查询词典 transcriptional

In the context of these new forms of treatment, epigenetic or transcriptional cancer therapy is clearly promising.

这篇文章主要论述这些治疗的新形式，表观遗传或者转录的癌症治疗是很有希望的。

Here, we provide evidence that human BAMBI, like its Xenopus homolog, inhibits the transcriptional response of TGF-βsignaling, suggesting an evolutionally conserved activity of BAMBI.

我们的研究表明，人类BAMBI基因和爪蟾一样，也能作为TGF-β家族的通用抑制因子，说明BAMBI的功能在进化过程中高度保守。

Objective: To clone the 5' flanking region of the human CD34 gene containing transcriptional regulatory sequence.

目的：克隆有特异调控活性的人CD34基因5'端转录调控序列。

Our result showed that P450scc expression was observed in hippocampus, habenular nucleus, neuron nucleus of thalamus and hypothalamus, and cerebral neocortex. The colocalization of P450scc and NeuN demonstrated that most of P450scc exist in neuron cell in these regions. In order to clarify the transcriptional regulation of CYP11A1 gene, established the transient SCC-iCre transgenic mice model by using R26R system to study the promoter activity of human CYP11A1 gene in the brain.

为了证明内生性P450scc在这些脑区的表现，本研究利用免疫组织染色分析，说明了在小鼠海马回结构，间脑内的上视丘疆核、视丘神经核、下视丘神经核，与新皮质等区域中皆可侦测到，且主要表现在神经细胞。

The term"homeodomain"has evolved to define a class of protein domains that has recognizable similarity to a 60 amino acid motif (encoded by 180 bp homeobox sequences) originally recognized in three Drosophila homeotic and segmentation proteins. The homeodomains that have been tested contain sequence-specific DNA binding activities and are part of larger proteins that function as transcriptional regulators.

其中一类转录因子通过同源域结合特定的DNA序列，这种特殊的转录因子都包含一个同源盒，它有180bp序列可以编码DNA结合同源域，称同源盒基因（Homeobox gene，Hox gene），带有同源框的基因经过转录产生带有同源域的蛋白质。

The result was also confirmed by measuring the transcriptional levels of four hordein homologous genes in thebarley cells. Free proline participates in the synthesis of B3-Hordein, which plays a key rolein regulating the balance of the cellular proline.

而大麦(PC1163)细胞醇溶蛋白4个同源基因的转录水平的检测结果也证实了这一点，游离脯氨酸参与合成B3-Hordein，在降低细胞内脯氨酸含量并维持脯氨酸动态平衡方面起了重要作用。

It encodes a putative zinc finger transcription factor, and is a transcriptional corepressor for thyroid hormone receptors. Hairless gene plays a critical role in maintaining the delicate balance between cell proliferation, differentiation, and apoptosis in the hair follicle as well as in the interfollicular epidermis, and is concerned with the control of hair growth cycling.

无毛基因是与皮肤和被毛结构有重要关联的核受体基因，编码一个锌指结构转录因子，是甲状腺激素受体的转录辅阻遏物，并参与毛发生长周期的调控，在维持毛囊及毛囊间上皮的增殖、分化、调亡的精致平衡中扮演重要角色。

Through PCR and sequencing, a fragement sequence with lamin gene feature was obtained. It was of of transcriptional activity. In addition, we also cloned and identified giardial DNA topoisomerase gene.Our phylogenetic analysis showed that although Giardia diverged early but not first, thus, it is not as primitive as thought before.

然后进行了核纤层蛋白基因的扩增和鉴定，获得了一个具有明显核纤层蛋白基因特征的基因序列片段，并证明它是表达的且不具内含子；此外还克隆鉴定了作为核骨架重要成分的DNA拓扑异构酶II的基因；在此基础上结合已报导的不同进化地位生物上的数据进行了分子系统学分析，结果显示贾第虫虽然分支较早，但不象过去所认为的那么原始。

The results showed that TNF-α effectively inhibited preadipocyte proliferation stimulated by insulin and decreased lipogenesis through inhibiting stimulation of insulin on transcriptional expressions of lipogenic genes such as acetyl-CoA carboxylase α(ACC1), fatty acid synthase, sterol regulatory element binding protein-1c in adipocytes, suggesting that TNF-α is a effective inhibitor of adipogenesis in adipose tissue.

结果表明，TNF-α可有效抑制胰岛素对原代培养大鼠前体脂肪细胞增殖的促进作用，并通过抑制胰岛素对转录因子SREBP-1c和脂肪酸合酶FAS及ACC1基因转录表达的促进作用，减少脂肪酸的生物合成，抑制成熟脂肪细胞的脂肪生成，证明TNF-α是动物脂肪形成的有效抑制因子。

Permissive cells allow the transcription and translation of the transcriptional activator protein, which activates the early genes of the virus and the lytic cycle.

容纳性细胞允许转录活化蛋白的转录和翻译，其激活病毒的早期基因和溶解性周期。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。