查询词典 toxic

To any nonchemist, that sounds intimidating, scary, perhaps even toxic -- like something you might pour into a clogged sink to burn through the gunk that's clogging the pipes.

对于任何一位非专业药剂师来说，这个名字听起来都会让人觉得害怕、毛骨悚然，甚至还会觉得有毒──它就像是为了疏通堵在水管里的脏东西而被泼入下水道的物质。

This course mainly includes the basictheories of Drug Toxicology, the toxic effects of drugs and their assessing methods, as well as the application of Drug Toxicology in the nonclinical drug safety evaluation.

本门课程主要包括药物毒理学基础理论，药物的各种毒性作用和评价方法，以及药物非临床安全性评价的毒理学研究内容。

This mitigating cost-benefit factor was not included among those to be considered in formulating BAT limitations for toxic and nonconventional pollutants.

在对有毒和非常规污染物限制中，在提出经济方面可行的最佳技术的诸多因素时，并没有考虑缓和成本一利益之间关系这一因素。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Handling and storage of these highly toxic nonpharmaceutical materials should be separate from APIs.

这类剧毒非药用物质的处理和储存都应当与原料药分开。

Handling and storage of these highly toxic nonpharmaceutical

这类剧毒非药用物质的处理和储存都应当与原料药分开。

43 Any production activities (including weighing, milling, or packaging) of highly toxic nonpharmaceutical materials, such as herbicides and pesticides, should not be conducted using the buildings and/or equipment being used for the production of APIs.

4.43 剧毒的非药用物质，如除草剂，杀虫剂的任何生产活动都不应当使用生产原料药所使用的厂房和/或设备。

43 Any production activities (including weighing, milling, or packaging) of highly toxic nonpharmaceutical materials, such as herbicides and pesticides, should not be conducted using the buildings and/or equipment being used for the production of APIs.

4.6 排污和垃圾 4.60 进入和流出厂房及邻近区域的污水，垃圾和其它废物(如生产中的固态，液态或气态的副产物)应当安全，，及时，卫生的处理。

Toxic effects of 1,2,4-trichlorobenzene (1,2,4-TCB) on Scenedesmus obliquus were studied through investigating the growth, the content of protein and the content of chlorophyll.

以1，2，4-三氯苯(1，2，4-TCB)处理后斜生栅藻的生长状况、蛋白质含量、叶绿素含量、超氧化物歧化酶和过氧化物酶活性、丙二醛含量和培养液总有机碳含量的改变来检测1，2，4-TCB对斜生珊藻的毒性效应及其毒性作用机制。

PEG-PLA block copolymers were synthesized using polyethylene glycol and lac-tide in the presence of low toxic stannous octoate. The copolymer structure was determined by 13C NMR and the average block leng this were calculated.

本文报道聚乙二醇在辛酸亚锡存在下与丙交酯反应合成PEG-PLA嵌段共聚物，用~(13)C NMR测定了共聚物的结构，估算了平均链段长度。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。