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It has been well documented that the fibular collateral ligament is the primary varus stabilizer of the knee.8,10 Consequently, isolated FCL injuries can elicit abnormal varus knee instability that can lead to functional limitations, a varus thrust gait pattern, and the potential development of medial meniscal tears or medial compartment arthritis over time due to the increased compressive forces at the medial tibiofemoral compartment.16,23,30 In addition, it has been demonstrated that varus instability, primarily due to a deficient FCL from an untreated posterolateral knee injury, causes a significant increase in force on both anterior cruciate and posterior cruciate ligament reconstruction grafts.11,21,22 Therefore, a reconstruction technique to address nonrepairable acute or chronic isolated FCL tears is important to address these pathologic abnormalities.

已经证实腓侧副韧带是防止膝关节内翻的主要稳定结构[8，10]。因此，FCL离断伤可以引起异常的膝关节内翻不稳定，从而导致功能受限、膝内摆步态和潜在发展为内侧半月板撕裂或由于在增加胫股关节间隙的压力会随时间推移发生内侧间室关节炎[16， 23， 30]。此外，已经证实了主要由膝关节后外侧损伤后未经治疗导致FCL功能缺陷引起的膝内翻不稳可以引起前交叉韧带和后交叉韧带重建移植物受力明显[11，21，22]。因此，认为不可修复的急性或慢性FCL离断撕裂伤的重建技术对这些病理异常非常重要。

Full-thickness cartilage defects, 0.5cm×0.5cm in size, were created at superior and lower area of femur trochlear in eight porcins (16 knees, 32 defects in all), the lesions in the right knees were untreated or treated by periosteum , the left knees were served as ACI groups (including monolayer and polylayer culture group), each defect was distributed into every control groups and every treated groups randomly.

在8头猪（16膝）股骨髁髌切迹上下各建立一个0.5cm×0.5cm大小的全层软骨缺损（共32个缺损），右膝为空白对照组和自体骨膜移植对照组，左膝为单层培养细胞组和复层培养细胞组，上下缺损随机进入各对照和试验组。

Avoid drinking untreated tap water and ice, local and uncapped bottled water.

避免饮用未经处理的自来水和加冰饮料已经当地没有平改包装的水。

To find the highly efficient biological treatment conditions was found the results showed that ultrasound treatment and after biological treatment Uncaria alkali content than the untreated materials have been significantly improved, and the yeast of fermentation to deal with the rhynchophylline is the highest yield.

结果表明，经超声处理和生物方法处理后钩藤碱含量较未经处理材料有了显著提高，其中以酵母发酵处理钩藤碱收率最高。

Furthermore, preliminary work also performed to examine whether PI3K/AKT signal transduction pathway was activated in the process of refractory leukemia development. Materials and methods An immortalized human bone marrow stromal cell line, HS-5, was introduced to establish a bi-phase culture system for the cultivation of B-lineage precursor leukemia cells. ELISA and RT-PCR were used to investigate the expression of VEGF and its receptors in the leukemia cell lines and primary childhood leukemia cells in different treated groups. Flow cytometory method and immunofluorescent staining were employed to examine the apoptosis signals both in the VP16 treated and untreated leukemia cells. Western blot was utilized to explore the PI3K/AKT activated status in the drug induced or uninduced leukemia cells and lymphocytes from healthy donors.

材料和方法使用来源于人类骨髓基质细胞的细胞株HS-5作为滋养层细胞进行急性淋巴细胞性白血病细胞的体外培养，通过细胞生物学和免疫学方法评估培养体系并鉴定出难治性白血病细胞克隆；以ELISA和RT-PCR方法检测急性白血病细胞株和患儿白血病细胞VEGF及其受体的表达，了解不同治疗阶段VEGF及其受体的表达状况，并结合临床指标进行分析，明确VEGF及其受体在白血病发生过程中的作用；流式细胞仪和免疫荧光染色法对正常健康儿童、初发白血病患儿、复发白血病患儿及缓解后患儿进行凋亡因子检测和分析，初步阐明难治性白血病抗凋亡形成的原因；蛋白印记分析检测PI3K/AKT信号传导通路在健康儿童、初发白血病和复发白血病患儿的表达，初步了解难治性白血病形成的分子生物学机制。

The LDH total activity and its isoenzymes patterns of cancer tissue in untreated and recurreut NPC groups were different from those in unrecurrent NPC and benign lesions of heads and necks.

鼻咽癌放疗后复发组血清和组织LDH总酶活力及其同工酶谱均与鼻咽癌初诊组相似，而未复发组则接近于良性病变组，与复发组显著不同。

To determine the effectiveness of combining laser therapy with an immunosuppressive approach, the investigators recruited 14 subjects, aged 12 to 63 years, with Fitzpatrick skin types II to IV and having had vitiligo for a minimum of three months. A total of 43 vitiliginous lesions were randomized to receive either 308-nm excimer laser monotherapy twice weekly for six weeks or the laser sessions plus topical 0.1% tacrolimus ointment applied twice daily. Treated lesions were matched with untreated lesions on the subjects' opposite side.

为了确定结合雷射治疗与免疫抑制方式的效果，研究人员徵集14位受试者，年龄从12到63岁，患有Fitzpatrick皮肤类型II到VI的、而且有白斑至少3个月以上的患者；总共有43个白斑病灶被随机分派接受每周两次的308－nm准分子雷射治疗持续六周，或是雷射治疗加上0.1%局部tacrolimus软膏每天涂抹两次；治疗后的病灶再与受试者另外一边未接受治疗的病灶相比较。

As with many primarily zoonotic diseases, plague is a very severe disease in people, with case fatality rates of 50 %~60 % if left untreated.

如同许多原本是动物传染病那样，鼠疫是一种非常严重的人类疾病，假如得不到治疗，病死率为50%～60%。

As with many primarily zoonotic disease s, plague is a very severe disease in people, with case fatality rates of 50 %~60 % if left untreated.

如同许多原本是动物传染病那样，鼠疫是一种非常严重的人类疾病，假如得不到治疗，病死率为50%～60%。

Left untreated, young children who are long-sighted may eventually lose vision in one eye.

左未处理，幼童谁是长期的眼光，最终可能失去高瞻远瞩，在一只眼睛。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新