查询词典 transcriptional

Five pairs of primers were designed for PCR according to five fragments of the putative virulent genes acquired by suppression subtractive hybridization between virulent strain HA9801 and avirulent strain 12 of Streptococcus suis type 2 （ SS2 ）. The five fragments were transcriptional regulator (15# and 154# fragments), amino acid permease (210# fragments), ABC transporter (9# fragments) and surface anchored protein (187# fragments).

通过猪链球菌 2 型（ Streptococcus suis type 2， SS2 ）毒力菌株 HA9801 与无毒力菌株 12#之间的抑制性差减杂交实验，获得了可能与 SS2 菌株毒力相关的 5 个基因片段，分别是转录调节子（ 15#，和 154#片段），氨基酸通透酶（ 210#片段）， ABC 转运子（ 9#片段）及表面锚定蛋白（ 187#片段）。

In the perspective of transcriptional control, nod genes exist as a whole NodD regulon, which includes multiple NodD operons.

整个结瘤基因群主要是以NodD调控元的形式存在，分为多个操纵元。

The results showed that Phytophthora sojae on the cellophane carrot agar could not produce oospores within 10 days, no medium were attached when Phytophthora sojae was taken away from cellophane, high-quality RNA, which could meet the requirement of differential display reverse transcriptional PCR was obtained, indicating that it was a suitable cultivation method for Phytophthora sojae to produce pure vegetative mycelia.

结果表明，玻璃纸胡萝卜琼脂培养的大豆疫霉菌，10 d内不会产生卵孢子，当大豆疫霉菌从玻璃纸上取下时，不会带有培养基，能够提取出高质量的RNA，满足差异显示反转录PCR对RNA质量的要求，是一种适合大豆疫霉菌纯营养菌丝的培养方法。

It is possile to induce re-expression of a hypermethylated and silenced tumor suppressor gene by intervening in the DNA methylation and in histone deacetylation. It is worthful to deepen the study on the area of"transcriptional path"for prevention and cure of leukemia.

干扰DNA甲基化和组蛋白去乙酰化，以恢复抑癌基因的重新表达是可能的，通过这种&转录途径&防治白血病是值得深入探讨的研究领域。

The dose-dependent experiment revealed that Id1 antagonised E47 and Ets1 mediated transcriptional activation in a dose-dependent manner. With pGL3-870 as a template, site-directed mutagenesis of E-box and / or ETS-binding site was introduced into p16 promoter. E47 could not activate the transcription of p16 promoter with E-boxes mutated, and Ets1 could not activate the transcription of p16 promoter with EBS mutated. The synergy effect between E47 and Ets1 would occur only if the E-boxes and EBS were present. These facts demonstrated that E47 and Ets1 proteins were not recruited to the promoter by binding to other cis-elements or through interaction with other protein factors, however, they bound to DNA directly through respective consensus sequences in p16 promoter.

以pGL3-870为模板，构建了E-box或/和EBS点突变的p16启动子报告基因载体，将野生型和突变型的报告载体分别与pI-E47、pI-Etsl以及pI-E47+pI-Ets1共转染，发现E47和Ets1所诱导的转录激活作用依赖于启动子DNA上存在的各自的特异结合序列，二者的协同作用也只有当两个结合位点都存在时才会发生，说明E47和Ets1不是与其它作用元件或其它蛋白质因子相作用而被招募到该启动子的，它们是通过启动子上各自的特异结合位点与DNA直接结合的。

Hes5 gene, a key downstream mediators of Notch signaling that functions by inhibiting the expression or activity of positively acting bHLH factors, is a member of bHLH transcription factor family which acts as a positive-negative transcriptional regulators which is expressed transiently in different stages in cells growth and differentiation and orchestrate those precisely timed and progressive maturational events underlying cell fate decisions according to orders of time and spatial and coordinated the function of majority of signaling transduction on target genes to influence the proliferation and differentiation.

Hes5是Notch通路转导途径的一个关键的下游信号分子，通过抑制正调控bHLH因子的表达和活性来发挥作用，隶属于碱性螺旋-环区-螺旋转录因子家族。该家族形成一个正负转录调节器，按时空顺序短暂表达于细胞发育分化的不同阶段，介导和协调多种信号系统对大量靶基因的作用，影响细胞增殖、分化。

Detecting overrepresented known transcription factor binding motifs in a set of promoter sequences of co-regulated genes has become an important approach to deciphering transcriptional regulatory mechanisms.

在一组共调控基因的启动子序列中检测过代表的已知转录因子结合motifs已经成为破译转录调控机制的重要方式。

Notably, all three risk variants map to genes involved in transcriptional regulation and differentiation of B-cell progenitors.

值得注意的是，这三个危险变异基因均涉及到B淋巴细胞祖细胞的转录调控和分化。

As we have knowen that,DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of gastrointestinal tumor.

随着对DNA甲基化的分子机制的进一步认识，以甲基化为基础的标志在临床的应用，尤其是肿瘤的防治，展现了广阔的前景。

DNA CpG island methylation can result in the transcriptional inactivation of tumor suppressors genes, which facilitate tumor progression.

CpG岛甲基化可导致基因启动子的功能异常，引发基因转录的静息，最终导致功能蛋白的下调和缺失，从而促进肿瘤的发生和发展。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐