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The form of the narrative, much of which is a straight transcription of the interview tapes, together with the wry commentary of the now-mature and very gifted Lipsky, is original, and intoxicatingly intimate.

形式的叙述，其中大部分是在采访磁带转录直，再加上诙谐的评论现在已经成熟，非常有天赋利普斯基，为正本，并intoxicatingly亲密。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

The Pin1 PPIase domain has shown to specifically isomerize pSer/Thr-Pro peptide bond in a defined subset of phosphoproteins including transcription factors and cell cycle regulator.

Pin1 於是被认为在磷酸化蛋白质之后修饰机制中，扮演著枢角色去调控细胞生反应及正常细胞的细胞分。

It may means that Iridoids composition of Valeriana jatamansi Jones doesn\'t regulate the TPH1 transcription expression.3.4 Effection of Iridoids composition of Valeriana jatamansi Jones on SP and VIP of IBS rats induced by chronic stressMethods:Animals were randomly divided into7 groups:normal group,model group, OSD group,FXT group and Iridoids composition of Valeriana jatamansi Jones groups in quantiy of 24.92mg/kg,12.46mg/kg,6.23mg/kg.

造模后，中枢5-HT呈现降低趋势，这可能是导致动物出现活动能力下降和兴趣缺失的原因之一，蜘蛛香环烯醚萜可以增加下丘脑、海马和杏仁核中5-HT含量，推断蜘蛛香环烯醚萜可通过干预中枢的5-HT通路来改善IBS精神症状。3.2蜘蛛香环烯醚萜对胃肠激素的影响目的：探讨蜘蛛香环烯醚萜对慢性应激所致IBS大鼠SP和VIP的影响方法：动物随机分为对照组、模型组、昂丹司琼组、氟西汀组、蜘蛛香环烯醚萜24.92mg/kg、12.46mg/kg、6.23mg/kg组。

Results: Kaempferol activated PXR-mediated transcription of CYP3A4 in a dose, time-dependent manner.

结果：山奈酚能通过活化PXR诱导CYP3A4的转录表达，其诱导能力随山奈酚的浓度增大和处理时间延长而呈增强趋势。

Leuk Res, 2004,28 Suppl 1:S11 20.9Kim DK, Lee YM. Requirement of c jun transcription factor on the mouse mast cell protease 6 expression in the mast cells.

本研究应用Fluo 4 AM对细胞内钙进行染色后，在激光共聚焦显微镜下动态观察了ICC内Ca2+变化。

OBJECTIVE:To explore the pathogenesis of IR , we established a rat model of insulin resistance by feeding high-fat diet for 8 weeks and measured serum insulin, leptin, tumor necrosis factor- a concentrations and the expression of the lipogenic transcription factor, sterol regulatory element binding protein-Ic in liver of rats.

目的： 建立胰岛素抵抗的动物模型，进行胰岛素、瘦素、肿瘤坏死因子-α和固醇调控元件结合蛋白-1c等相关激素、基因的测定与分析，探讨IR的发生机制；对产生IR的动物进行药物干预，筛选出有效的中药制剂；进一步比较治疗前后相关激素、基因的变化情况，揭示干预治疗的作用机理。

To study the transcription expression law of Musclin gene and Lipogenic gene in muscle of the cadmium poisoning mice regulated by Vc. The experiment adopted RT-PCR detection method to study the variety of expression level of mice Musclin gene and Lipogenic gene (FAS, PPARγ, TGH).

为探讨维生素C调控Cd中毒小鼠骨骼肌中Musclin基因及生脂基因的转录表达规律，用RT-PCR方法研究小鼠Musclin基因及生脂基因(FAS、PPARγ、TGH)表达水平的变化。

Thyroid hormone responsive spot 14, expressed in lipogenic tissues, is suggested as a transcription factor to regulate gene expression of rate-limiting enzymes in lipogenesis. Two THRSP isoforms, THRSPα and THRSP β, were detected at cDNA levels in chickens and ducks.

甲状腺激素应答Spot 14 (Thyroid hormone responsive spot14， THRSP)是一个参与多种脂肪合成限速酶基因表达的转录调控因子，在动物肝脏、乳腺和脂肪组织中高度表达。

High-fat feeding of both strains led to decreased serum triglycerides, hepatic steatosis, and hypercholesterolemia; howeer, B6 mice deeloped worse steatosis and a larger increase in LDL cholesterol. Both B6 background and high-fat feeding increased sterol regulatory element-binding protein-1c (SREBP-1c), a key regulator of lipogenic gene transcription, and its downstream targets.

两种品系的高脂喂养都导致血清甘油三酯降低，脂肪肝，和高胆固醇血症；然而，B6小鼠产生更严重的脂肪肝和低密度脂蛋白胆固醇的增加。B6遗传背景和高脂喂养都增加甾醇调解元件结合蛋白-1c（SREBP-1c），它是脂肪生成基因转录和它的下游靶点的关键调解元件。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。