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W by hypodermic in each group,the effect and adverse reaction in each group on renal anemia were observed and compared.results the anemia of each group was improved after treatment.hb,hct and tast in venous group significantly increased than those of oral group,while incidence of adverse reaction decreased as compared to oral group.conclusion fe3 dextran that aid for rhuepo is better than oral group (p.01),and incidence of adverse reaction is lower,thus it is a better way that adds chalybeate to hd patients which is short of iron.

w皮下注射。比较两组患者贫血治疗的效果和副作用。结果治疗后两组患者贫血均改善,其中静脉补铁组的hb、hct及tast较口服补铁组显著升高(p.01),而不良反应发生率较口服补铁组降低。结论静脉注射右旋糖酐氢氧化铁可作为血透伴缺铁患者更理想补铁方式,配合rhuepo治疗贫血,疗效明显优于口服补铁,且不良反应发生率低。[关键词]右旋糖酐氢氧化铁;肾性贫血;血液透析

The effect of Jiusuyu on ebriety rate, ebriety time of acute alcoholism mice observed after preventing treatment 80 healthy mice, bisexual and each half, were randomly divided into 4 groups, 20 mice every group, namely model group (equal volume physiological saline were given through the means of watering stomach), low-dose group of Jiusuyu (called low-dose group, 1.62g/100g avoirdupois Jiusuyu drank through the means of watering stomach), high-dose group of Jiusuyu (called high-dose group, 3.24g/100g avoirdupois Jiusuyu drank through the means of watering stomach), and Gehuaji-echeng liquid control group (called control group, 1.31g/100g avoirdupois) Gehuajiecheng liquid were drunk through the mea

酒速愈预防性给药对急性酒精中毒小鼠醉酒时间、醉酒率的影响健康昆明种小鼠,雌雄各半,随机分为4组:模型组、酒速愈低剂量组(灌服酒速愈1.62g生药/100g体重)、酒速愈高剂量组(灌服酒速愈3.24g生药/100g体重)、葛花解酲汤组(灌服葛花解酲汤1.31g生药/100g体重),每组20只。各组小鼠禁食12hs,各治疗组均一次性给药,模型组灌服生理盐水,30mins后均以56°红星二锅头酒灌胃(1.4ml/100g体重)。观察记录小鼠醉酒时间(从清醒到翻正反射消失的时间),小鼠醉酒与否以翻正反射是否消失为标准:小鼠灌酒后将其背向下轻轻放入鼠笼,若小鼠背

Methods: Screens 983 example metabolism syndrome patient from the immortal river area healthy physical examination staff, the blood sugar unusual 675 examples will carry on the grouping, branches out the pure IFG group, the IFG+IGT group and diabetes group through the OGTT experiment (has explicit diabetes medical history not to carry on the OGTT experiment), conducts the intervention research to the pure IFG group 117 examples, divides into the life style intervention group, the life style add two armor biguanide intervention group and the control group, after the research intervention treatment, this part of patient's extension to turn over to the situation.

从仙河地区健康查体职工中筛选出983例代谢综合征患者,将其中血糖异常的675例进行分组,通过OGTT试验分出单纯IFG组、IFG+IGT组和糖尿病组(有明确糖尿病病史者不进行OGTT试验),对单纯IFG组117例进行干预研究,分为生活方式干预组、生活方式加二甲双胍干预组和对照组,研究干预治疗后这部分病人的转归情况。

Objective To examine the value of Edaravone in the treatment of vascular dementia through ethologic and pathologic changes induced by chronic cerebral ischemiaMethods Wistar rats were randomly divided into sham operated group,model group,edaravone group and duxil groupThe chronic cerebral hypoperfusion models were made by permanent bilateral occlusion of both common carotid arteriesThe memory ability and ultramicrostructure of brain tissue were observedResults The escape latencies in model group were more significantly prolonged than that in the other groups (P<005)But there was no significant difference between edaravone and duxil groupAnd pathologic changes observed by electron microscope in nerve cell of edaravone group and duxil group and model group were fairly light than that in sham operated groupEdaravone group had increased mitochondrium and frontal membranous synaptic vesicle and more productive metabolic activityConclusions Edaravone can lessen injures of hippocampal neurons loss to improve the spatial learning and memory abilitiesAnd it is proved further that edaravone can treat VD

目的 观察依达拉奉对慢性缺血致血管性痴呆大鼠行为学及形态学的影响,探讨依达拉奉在治疗VD中的应用价值。方法实验分假手术组、模型组及都可喜对照组及依达拉奉治疗组,应用双侧颈总动脉结扎方法制备慢性脑缺血大鼠痴呆模型,观察各组大鼠的记忆功能及脑组织超微结构改变。结果缺血组水迷宫表现同对照组、都可喜组及依达拉奉组相比有显著差异(P<005),依达拉奉组与都可喜组相比未见显著差异。同时电镜观察结果也发现依达拉奉组及都可喜组与模型组及假手术组相比神经细胞病理改变较轻,且依达拉奉组线粒体及前膜突触小泡增多,代谢活动较都可喜组旺盛。结论依达拉奉可能通过减轻海马神经元的损伤来改善慢性脑缺血大鼠空间学习记忆障碍,证明依达拉奉对慢性缺血致VD大鼠具有治疗作用。

backgroundto study the treatment method for the cecum mobile.case reports143 cases of cecum mobile were classified into 4 groups according to clinical symptoms, diarrhea group(35 cases of group a), alternate between diarrhea and constipation group(38 cases of group b), constipation group(55 cases of group c) and right hypogastric vague pain group(15 cases of group d), and the therapeutic effects were observed after 1 month of the operation.

[背景]探讨移动盲肠的治疗方法。[病例报告]根据临床症状将143例接受手术治疗的移动盲肠患者分为4个组,即以腹泻为主要症状的a组为35例,腹泻及便秘交替为主要症状的b组为38例,便秘为主要症状的c组为55例、以右下腹隐痛为主要症状的d组为15例。

Methods: the present study improved isolation of LDL, undertook one-step of density gradient centrifugation, generate E-LDL by treatment LDL with multiple enzymes, direct fluorescent label CRP and LDL, and investigate whether CRP play as intermedial mediator in atherosclerosis. Experiment consists of 8 groups: control group, N-LDL group, ox-LDL group, E-LDL group, CRP+N-LDL group, CRP+ox-LDL group, CRP+E-LDL group.

本研究参考文献改进LDL提取方法,通过一次性密度梯度超速离心,分离LDL,并且通过复合酶处理以及铜离子氧化法分别生成E-LDL和ox-LDL,并直接对CRP及LDL进行荧光标记,通过与内皮细胞共孵育,利用荧光显微镜检测CRP及LDL与内皮细胞结合,实验分为8组:空白对照组、CRP组、N-LDL组、ox-LDL组、E-LDL组、CRP+N-LDL组、CRP+ox-LDL组、CRP+E-LDL组。

Simulate the condition of temperature and energy control in percutanous MWA for HCC to ablate SMMC-7721 cell strain suspension.There were five experiment groups:A.control group,B.45℃10 min group,C.50℃3min group,D.54℃3min group and E.60℃instant group.Detection for apoptosis was performed at 30 minutes and 2 hours after ablation.2.Thirty-two C57 mice were undertaken hypodermic inoculation of Hepal-6 tumor piece at right groin as ablation tumor and at left groin as observation tumor one week later.The mice with double tumors were separated into four groups:A.control group with no treatment,B.MWA group treated with MWA only,C.mDC group treated with MWA and subcutaneous injection of mature dendritic cells sensitized by neoantigen of Hepal-6 cell strain,D.iDC group treated with MWA and peritumoral injection of immature dendritic cells without neoantigen sensitization.

模拟肝癌微波治疗中常用消融区边缘的温控和能量条件,消融人肝细胞癌株SMMC-7721细胞悬液,分为五组:A、对照组,B、45℃10min组,C、50℃3min组,D、54℃3min组,E、60℃即刻组,消融后30分钟及2小时进行凋亡检测。2.32只C57小鼠左侧腹股沟皮下接种Hepa1-6鼠肝癌细胞瘤块作为消融瘤,间隔1周,右侧腹股沟皮下接种瘤块作为观察瘤,成瘤后分为四组:A组,对照组,不行治疗;B组,微波组,仅微波消融小鼠消融瘤;C组,成熟DC组,微波消融小鼠消融瘤,并于小鼠双侧腋下注射肿瘤抗原致敏的树突状细胞;D组,未成熟DC组,微波消融小鼠消融瘤,并于消融瘤周注射未成熟树突状细胞。

The treatment regimens of Trial patients who were randomized into control group (Trial-control group) were quite the same with the standard treatments of Nontrial group. There was no significant difference in median survival between Trial-control group and Nontrial group. The median survival of Trial group patients who were randomized into trial group was significantly longer than that of Nontrial group patients.

在Phase III的临床试验中,病患会被随机分派到试验组(Trial-trial)或是控制组(Trial-control),控制组的治疗方式与非临床试验组类似,两组存活时间在统计上没有差异;使用新药或新疗程的Trial-trial组的存活时间比非试验组显著较长。2000-2003年间存活时间有较长的趋势,而医疗成本部分则是2004年比起2000年显著的升高。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周,炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节,另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg,20分钟后踝关节照光,激光波长627.sum,功率密度 100mwcm',照射时间1000秒,能量密度100)/。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径,治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后,治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗,随机治疗一侧膝关节,另一侧作自身对照。兔耳静脉注入I'arrainrelomg/Kg,20分钟后,膝关节用金蒸气激光照射,激光能量密度100)儿旷。24 /J'时后取膝关节滑膜作病理检查,并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果: 1。模型观察:CIA大鼠炎症高峰期滑膜下炎细胞浸润明显,滑膜细胞明显增殖,炎症达到高峰后二周,血管缀形成,并侵蚀和破坏软骨和骨, CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生,滑膜下炎细胞浸润,也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明,各组织对HMME 的吸收速度和吸收量不同,荧光值一时间曲线不同,滑膜组织比皮肤和软骨对 HMME的吸收多,在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明:PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性,但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好,统计学检验差异有显著性。。3_军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少,图像分析结果表明面密度(阳性染色的面积总和与统计视野面积的比值)治疗组小于对照组,统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多,图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组,统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小,与对照组相比,统计学检验差异有显著性。结论:二。CIA、AIA的病理改变类似人类RA,可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同,滑膜组织比皮。

Clinical study: 90 patients diagnosed in The Third Hospital of Beijing University according as diagnostic standards were divided into three groups stochastically:therapy group, control group I and control group II, each group has 30 patients, the therapy group was treated by the method of clarifying and descending the lungs and the stomach, the anti-cough decoction; the control group I was given acute bronchitis syrup and Jiawei Baohe pills; the control group II only given acute bronchitis syrup, after seven days treatment, the results show that the efficiency of the therapy group is 80%, that is higher than both of the control groups(p.01), the therapeutic principle and formula is effective and valued in clinic.

临床研究部分:以2001年9月-2002年3月在北京大学第三医院中医科门诊就诊的90例有胃内伤基础的外感咳嗽患者作为观察对象,随机分为3组,治疗组治以肃肺降胃法,用自拟汤药治疗;对照组I治以急支糖浆合加味保和丸;对照组II单纯用急支糖浆,并详细记录患者临床症状和体征的变化,经一个疗程(7天)的治疗,治疗组取得了80%的显效治愈率,显著优于对照组(P.01),说明这种立法与处方是可行的,具有较高的临床价值,并进一步拓宽了治疗外感咳嗽的思路与方法。

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Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

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