查询词典 tributyrin

Objective To investigate the effect of butyric acid and its derivative tributyrin in combination with all-trans retinoic acid on differentiation induction of APL cells.

目的 研究丁酸类衍生物联合维甲酸对急性早幼粒细胞白血病患者原代培养细胞的诱导分化作用。

Olive oil, tributyrin and p-nitrophenyl palmitate were used as substrates to measure lipase activity.

分别以橄榄油、三丁酸甘油酯和对硝基苯酚棕榈酸酯为底物检测展示的脂肪酶酶活。

Thus, tributyrin may be a potential chemopreventive and chemotherapeutic agent against human gastric cancer.

因此，tributyrin可能是一个非常有应用前景的预防和治疗胃癌的天然化学药物。

These data demonstrated that tributyrin can efficiently inhibit gastric cancer cell growth by inhibiting DNA synthesis and inducing apoptosis. The tributyrin-induced apoptosis is associated with down-regulation of Bcl-2 expression and up-regulation of Bax expression.

这些结果首次显示tributyrin能有效地通过抑制DNA合成和诱导细胞凋亡达到抑制胃癌细胞生长的作用，细胞凋亡与Bcl-2表达量下调和Bax表达量上升有关。

The experimental diet with glutamine (10 g/kg), or with lactitol (3 g/kg), or with tributyrin (5 g/kg), or with lactitol (3 g/kg) plus tributyrin (5 g/kg), the aim is to determined effects of several several substances and compound on early weaned piglets.

整个试验分为以下四个部分： 1 几种物质对早期断奶仔猪生长性能的影响在断奶当天、断奶后7天、14天、21天及28天分别对仔猪进行称重，观测猪只的平均日增重、日采食量、料重比及腹泻率。

The expression of p-p38 and Rho GDIαwas upregulated in LCA by either low shear stress or hypertension. However, the highest expression of p-p38 and Rho GDIαwas observed in LCA of low shear stress accompanied by hypertension.(4) Effect of low shear stress on both decreasing apoptosis and increasing proliferation of VSMCs in LCA was reversed by tributyrin, a HDAC inhibitor.

当高血压伴有低切应力时，两者的协同作用诱导p-Akt的表达水平进一步增加；(3)高血压和低切应力都可以诱导颈总动脉p38和Rho GDIα表达增加；当高血压伴有低切应力时，两者的协同作用诱导颈总动脉p38和Rho GDIα表达进一步增加；(4)HDAC抑制剂Tributyrin可以通过抑制VSMCs增殖，促进VSMCs凋亡，在干预低切应力诱导的血管重建中发挥作用。

To elucidate the possible mechanism of differentiation and /or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor, the level of acetylated histone H3 was detected by Western blot, p21~ WAF1expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin，TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Westernblot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21WAF1表达量的改变。

To elucidate the possible mechanism of differentiation and/or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor , the level of acetylated histone H3 was detected by Western blot, p21(superscript WAF1) expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin， TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Western blot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21(上标 WAF1)表达量的改变。

The results suggested that vascular remodeling was the most prominent in LCA subjected to low shear stress accompanied by hypertension, which is regulated through the changing expression of p-Akt, p-p38, Rho GDIα. Tributyrin could affect the flow mediated carotid remodeling by both increasing apoptosis and decreasing proliferation of VSMCs through PI-3K/Akt, bcl-2, p53, p27. Tributyrin could have potential roles in treatment of vascular diseases, such as artherosclerosis and vascular restenosis, etc.

结果提示，高血压与切应力协同作用对血管重建的影响最为显著，Akt、p38和Rho GDIα信号通路参与了高血压与低切应力诱导的血管重建过程；Tributyrin对血管重建的干预作用是通过影响PI-3K信号通路，调节凋亡相关蛋白bcl-2以及细胞周期调控蛋白p53和p27的表达水平而实现的；Tributyrin有可能成为一种在动脉粥样硬化、血管再狭窄等疾病防治中有潜在临床应用价值的药物。

One integrative transformant was obtained through PCR and phenotype identification, designated as A.oryzae ONL1. The 7-day fermentation broth of A.oryzae ONL1 could hydrolyze tributyrin verified by forming transparent cleared zone on tributyrin plate, and the enzyme activity reached 2.5 U/mL. The SDS-PAGE electrophoretic map of the fermentation broth demonstrated that there was a typical RML band at 32.5 kDa.

其培养7天的培养液上清在以三丁酸甘油酯为底物的平板上形成清晰的水解透明圈，碱滴定法酶活测定表明培养液酶活可达2.5 U/mL，培养液上清的SDS-PAGE图谱在32.5 kDa处有RML的特征条带。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。