the passion of envy, or secret burning lust of ambition for great things; but in easy circumstances sliding gently through the world, and sensibly tasting the sweets of living, without the bitter, feeling that they are happy, and learning by every day's experience to know it more sensibly.

他嘱咐我，只要用心观察，到处都可发现：生活的灾难是由上层和下层两类人分担，而中间阶层灾难最少，不会像那两类人那样，要经历那么多的荣辱变迁，商海浮沉。中间阶层也绝不会像阔佬那样，因骄奢淫逸、挥霍无度而狂躁不安、身心俱损；也不会像穷人那样，因劳累辛苦、缺吃少穿，以及这种穷苦生活自然而然带来的种种后果而焦急不安、忧心忡忡。他说，中等生活最能保持各种美德和一切正常而适中的享受，中等人的生活经常是安定富足的。他说，和睦和富裕是中产阶层的随身伴侣。他说，和善、谦虚、宁静、健康、社交、各种正当的娱乐、各种有益的消遣，都是降临到中等人头上的福份。他们就这样默默地、但又是顺利地、当然也是舒服地走过人生的旅途，不受劳力和劳心之苦，也不必为每天的面包而卖身为奴，或被困境搞得身心疲惫；也不会因心怀嫉妒和好大喜功而野心勃勃、贪婪无度，而是在轻松的环境下平静地度过一生，有意识地品尝着生活的甜美，没有痛苦，只感到幸福，并且通过日益增多的经验，越来越有意识地去学会品尝和感受幸福。

He bid me observe it, and I should always find, that the Calamitles of Life were shared among the upper and lower Part of Mankind; but that the middle Station had the fewest Disasters, and was not exposd to so many Vicisitudes as the higher or lower Part of Mankind; nay, they were not subjected to so many Distempers and Uneasiness either of Body or Mind, as those were who, by vicious Living, Luxury and Extravagancies on one Hand, or by hard Labour, Want of Necessaries, and mean or insufficient Diet on the other Hand, bring Distempers upon themselves by the natural Consequences of their Way of Living; That the middle Station of Life was calculated for, all kind of Vertues and all kinds of Enjoyments; that Peace and Plenty were the Hand-maids of a middle Fortune; that Temperance, Moderation, Quietness, Health, Society, all agreeable Diversions, and all desirable Pleasures, were the Blessings attending the middle Station of Life; that this Way Men went silently and smoothly thro the World, and comfortably out of it, not embarassd with the Labours of the Hands or of the Head, not sold to the Life of Slavery for daily Bread, or harrast with perplexd Circumstances, which rob the Soul of Peace, and the Body of Rest; not enragd with the Passion of Envy, or secret burning Lust of Ambition for great things; but in easy Circumstances sliding gently thro the World, and sensibly tasting the Sweets of living, without the bitter, feeling that they are happy, and learning by every Days Experience to know it more sensibly.

他说，我自己可以从下面的事实中认识到，中间地位的生活确实幸福无比；这就是，人人羡慕这种地位，许多帝王都感叹其高贵的出身给他们带来的不幸后果，恨不得自己出生于贫贱与高贵之间的中间阶层。明智的人也证明，中间阶层的人能获得真正的幸福。《圣经》中的智者也曾祈祷：&使我既不贫穷，也不富裕。&他提醒我，只要用心观察，就会发现上层社会和下层社会的人都多灾多难，唯中间阶层灾祸最少。中间阶层的生活，不会像上层社会和下层社会的人那样盛衰荣辱，瞬息万变。而且，中间地位不会像阔佬那样因挥霍无度、腐化堕落而弄得身心俱病；也不会像穷人那样因终日操劳、缺吃少穿而搞得憔悴不堪。唯有中间地位的人可享尽人间的幸福和安乐。中等人常年过着安定富足的生活。适可而止，中庸克己，健康安宁，交友娱乐，以及生活中的种种乐趣，都是中等人的福份。这种生活方式，使人平静安乐，怡然自得地过完一辈子，不受劳心劳力之苦。他们既不必为每日生计劳作，或为窘境所迫，以至伤身烦神；也不会因妒火攻心，或利欲薰心而狂躁不安。中间阶层的人可以平静地度过一生，尽情地体味人生的甜美，没有任何艰难困苦；他们感到幸福，并随着时日的过去，越来越深刻地体会到这种幸福。

He bid me observe it, and I should always find, that the Calamitles of Life were shared among the upper and lower Part of Mankind; but that expos'd to so many Vicisitudes as the higher or lower Part of Mankind; nay, they were not subjected to so many Distempers and Uneasiness either of Body or Mind, as those were who, by vicious Living, Luxury and Extravagancies on one Hand, or by hard Labour, Want of Necessaries, and mean or insufficient Diet on the other Hand, bring Distempers upon themselves by the natural Consequences of their Way of Living; That the middle Station of Life was calculated for, all kind of Vertues and all kinds of Enjoyments; that Peace and Plenty were the Hand-maids of a middle Fortune; that Temperance, Moderation, Quietness, Health, Society, all agreeable Diversions, and all desirable Pleasures, were the Blessings attending the middle Station of Life; that this Way Men went silently and smoothly thro' the World, and comfortably out of it, not embarass'd with the Labours of the Hands or of the Head, not sold to the Life of Slavery for daily Bread, or harrast with perplex'd Circumstances, which rob the Soul of Peace, and the Body of Rest; not enrag'd with the Passion of Envy, or secret burning Lust of Ambition for great things; but in easy Circumstances sliding gently thro' the World, and sensibly tasting the Sweets of living, without the bitter, feeling that they are happy, and learning by every Day's Experience to know it more sensibly.

就我的社会地位而言，正好介于两者之间，即一般所说的中间地位。从他长期的经验判断，这是世界上最好的阶层，这种中间地位也最能使人幸福。他们既不必像下层大众从事艰苦的体力劳动而生活依旧无着；也不会像那些上层人物因骄奢淫逸、野心勃勃和相互倾轧而弄得心力交瘁。他说，我自己可以从下面的事实中认识到，中间地位的生活确实幸福无比；这就是，人人羡慕这种地位，许多帝王都感叹其高贵的出身给他们带来的不幸后果，恨不得自己出生于贫贱与高贵之间的中间阶层。明智的人也证明，中间阶层的人能获得真正的幸福。《圣经》中的智者也曾祈祷：&使我既不贫穷，也不富裕。&他提醒我，只要用心观察，就会发现上层社会和下层社会的人都多灾多难，唯中间阶层灾祸最少。中间阶层的生活，不会像上层社会和下层社会的人那样盛衰荣辱，瞬息万变。而且，中间地位不会像阔佬那样因挥霍无度、腐化堕落而弄得身心俱病；也不会像穷人那样因终日操劳、缺吃少穿而搞得憔悴不堪。唯有中间地位的人可享尽人间的幸福和安乐。中等人常年过着安定富足的生活。适可而止，中庸克己，健康安宁，交友娱乐，以及生活中的种种乐趣，都是中等人的福份。这种生活方式，使人平静安乐，怡然自得地过完一辈子，不受劳心劳力之苦。他们既不必为每日生计劳作，或为窘境所迫，以至伤身烦神；也不会因妒火攻心，或利欲薰心而狂躁不安。中间阶层的人可以平静地度过一生，尽情地体味人生的甜美，没有任何艰难困苦；他们感到幸福，并随着时日的过去，越来越深刻地体会到这种幸福。

He bid me observe it, and I should always find, that the Calamitles of Life were shared among the upper and lower Part of Mankind; but that the middle Station had the fewest Disasters, and was not expos'd to so many Vicisitudes as the higher or lower Part of Mankind; nay, they were not subjected to so many Distempers and Uneasiness either of Body or Mind, as those were who, by vicious Living, Luxury and Extravagancies on one Hand, or by hard Labour, Want of Necessaries, and mean or insufficient Diet on the other Hand, bring Distempers upon themselves by the natural Consequences of their Way of Living; That the middle Station of Life was calculated for, all kind of Vertues and all kinds of Enjoyments; that Peace and Plenty were the Hand-maids of a middle Fortune; that Temperance, Moderation, Quietness, Health, Society, all agreeable Diversions, and all desirable Pleasures, were the Blessings attending the middle Station of Life; that this Way Men went silently and smoothly thro' the World, and comfortably out of it, not embarass'd with the Labours of the Hands or of the Head, not sold to the Life of Slavery for daily Bread, or harrast with perplex'd Circumstances, which rob the Soul of Peace, and the Body of Rest; not enrag'd with the Passion of Envy, or secret burning Lust of Ambition for great things; but in easy Circumstances sliding gently thro' the World, and sensibly tasting the Sweets of living, without the bitter, feeling that they are happy, and learning by every Day's Experience to know it more sensibly.

他提醒我，只要用心观察，就会发现上层社会和下层社会的人都多灾多难，唯中间阶层灾祸最少。中间阶层的生活，不会像上层社会和下层社会的人那样盛衰荣辱，瞬息万变。而且，中间地位不会像阔佬那样因挥霍无度、腐化堕落而弄得身心俱病；也不会像穷人那样因终日操劳、缺吃少穿而搞得憔悴不堪。唯有中间地位的人可享尽人间的幸福和安乐。中等人常年过着安定富足的生活。适可而止，中庸克己，健康安宁，交友娱乐，以及生活中的种种乐趣，都是中等人的福份。这种生活方式，使人平静安乐，怡然自得地过完一辈子，不受劳心劳力之苦。他们既不必为每日生计劳作，或为窘境所迫，以至伤身烦神；也不会因妒火攻心，或利欲薰心而狂躁不安。中间阶层的人可以平静地度过一生，尽情地体味人生的甜美，没有任何艰难困苦；他们感到幸福，并随着时日的过去，越来越深刻地体会到这种幸福。

But now, if I be marching on with my utmost vigour in that way which, according to the sacred geography, leads straight to Jerusalem, why am I beaten and ill-used by others because, perhaps, I wear not buskins; because my hair is not of the right cut; because, perhaps, I have not been dipped in the right fashion; because I eat flesh upon the road, or some other food which agrees with my stomach; because I avoid certain by-ways, which seem unto me to lead into briars or precipices; because, amongst the several paths that are in the same road, I choose that to walk in which seems to be the straightest and cleanest; because I avoid to keep company with some travellers that are less grave and others that are more sour than they ought to be; or, in fine, because I follow a guide that either is, or is not, clothed in white, or crowned with a mitre?

但是现在，如果我正依据那个引导人到耶路撒冷的神圣地理学劲头十足的开始我的长途跋涉，为什么要被他人暴力虐待和折磨？可能因为：我没有穿高统靴；或者我的头发未按某种样式修剪；或者我未按某种方式受洗；或者在路上我吃了肉或其它很对我胃口的食物；或者我绕开了一段在我看来要导向荆棘或悬崖的路；或者在几条通向目的地的路中我选了一条在我看来最近最好走的路；或者我避免与不怎么严肃的人以及过于酸腐的人为伴；或者，最后，因为我跟随了一个穿或未穿白衣，戴或未戴主教头冠的人。

The major findings are:⑴During the intelligence test for the three groups of students, for half of the students or most of the students their scores on the all-including scale, the language scale and the performance scale all increased to various degrees;⑵From the analysis of the relationship between intelligence and reaction time, it is found that the result of this study confirms the existing views that there is a negative correlation between intelligence and reaction time, and the negative correlation is more evident when it is choice reaction time;⑶Different motor skills have different influences upon children with lower intelligence. Though the difference is not large, the average increasing percentages in the sample T tests for the three groups before and after the experiment show that the effect of open motor skill is the best, that of the synthetic motor skill or the open-closed is the better, and that there isn't a marked change in the closed motor skill trainees;⑷While analyzing the result of the experiment, it is found that the scores on the performance scale are higher than the scores on the language scale, especially in the open motor skill group, which tells us that the intelligence improving effect of physical training is realized to a greater extent through increasing their performance abililty.

研究结果显示：⑴相对于实验前测试结果，三个实验组学生的智力水平在实验后测试中不论是在全量表得分还是在语言量表、操作量表得分方面均得到了不同程度的提高；⑵从智力与反应时的相关分析可看出，本研究结果进一步验证了前人观点，即智力与反应时有显著的负相关，特别是与选择反应时有很强的负相关性；⑶不同运动技能对智力落后学生智力影响不同，虽然实验后各组间没有显著性差异，但经各组实验前后配对样本T检验及实验前后各项分数均值提高百分率可看出，开放式运动技能组实验效果最好，综合运动技能组次之，闭锁式运动技能组实验前后在智力测验量表得分上无显著性变化；⑷各组实验前后的操作量表分比言语量表分提高幅度更大，开放式运动技能组表现得尤其显著，这表明了体育活动对改善智力落后学生的智力水平，很大程度上是通过提高他们的操作能力来实现的。

I have been in all my Circumstances a Memento to those who are touch'd with the general Plague of Mankind, whence, for ought I know, one half of their Miseries flow; I mean, that of not being satisfy'd with the Station wherein God and Nature has plac'd them; for not to look back upon my primitive Condition, and the excellent Advice of my Father, the Opposition to which, was, as I may call it, my ORIGINAL SIN; my subsequent Mistakes of the same kind had been the Means of my coming into this miserable Condition; for had that Providence, which so happily had seated me at the Brasils, as a Planter, bless'd me with confin'd Desires, and I could have been contented to have gone on gradually, I might have been by this Time; I mean, in the Time of my being in this Island, one of the most considerable Planters in the Brasils, nay, I am perswaded, that by the Improvements I had made, in that little Time I liv'd there, and the Encrease I should probably have made, if I had stay'd, I might have been worth an hundred thousand Moydors; and what Business had I to leave a settled Fortune, a well stock'd Plantation, improving and encreasing, to turn Supra-Cargo to Guinea, to fetch Negroes; when Patience and Time would have so encreas'd our Stock at Home, that we could have bought them at our own Door, from those whose Business it was to fetch them; and though it had cost us something more, yet the Difference of that Price was by no Means worth saving, at so great a Hazard.

一般人往往有一种通病，那就是不知足，老是不满于上帝和大自然对他们的安排。现在我认识到，他们的种种苦难，至少有一半是由于不知足这种毛病造成的。患有这种病的人大可以从我的一生经历中得到教训。就拿我自己来说吧，正是由于我不满自己原来的境况，又不听父亲的忠告--我认为，我有悖教训，实为我的&原罪&，再加上我后来又犯了同样的错误，才使自己落到今天这样悲惨的地步。当时，造物主已安排我在巴西做了种植园主。如果我自己不痴心妄想发财，而是满足于逐渐致富，这时候我也许已成了巴西数一数二的种植园主了，而现在我却白白地在这荒岛上流落了这么多年，过着悲惨孤寂的生活。而且，我在巴西经营时间不长；就是在这段短短的时间里，我也获利不少。因此我确信，要是我继续经营下去的话，到现在一定拥有十几万葡萄牙金币的家财了。当时，我的种植园已走上了轨道，并且日益兴旺。可是，我偏偏把这一切丢弃，甘愿去当一名船上的管货员，只是为了到几内亚去贩卖黑奴。现在想来，我为什么要这样做呢？要是我守住家业，只要有耐心，经过一段时间之后，同样可以积聚大笔财富，我不是也可以在自己的家门口，从那些黑奴贩子手里买到黑奴吗？虽说价钱贵一点，但这点差价绝不值得自己去冒这样大的风险！

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。