查询词典 translocates

Moreover, Par-3 localizes on the membrane when Caco2 or MDCK cells are confluent, but translocates to the nucleus when cells are subconfluent.

此外，Par-3蛋白在Caco2和MDCK细胞高密度时主要定位于细胞膜上，在低密度时主要定位于细胞核中。

However, a steady input of evidence for the transcription-independent function of p53 in apoptosis has been accumulating recently. Although a detailed mechanism has not yet been determined, recent data have revealed that upon an apoptotic stimulus, p53 translocates into mitochondria to interact directly with Bcl-2 or Bcl-xL to displace and activate proapoptotic Bax signaling.

但是，还有研究证明p53也通过转录非依赖的形式来调节细胞凋亡，尽管这个作用的机制还没有被详细的阐明，但是最近的研究报道说明了，p53可以直接转移定位到线粒体上，与Bcl-2或者Bcl-xl结合后，从而使Bax游离下来并活化。

Ormone binding and dissociation of Hsp90, p23 and the immunophilin changes the conformation of the receptor, which then translocates to the nucleus and activates tranion.

sp40， Hsp70 and Hop解离与随后的23 (23)和亲免蛋白的结合完成了受体前体复合体的成熟过程。

From the present study, it has been demonstrated that CD44 is cleaved subsequently by MT1-MMP and Presenilins in PC-3 Cells, and in turn causes the release of the CD44ICD. CD44ICD translocates into nuclear and may regulate the tumor cells malignant phenotype via NF-κB pathway which plays a critical role in the malignant progression of prostate cancer, interruption of this pathway might contribute to the inhibition of tumor growth and invasion.

本研究表明：在PC-3细胞中CD44分子分别受MT1-MMP和Presenilin1/2的作用，最终导致CD44ICD从膜结合型CD44ΔE的水解释放并转移进核，并可能通过调控NF-κB等转录因子，影响肿瘤细胞的恶性表型。

Stabilized, hypophosphorylated β-catenin translocates to the nucleus, where it interacts with transcription factors of the TCF/LEF-1 family, leading to the increased expression of genes, such as c-myc and cyclin D1

那么，药物的作用有以下几个可能性：2。药物促进或抑制catenin的核转位，但不影响其磷酸化程度3。药物可直接磷酸化catenin或直接使其去磷酸化，即具有磷酸激酶或磷酸酶的作用。

It is essential for the activation of NADPH oxidase that p47〓, a cytosolic component of NADPH oxidase, is phosphorylated by PKC and translocates to the plasma membrane to form an active complex with other cytosolic components and the membrane oxidase subunits.

在PKC激活的同时，磷脂酰肌醇3-激酶（PI3-K）也被激活，PI3-K进一步引起蛋白激酶B激活，据研究认为Akt能够激活NADPH氧化酶，而且PI3-K还能够参与中性粒细胞的趋化作用。

Recently, it is found that the neuron apoptosis caused by brain ischemia is associated with signal pathway of endoplasmic reticulum stress, which is different from the traditional apoptotic pathway. Caspase-12 has been identified as a molecule which initiates apoptosis selectively in response to ER stress and is not activated by other pathways. Caspase-12 is localized on the ER membrane, but once specifically activated by ER stress, it translocates to the cytoplasm.

最近的研究发现，这种细胞凋亡与内质网应激(endoplasmic reticulum stress ER stress)有关，其是一种不同于经典的凋亡途径的新途径，分子伴侣葡萄糖调节蛋白78(glucose regulated protein， GRP78/Bip)表达增高是反应ER stress的最敏感的指标，胱冬酶-12(caspase-12)为鼠源性的内质网膜上的蛋白，它的特点是只被内质网诱导的凋亡所激活而不被其它非内质网因素所激活。

In response to fear conditioning,β-arrestin-2 translocates to amygdalar membrane where it interacts with PDE-4, a cAMP-degrading enzyme, to inhibit PKA activation.

arrestin-2与β-arrestin-1一样，广泛存在于各种细胞中，调节绝大多数G蛋白偶联受体的活性研究显示，大脑在应对恐怖信息的时候，β-arrestin-2能转移至杏仁核细胞膜，与PDE-4——一种cAMP降解酶相互作用，抑制PKA活性

In response to extracellular stimuli, ERK1/2 translocates to nucleus, phosphorylates transcription factors,such as Elk1,ATF2,Sap-1α,c-myc,STAT, and so on, co-regulators and chromatin proteins to initiate transcriptional changes.

斑点杂交研究发现Ngb mRNA在大脑皮层、海马和丘脑等部位表达，缺血缺氧可使Ngb mRNA表达上调，其表达上调程度与相应区域对缺血缺氧的耐受性呈正相关。

In heathlty cells, AIF protein is normally confined to mitochondrial intermembrane space. However, after apoptosis is induced, AIF protein can be released from mitochondria and translocates into nucleus leading by its nuclear localization signal.

正常情况下，AIF蛋白定位于细胞线粒体膜间隙，当有凋亡信号刺激时，AIF分子从线粒体释放到细胞浆，再通过其核定位信号转位到细胞核中，直接引起染色体凝集和DNA的大片段(~50kb)断裂，导致细胞凋亡。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。