查询词典 ubiquinone

The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase is an integral membrane protein complex in both the tricarboxylic acid cycle and aerobic respiration. Complex II comprises of two hydrophilic proteins, flavoprotein and iron-sulfur protein, and two trans-membrane proteins, the molecular weight was 125KDa, as well as prosthetic groups required for electron transfer.

线粒体呼吸链复合物II即琥珀酸泛醌氧化还原酶是一个跨膜蛋白复合物，复合物II由两个亲水蛋白和两个穿膜蛋白构成，总的分子量大约在125kD左右，这里面包含了从琥珀酸到泛醌传递电子所需的电子传递体。

Their biological activity is generally attributable to inhibition of NADH: ubiquinone oxidoreductase activity and thereby mitochondrial respiration.

这一类化合物之所以具有很好的杀虫活性，是由于对还原型烟酰胺腺嘌呤二核甘酸的抑制作用而阻断了线粒体的呼吸。

The DNA sequencing data indicate these clones are ESTs of Cytochrome c oxidase subunit and NADH-ubiquinone oxidoreductase chain 4 gene.

测序提示为细胞色素氧化酶C亚单位和NADH-泛醌氧化酶复合体4链的表达性片段。

Bioinformatics analysis was carried out to obtain the protein and gene sequences of rat NADH -ubiquinone oxidoreductase.

另外，RIKENcDNA 2900053E13与人的NADH-辅酶氧化还原酶（gi4191348，NADH-ubiquinone oxidoreductase 42 kDa subunit有高度同源性。

The differential expression of NADH-ubiquinone oxidoreductase chain 4, one of those 13 subunits of subcomplex β, suggests that subcomplex β may have important function associated with pathophysiologic changs in reperfusion injury.

再灌注损伤后NADH-泛醌氧化酶复合体4链的表达提示原来功能不明的NADH-泛醌氧化酶复合体β亚基可能在这一病理过程中发挥一定的作用。

Ubiquinone-10 supplement increased lesion size and the fraction of lesions containing fibrous caps; however, LDL oxidizability remained unaffected by ubiquinone-10 treatment.

添加泛醌-10能增加损伤面积和包含纤维帽的损伤片断，然而对LDL的氧化不产生影响。

Based on the structure, those human diseases related mutation sites are mapped onto the structure accurately. As a result, it is found that these sites are all around the electron transfer prosthetic groups or ubiquinone. And these mutations will alter prosthetic groups' binding or ubiquinone's binding, causing electron leakage from the prosthetic groups in the electron transfer chain, producing reactive oxygen species and leading to tumor formation.

利用线粒体复合物 II 的结构对已知与人类疾病相关的该复合物突变位点进行了精确定位，发现这些突变位点均位于电子传递体或辅酶 Q 结合位点的周围，它们的突变或影响了电子传递体的结合，或影响了辅酶 Q 的结合，从而导致电子传递的中断，电子逃逸到线粒体基质中或线粒体内膜中，经过一系列下游途径导致疾病的产生。

Drugs of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors family are usually used as a very effective lipid-lowering preparations but they simultaneously block biosynthesis of both cholesterol and ubiquinone Q10, which is an intermediate electron carrier in the mitochondrial respiratory chain. It is known that reduced form of ubiquinone Q10 acts in the human LDL as very effective natural antioxidant.

HMG-CoA还原酶抑制剂是非常有效的降脂药物，但它同时抑制胆固醇和辅酶Q的生物合成，而其中辅酶Q是线粒体呼吸链中的中间电子载体，其还原形式在人LDL中是有效的天然抗氧化剂。

The five prosthetic groups (FAD, [2Fe-2S], [4Fe-4S], [3Fe-4S] and heme group) required for electron transfer from succinate to ubiquinone were unambiguously assigned into the electron density map. Besides, we find there are some electron densities around the Qp pocket at the matrix side and we believe it represents the head structure of ubiquinone, which is proved by the inhibitor bound structure that 2-TTFA just locating at the Qp site. At the same time, we find there is the second 2-TTFA binding site, locating the inter-membrane side. This finding will change our knowledge about the electron transfer inside Complex II and the ubiquinone transfer between Complex II and Complex III, and endow a new role of Complex II in electron transfer chain.

除了对各个电子传递体（ FAD ，[2Fe-2S]，[4Fe-4S]，[3Fe-4S]以及血红素分子）进行精确定位外，我们在该结构跨膜区靠近线粒体基质一端的口袋 Qp 中，发现了一些电子密度，认为是所结合的辅酶 Q 的头部结构，这一点被与抑制剂结合的复合体的结构所证明，在该结构中， 2－ TTFA 恰好结合在口袋 Qp 中，同时，我们还发现了第二个2－ TTFA 的结合位点，位于跨膜区靠近线粒体膜间隙一端的口袋 Qd 中，这个发现具有全新的意义，将影响人们对电子在复合物 II 中传递以及辅酶 Q 在复合物 II 与 III 之间转移的认识，促使人们重新复合物 II 在线粒体呼吸链中的角色。

The prestent invention discloses the cDNA sequnce of a new human reduced NADH: ubiquinone oxidoreductase 14 KDa subunit (NADH-CoQ14KDa subunit). The protein coded with the sequence is the homolog of ox's NADH-CoQB14.5b subunit.

本发明提供了一种新的人还原型烟酰胺腺嘌呤二核苷酸－辅酶Q氧化还原酶14千道尔顿亚基（NADH：ubiquinone oxidoreductase 14 kDa subunit，简称为&NADH－CoQ 14 kDa亚基&的cDNA序列，该序列编码的蛋白是牛NADH－CoQB14.5b亚基的同系物。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。