查询词典 transcriptional

Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现，过量表达HmgD引起果蝇幼虫体内血细胞增生，并出现黑色素瘤，为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制，本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA，首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE，Spn27A在突变体中的转录发生变化，结果发现，Spn27A在三龄中期的表达量低于野生型，而PPAE的表达高于野生型，表明过量表达HmgD影响了酚氧化酶级联反应途径，低水平的Spn27A不足以抑制PPAE的活性，活化的PPAE催化了PPO的活性，使其转变成有活性的PO，从而促进黑色素的生成，使果蝇体内产生黑色素瘤。

In recent studies, the mutations in BMPR-Ⅱand/or misexpression of this gene were found in primary pulmonary hypertension, as well as in a number of cancers. However, the transcriptional regulation of this gene was still unclear.

近年来更是发现BMPR-Ⅱ基因突变或表达异常与家族原发性肺动脉高血压和多种肿瘤的发生和转移有关，然而有关BMPR-Ⅱ基因表达的调控目前所知甚少。

The interaction between Mdfic and Rhox5 protein implied that they may form into complex for transcriptional control and then regulate the determination and differentiation during myogenesis.

Rhox5与Mdfic间的相互作用暗示了两者可能组成转录调控复合体在肌细胞发生和分化中发挥重要作用。

Key words〕 neoplasma;rDNA transcriptional activity;CD＋4;lymph cell;image analysis

关键词〕癌症；图像分析；Th(CD+4)；淋巴细胞；rDNA转录活性；核仁银染强度

Luciferase assay and CREB knock-down experiments further demonstrate that CREB is involved in the transcriptional upregulation of Noxa.

有意思的是，Mcl-1的蛋白水平也可以通过P13K／Akt信号通路而被CPT上调。

On these basis, databases related to transcriptional regulation and the information library of the network of gene regulation will be established, which may greatly promote the study on the function of genome, gene therapy and elucidation of the mechanism of ontogenesis, cell differentiation and the development of tumor and cardiovascular diseases.

在此基础上，开发相应的DNA分析软件，建立与基因表达调节相关的数据库，构建基因表达调节的网络体系，对基因组功能的研究，对细胞分化、个体发生、肿瘤和心脑血管疾病发病等机制的研究以及对基因治疗的研究无疑具有重要的意义。

Based on the above technologies, databases related to transcriptional regulation and the information library of the network of gene regulation will be established, which may greatly promote the study on the function of genome, gene therapy and elucidation of the mechanism of ontogenesis, cell differentiation and the development of tumor and cardiovascular diseases.

在此基础上，可建立与基因转录调节相关的数据库，这对基因组功能的研究，对细胞分化、个体发生、肿瘤和心脑血管疾病发病等机制的研究以及对基因治疗的研究都会具有重要的意义。

Polymorpha cells in low level and produced a 1. 5kb transcript. Transcription of the gene was slightly repressed by exogenous △9 UFA. The FAR element in S. cerevisiae OLE1 promoter described by Choi et al. might not be crucial for positive transcriptional regulation of H-OLE1 gene.

Northern杂交发现，H-OLE1基因在细胞中以较低水平表达，产生1.5kb的转录子；基因表达略受不饱和脂肪酸的抑制；在多形汉逊氏酵母H-OLE1基因的转录调节中，Choi等在酿酒酵母OLE1基因中发现的脂肪酸调节元件FAR可能不是关键的。

The results showed that: 1 under the hydroponic culture established in this research, the experimental wheat plants grew well andperformed the typical architecture responses when exposed in Pi deprivation. Hemi-qantitative RT-PCR revealed that the transcriptional level of known P response gene changed dramatically; 2 In general the length of wheat root axis and the root/ shoot ratio arose when the Pi supply was deprived, however, the change models differed among different wheat genotypes. The investigation on their molecular basis would offer the useful clue for seeking high phosphorus efficiency protoplasma and gene resources of wheat.

结果表明：1在研究建立的小麦水培体系中，小麦植株生长正常并对磷饥饿胁迫条件做出发育形态建成水平的反应；半定量RT-PCR分析显示在此体系中小麦磷响应基因也在转录水平上产生显著变化；2在水培条件下不同基因型小麦对磷饥饿胁迫的反应总体上表现在根轴长度和根冠比有所提高，但不同基因型小麦的反应特点有差异；对这些反应特征的分子机理的深入分析可为有效筛选磷高效小麦新种质以及发掘磷高效基因资源提供线索。

These results suggest that ZNF394 may be a transcriptional represser in Mitogen-activated protein kinase signal transduction pathways and may play important roles in cardiac development and/or cardiac function.

结果表明新基因ZNF394可能是MAPK信号转导途径的一个转录抑制子，并对人类的心脏发育可能具有重要的调控作用

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐