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Objective To observe the effect and side effects of STI571,an tyrosine kinase inhibitor,on BCR/ABL positive leukemia.

目的 ：观察酪氨酸激酶抑制剂STI5 71在BCR/ABL融合基因阳性表达白血病的治疗效果和副作用。

Objective To investigate whether the tyrosine protein kinase Src and Fyn were involved in the neuronal cell death induced by cerebral ischemia followed by reperfusion.

目的 观察胞内可溶性酪氨酸蛋白激酶Src、Fyn蛋白对脑缺血再灌注后海马CA1区神经细胞存活的影响。

Moreover, Fyn kinase directly phosphorylated LKB1 on tyrosine 261 and 365 residues, and mutations of these sites resulted in LKB1 export into the cytoplasm and increased AMPK phosphorylation.

这是&能量主开关&磷酸化腺苷酸活化蛋白激酶在它们脂肪和肌肉组织中含量较少的结果。这些发现显示，这种酶有可能帮助开发一种减肥新药。

Studies in neuropsychopharmacology and molecular neurobiology indicate that neurotransmitters and its receptors play important roles in alcohol abuse and addiction, and post-receptor signal transduction pathways, including cyclic adenosine 3', 5'-monophosphate-protein kinase A, phosphoinositide, Ca(superscript 2+)-calmodulin, phospholipase D and tyrosine kinase Fyn signaling cascade.

神经精神药理学和神经分子生物学研究表明，酒精滥用和成瘾不仅与中枢神经系统的神经递质及其相关的受体有关，而且，受体后的信号转导通路参与了酒精依赖的形成过程。其中包括环磷酸腺苷-蛋白激酶A、磷脂酰肌醇、Ca(上标 2+)-钙调蛋白、磷脂酶D以及酪氨酸激酶Fyn等信号途径。

Objective To investigate whether tyrosine protein kinases Src and Fyn were involved in the phosphorylation of NR2A induced by cerebral ischemia followed by reperfusion. Methods Transient (15 min) brain ischemia was induced by the four-vessel occlusion in Sprague-Dawley rats. The antisense oligodeoxynucleotides of Src and Fyn were used to suppress the expression of Src and Fyn by intracerebroventricular infusion once a day for 3 days before ischemia.

近年来，最受人们关注的缺血性脑损伤机制是兴奋性氨基酸（excitatory amino acid， EAA）的神经毒性作用及神经元内钙超载触发的级联反应［1］，其中NMDA受体的NR2亚基在缺血性脑损伤中起着非常重要的作用，在缺血/再灌注（ischemia/ reperfusion，I/R）过程中其蛋白表达、磷酸化水平均有改变。

Western blot was used to examine the phosphorylation of NR2A in rat hippocampus. Results Both Src and Fyn antisense ODNs could decrease the phosphorylation of NR2A induced by cerebral ischemia/reperfusion, while administration of Src antisense ODNs had more suppressive effect on the phosphorylation of NR2A than Fyn antisense ODNs.

对NR2亚基有磷酸化调节作用的是Src家族酪氨酸蛋白激酶（Src family of protein tyrosine kinase， Src PTKs），这是一类膜结合的非受体酪氨酸蛋白激酶；现已知Src家族成员中Src、Fyn、Yes、Lyn、Lck在中枢神经系统中均有表达。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。