查询词典 toxicological

To clarify the acetylcholinesterase changes among different developmental stages of Tribolium castaneum, the toxicological and biochemical characterizations of AChE in 10-d larvae, 20-d larvae, pupae and adults were investigated, respectively with the microplate reader method.

为了阐明赤拟谷盗体内乙酰胆碱酯酶在其各虫态间的变化关系，以期为该虫的综合治理提供一定的理论依据，本试验采用微量滴度酶标板法，分别对其10d龄和20d龄幼虫、蛹及成虫体内AChE的生化及毒理学特性进行了较为系统的研究。

Objective To provide toxicological evidence for clinical use of Compound Wikstroemia indica Root Liquid (abbreviated as Wikstroemia Liquid) by examining the toxicity reaction of mice after receiving medicine for a long time.

目的 观察复方鬼辣椒根口服液对小鼠长时间给药可能产生的毒性反应，为临床应用提供毒理学依据。

Toxicological tests showed it was low toxicity, non irritating, slightly sensitisation and negative mutagenicity.

毒理学评价结果显示，该药剂为低毒、无刺激、弱致敏和致突变阴性。

There were 15 pediatric ALL patients, which had received 50 times of chemotherapy with HD-MTX. The records about blood concentration of MTX and clinical conditions for 50 times chemotherapy were divided into two groups. Group I: contained 25 records of stand-risk patients, administering MTX 3.0g/m2; Group II: contained 25 records of mid and high-risk patients, administering 5.0g/m2. Continuous intravenous dripped MTX for 24th in both two groups, while implemented hydrating and alkalizing for 4 days. All patients were rescued 6 times through leucovorin, 15mg/m~2, since 12th after the end of MTX dripping. Then examined the blood concentration of MTX by fluorescence polarization immunoassay approach at 24h, 44h, 68h, at the same time inspected liver function, blood routine examination, the occurrence time and degree of toxicological reactions.

观察15例ALL住院患儿，接受大剂量MTX共50例次，按ALL危险度分2组，低危治疗组接受MTX剂量为3.0g/m2为I组；中高危治疗组接受MTX剂量为5.0g/m2为II组，连续静脉点滴MTX共24小时，同时给予水化碱化治疗，共4天，全部病例均在MTX滴注结束后12小时开始静脉推注四氢叶酸钙(leucovorin，LV)解救，15mg/m2/次，共6次，采用免疫偏振荧光法检测药物滴注24、44、68小时MTX血药浓度，同时检测两组病例的肝功、血常规，观察临床出现MTX毒副反应的时间及程度，观察每个病例毒副反应出现程度与MTX血药浓度关系，两组毒副反应程度比较，进行统计学分析。

The injured gill cells had a different ultrastructure, with endoplasmic reticulum dilated and vesiculated, mitochondrial cristaes partially disintegrated, gill fibre cuticles denatured and dropped. The ultrastructural damages to hepatopancreatic cells were characterized by the decrease of microvilli, swelling and breaking up of mitochondria, expansion of endoplasmic reticulum, disruption and vacuolization of nucleus, tumefaction of nuclear membrane and increase of lipid droplets. As for the toxicological changes of myocardial cells, the mitochondria were swelling, having a lot of vacuolus and disintegrating, while the myofibrils were irregular with endoplasmic reticulum dissolved.

鳃细胞的损害表现为鳃丝水肿，细胞器溶解，角质层变薄，线粒体、内质网的肿胀、解体；肝胰脏细胞的主要损害特征为肝管微绒毛减少，线粒体水肿解体，内质网扩张，细胞核空泡化，核膜水肿和脂肪滴增加；心脏细胞的毒理变化为线粒体内嵴肿胀、瓦解，肌原纤维不规则，内质网溶解。

A toxicological evaluation technique for determinating the toxicity of water soluble and water insoluble chemicals for eucaryotic organism was developed in this dissertation.

首次建立了一种适合测定水溶性及非水溶性化合物对真菌毒性的测定方法，这种方法测定准确，而且操作简便、所需仪器和样品少，适合于推广。

This research used Hepato-pancreas of Ctenopharyngodon idellus as experimental material to study toxicological effect of olaquindox on liver cell and pancreas exocrine cell of Ctenopharyngodon idellus, using the method of histochemisiry, primary cell culture, and immunocytochemistry, and the cells were observed by TEM and LSCM.

本研究以草鱼肝胰脏(Hepato-pancreas)为试验材料，通过原代细胞培养，组织化学，免疫荧光细胞化学等实验方法，运用透射电子显微镜，激光共聚焦扫描显微镜等手段，观察三种不同浓度的喹乙醇对体外原代培养的草鱼肝细胞和胰腺外分泌部细胞的毒理影响。

BACKGROUND ＆ AIM: To study the inhibition of lycopene on the genetic damage induced by mutagens MATERIAL AND METHODS : In accordance with the " Procedures and Methods for Toxicological Assessment on Food Safety ", and the modified micronucleus test and Ames test were used.

背景与目的：研究番茄红素对突变剂诱导的遗传损伤的抑制作用。

Toxicological studies have indicated that OA is a teratogenic, mutagenic and carcinogenic mycotoxin and is strong toxic effect on kidney and liver.

在目前已知的真菌毒素家族中，根据其重要性及危害性排序，OA被认为是仅次于黄曲霉毒素而列于第二位。

The journal publishes original research on the evaluation and characterization of teratogens, carcinogens, or mutagens; reports describing the development of novel experimental techniques for toxicological assessment, or the application of current methods in molecular and cellular biology (including in vitro studies, organ and cell culture, and the use of transgenic animals); as well as critical reviews focused on topics of significant interest to specialists in teratology, cancer biology, and mutation research.

杂志刊有关载致畸剂，致癌物质和诱变剂的评估和特征方面的原始研究；描述毒物评定的实验新技术，或当前方法在分子和细胞生物学（包括体外研究，器官和细胞培养，和转基因动物）中应用的报告；以及对畸形学，癌生物学，和突变研究中生物学家非常感兴趣课题的评论。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。