查询词典 tyrosine

Tyrosine protein kinase is one of the key kinases in cell signal transduction,which plays an important role in cell growth,development and functional regulation.

酪氨酸蛋白激酶是细胞信号转导的主要信号酶之一，对细胞的生长、发育与功能调控起着重要的作用。

Objective: To set the measuring method of tyrosine hydroxylase activity in the brain of conscious rats.

中文摘要：目的：建立清醒自由活动大鼠脑内酪氨酸羟化酶活性的测定方法。

AIM: To explore the relationship of methylation status and expression of spleen tyrosine kinase gene in colorectal cancer cell lines.

目的：探讨结直肠癌细胞中脾酪氨酸激酶基因甲基化和表达的关系。

We also analyzed the changes of total levels of protein tyrosine phosphorylation in three tumor cells upon suspension.

我们同时检测了三种乳腺癌细胞在悬浮培养时总体蛋白酪氨酸磷酸化水平的改变。

The chemical shifts and concentrations of the metabolites in the serum were measured in serum samples with pH varied between 7.0 and 7.8. It was demonstrated that, from pH 7.0 to pH 7.8, the chemical shifts of many low molecular-weight metabolites drifted upfield and the intensities of phenylalanine, tyrosine, histidine, and lactate in the T 2-weighted NMR spectra changed significantly.

实验结果表明 pH的改变不仅能够引起血清中一些小分子代谢物化学位移的改变，还会影响小分子代谢物与蛋白的相互作用，引起这些小分子结合态和游离态含量的变化。

On the basis of molecular design, urushiol and tyrosine, with unique chemical structure, were selected as units to fabricate five kinds of stable and functional multilayer films via layer-by-layer self-assembly method.

本论文在对自组装膜的发展历史、自组装技术进行综述的基础上，从分子设计的思想出发，选用具有独特结构和性能的功能分子——漆酚和酪氨酸作为组装基元，以层层自组装技术制备了五种新型的，具有高稳定性的功能多层膜。

RESULTS The SOD activity had linear correlation with pH in the range of pH 2.2-8.0 when SOD concentration was fixed. The varication of activity after ultrosonication had linear correlcation with fluoresent intensity at 340 nm. With increase of uhtrosonic frequency, the microenviroment of tyrosine and tryptophan inside the SOD molecule was changed, then the balance of hydrophokicity and hydrophilicity inside the molecule was broken, this induced the blue shift of synchronous spectrum band and decrease of SOD activity.

结果 SOD浓度一定、pH2.2~8.0时，活性与其线性相关，超声后活性差值与340 nm荧光强度差值的线性相关；随着超声次数的增加，蛋白质SOD分子内部的酪氨酸、色氨酸所处的微环境被扰动，打破了分子内部的疏水和亲水平衡，使蛋白质的活性降低，在荧光检测中观察到普通荧光谱带蓝移，同步荧光的荧光峰位总体呈现峰位蓝移和强度下降。

Started from D-tyrosine, we obtained the tetramic acid 96 using Jouin reaction. The assembly of the second fragment 109 was stared from 1,4-butandiol,using asymmetric alkylation reaction developed by Oppolzer as a key step. Coupling of the tetramic acid 96 with 109 provided the key intermediate 110 according to Yoshii\'s procedure. After remove protective group and Sharpless epoxidation, we obtained the key intermediate 113. Its macrocyclization to form the final product is in progress.

本论文的第二章主要对Macrocidin A开展了合成工作，我们从D构型的酪氨酸出发，经过官能团转换；利用Jouin反应生成Tetramic acid 96，另外一个片断从1，4-丁二醇开始经过多步反应生成碘化物104，利用Oppolzer发展的手性樟脑磺酰胺为辅基参与的不对称烷基化反应，引入手性甲基，生成关键中间体109，接着通过Yoshii发展的方法连接96和109生成110，经过Sharpless不对称环氧化反应建立环氧化合物，然后脱去保护基得到关环前体113，分子内的Mitsunobu反应进行关大环反应正在进行之中。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

Tyrosine was identified by tlc. resultsthe results showed that the cremastra appendiculata makino significantly increased the activity of tyrosinase,but the rhizoma bletillae inhibited .

结果山慈姑的激活作用最高，丽江山慈姑和金果榄作用不明显，白及呈抑制作用；薄层检测显示山慈姑、丽江山慈姑和金果榄中含有酪氨酸。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。