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Since these acts are not merely opposed to law but are also in the highest degree insulting and contrary to ecclesiastical liberty, we therefore, in order that we may be able to give an honest account to God of the office entrusted to us, earnestly urge in the Lord, by fatherly sentiments and counsels, the emperor, kings, princes, dukes, marquises, counts, barons, and others of whatever other nobility, pre-eminence, sovereignty, power, excellence or dignity they may be, and we command them by virtue of holy obedience, to observe the foregoing constitutions and to make them inviolably observed by their subjects, notwithstanding any customs whatever to the contrary, if they wish to avoid the divine displeasure and the fitting reaction of the apostolic see.

由於这些行为不仅是反对法律，但也最大程度的侮辱和违背宗教的自由，因此，我们，以便我们可以给一个诚实的帐户，以上帝的办公室交给我们，恳请在主，由父亲的情感和律师，皇帝，国王，王子，公爵， marquises ，计数，大亨，和其他的任何其他贵族，卓越，主权，电力，卓越或尊严，他们可能是，我们命令他们凭藉神圣服从，遵守上述宪法和使他们inviolably观察其议题，尽管海关无论任何与此相反的，如果他们希望避免的神圣不满和拟合反应使徒见。

An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a is ofIgG1 isotype, b shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum when compared to such an assay without said antibody, and d shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 M in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum when compared to such an assay without said antibody has improved properties in antitumor therapy.

一种已经提高了抗肿瘤治疗的特性的抗体，所述抗体结合IGF-IR并且抑制IGF-I和IGF-II与IGF-IR结合，其特征在于所述抗体a是IgG1同种型，b显示其对IGF-I与IGF-IR结合的抑制的IC 50 值与其对IGF-II与IGF-IR结合的抑制的IC 50 值的比率为1∶3-3∶1，c当与没有所述抗体的这种测定比较时，其在5nM的浓度上，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3细胞的细胞磷酸化测定中，抑制至少80％的IGF-IR磷酸化，所述3T3细胞提供400，000-600，000分子IGF-IR/细胞，和d当与没有所述抗体的这种测定相比，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3的细胞磷酸化测定中，其在10μM的浓度上没有显示作为IGF-IR磷酸化所测量的IGF-IR刺激活性，所述3T3提供400，000-600，000分子IGF-IR/细胞。

Once any such stock certificate is issued and during the period that the Plan holds the Restricted Shares, Officer shall be entitled to all rights associated with the ownership of shares of Common Stock not so held, except as follows: if additional shares of Common Stock become issuable to Officer with respect to Restricted Shares due to an event described in Section 6 below, any stock certificate representing such shares shall be issued in the name of the Plan and delivered to the Committee or its representative and those shares of Common Stock shall be treated as additional Restricted Shares and shall be subject to forfeiture to the same extent as the shares of Restricted Shares to which they relate; if cash dividends are paid on any shares of Common Stock subject to the terms of this Agreement, those dividends shall be reinvested in shares of Common Stock and any stock certificate representing such shares shall be issued in the name of the Plan and delivered to the Committee or its representative and those shares of Common Stock shall be treated as additional Restricted Shares and shall be subject to forfeiture to the same extent as any other Restricted Shares; and Officer shall have no rights inconsistent with the terms of this Agreement, such as the restrictions on transfer described in Section 4 below.

一旦任何此类股票证书已颁发，在计划持有受限股的期间，管理人员有权享有与持有相应普通股股份有关的一切权利，但以下情况除外：如果由于以下第6条中所述的事件，导致可向管理人员发行额外的普通股股份，则任何代表该等额外股份的股票证书应以计划的名义发行并交付给委员会或其代表，且该等普通股股份应被视作额外的受限股，并和与其相关的受限股遵守同样的没收规定；如果对服从于本协议之条款的任何普通股股份支付现金股息，该等股息应重新投资到普通股股份中，任何代表该等股份的股票证书应以计划的名义发行并交付给委员会或其代表；以及管理人员不得拥有任何与本协议之条款（比如下述第4条中所述的转让限制）不一致的权利。

Read and write of flash disk as USB host.According to the request of this subject, the system hardware and software for the slave device, and the communication interface to the master PC are developed. Detailed works are as follows: in order to implement the measurement principle in the system, flow-liquid levelmethod is used;velocity of flow is measured through rotor Kinemometer;water level is surveyedvia RS485 interface and pressure sensor;the C8051F060 chip which is in high performance andintegration, produced by Silicon Laboratories Company as master chip is used to capture and measure the width of impulses, so singals of flow velocity are collected and disposed;the 4×4 matrix keyboard and LCD are used in the part of man-machine interface which are easy to input, legible to read, various to display, comfy to be accepted and plain to show measure and inquiry results;FRAM memory FM3164 is used to carry out the non-volatile memory of data and accurate real-time clock.;SL811HST chip is used as USB host which can read and write flash disk,thereby a kind of adscititious mass storage is accomplished .

根据研制任务的要求，课题期间主要完成了下位机系统硬件和软件，设计了与上位机的通讯界面，所做的具体工作包括：测量原理在系统中的实现，采用了流速—水位计算法，通过旋桨式流速仪来测量流速，通过RS485接口与压力变送器通讯测量水位；主控制芯片采用了Silicon Laboratories公司的高性能、高集成度C8051F060芯片，利用其捕捉测脉宽的特性，实现了流速信号的采集和处理；人机接口部分采用了4×4矩阵键盘和LCD显示，输入方便，读数清晰，显示多样化，信息量大，易于被用户接受，更直观地显示测量及查询结果；通过采用铁电存储器FM3164实现了数据的非易失性存储和精确的实时时钟；通过采用SL811HST芯片，实现了USB主机的功能，可读写U盘，从而实现了单片机的外挂式海量存储。

The author comes to some conclusions as follow: The Khanate of Kipchak kept the submissive relation to the house of the grand khan and supported the supreme khan of Mongol Empire in the inner politics and the policy to the outside, which gave certain supports to the early communication in the Mongol Yuan dynasty; The Khanate of Kipchak should account for the stop of the communication caused by the foundation of the Khanate of Ogotai which had been supported by the Khanate of Kipchak during the period of the reign from Berke to Mangu Timur; The short-time stop of the communication was also Mongolian central government"s tragedy. The relationships of the Khanate of Kipchak to Yuan dynasty began to become normal during the course of the reign of Tuda Mangu ,Tula-buqa and Toqatai khan, in which the Khanate of Kipchak gave certain devotions to "peace" of the Mongol Khanates. Their relations had been best after the separation of Mongol Empire during the time of ozbeg and Janibeg"s reign which was. the rush hour of our economic and cultural intercourses with the Khanate of Kipchak and other west countries. The development of the relationships to Egypt accelerated the intercourses between this two countries, which indirectly widened the ways of the Sino-Arab communication in the economy and cultures. The relations to Ire Khanate had been very bad for a long time. This stopped the convergence of the Steppe Silk Roads and the Oasis Silk Roads. In other side, this helped the intercourses between Ire Khanate and Christian Europe.

本文认为，蒙古帝国时期，无论在内政还是外交方面，钦察汗国都维护着蒙古大汗的权威，保持着与蒙古大汗廷的臣属关系，这为蒙元早期中西经济文化交流需要的条件做出了一定贡献；别儿哥至忙哥帖木儿统治时期，钦察汗国应对因窝阔台汗国的崛起而导致的中西交通的阻断负一定责任，但这同时也是蒙古中央政府的悲哀；脱脱蒙哥至脱脱统治时期，两国关系开始逐渐恢复，钦察汗国为蒙古诸汗国的&约和&贡献了自己的力量；月即别和札尼别统治时期是两国关系的最密切时期，也是双方经济文化交流和中西交通的高峰期；钦察汗国与埃及关系的发展，一定程度地拓宽了中阿经济文化交流的渠道；钦察汗国与伊利汗国关系恶化和长期的紧张，一方面阻碍了草原丝路与绿洲丝路的交汇，另一方面促进了伊利汗国与欧洲的经济文化交流。

Enterprises must innovate the marketing tactics and marketing way in order to meet knowledge type customer"s demands, Knowledge marketing has offered solved tools as innovative mode of marketing those enterprises in era of knowledge-driven economy, in the marketing system of knowledge, traditional 4Ps marketing association tactics also have been given the new meaning, formed the 4Is marketing association tactics (such as Individual product and service, Price Indenture, The Platform Bases onInternet, Knowledge Intercourse)that have already been realized and proved in practice, Except the innovation of marketing association, the way of knowledge marketing is innovating constantly too, Learning Marketing and Experience Marketing is two ways among them, They direct against three kinds of rare resources on the knowledged customer to design concrete marketing method, tool in order to obtain the knowledged customer"s attention and trust separately, Learning Marketing attracts the attention of the knowledged customer according to the knowledge learning and exchanging of enterprises" marketing employee, management employee and the whole society. Experience Marketing let knowledged customer participate in the course of the products or the service according to consumption experiencing, a kind of special marketing mode. Not only met the characteristic that the knowledged customer is fond of participation but also obtained the knowledge type customer"s trust.This article includes five chapters:Chapter one preface introduces such questions as writing background, original intention of the selected title and thinking frame in the writing course of this article and expounds the reason emphatically that how to choose knowledged customer to summarize the new customer group. Study is a way to obtain knowledge; knowledge is an achievement of study also includes the customer"s self- innovation, meanwhile, proves to the small difference between the customer and customer.Chapter two put forward the knowledged customer"s concept, defines the knowledge customer"s definition and analyze its intension and epitaxy, also discusses rare resources on the knowledged customer. This article defines the knowledged customer as those groups and individuals that utilize knowledge to guide one"s own consumption practice and constant study and carry on the knowledge innovation constantly, they have completely new traits different from the old customer, time

企业必须对营销策略和营销方式进行创新以满足知识型顾客的需求，知识营销作为知识经济时代企业的一种营销创新模式为我们提供了一个解决工具，在知识营销体系中，传统的4Ps营销组合也被赋予了新的意义，形成了4Is营销组合(即个性化的产品和服务Individual product and service、基于协商下的价格约定Price Indenture、基于网络的信息技术平台The Platform Bases on Internet、知识的交流Knowledge Intercourse)，4Is营销组合已被越来越多的企业意识到并在企业的营销实践中得到了验证；除了营销组合的创新，知识营销的营销方式也在不断地创新，学习营销和体验营销便是其中两种方式，它们针对知识型顾客身上的三种稀缺性资源设计具体的营销方法、工具分别用以获取知识型顾客的注意力和信任度，其中学习营销通过企业内部营销人员、管理人员和企业外部全社会的知识学习、交流来吸引知识型顾客的注意；体验营销则通过消费体验这种特殊的方式让知识型顾客参与到产品或服务的过程

If you thought he is very graceful, wants to go with him to be in love, please think something; If you thought she is very beautiful, wants to go with her to be in love, please think something; If you thought very lonelily, wants to go to ask a person to be in love, please think something; If you only are because has listened to friend's several spoken , goes to and somebody is in love, please give up.

如果你觉得他很帅，想去和他谈恋爱，请三思；如果你觉得她很美，想去和她谈恋爱，请三思；如果你觉得很孤单，想去找一个人谈恋爱，请三思；如果你只是因为听了朋友的几句言语，就去和某个人谈恋爱，请放弃。

This is embodied by the following five transformations:i,from method-centrism to problem-centrism,i.e.to advocate that it is the problem researched thatdetermines research methods rather than vise versa:ii,"fromscientific objectivism"to"daoistic objectivism",i.e.to emphasize the daoistic conveniency;iii,from reductionismto holistic dynamism,i.e.to see a person and his mind and behavior as a coherent totalityrather than the sum of his functioning parts;iv,from the"thing"paradigm to"human"paradigm,i.e.to emphasize to bring those unique characteristics that makes a person as aperson back into psychological researches,which have been lost by mechanomorphicpsychology;v,from"single science"to"integrated science",i.e.to emphasize integratedthinking based on multiple levels to replace the traditional dichotomous thinking,and thusmake"humanistic science"to enclose"mechanomorphic science"in multi-levelintegration.

它具体体现在以下五大转变：（1）从方法中心论到问题中心论。主张问题决定方法，方法必须适合于问题。即，心理学应以&人&为出发点构建方法论，而不应不顾自身特性生搬硬套自然科学的方法论。（2）从&科学的客观&到&道家的客观&。

Moreover, the actual allele frequency of most varieties deviates far from Hardy-Weinberg equilibrium. All PPB、na 、I、h、Gi and Fst have proved to be the references to elucidate that ISSR is a most powerful tool to analyze genetic diversity, compared with the RAPD marker and the allozyme marker is less strong ordinally. We could divided the 70 samples into A, B, C, D and E five groups using three methods according to genetic distance clustering. There is a bit displacement for few varieties in different clustering maps, but the most are similar to morphological analysis despite that there is still a great difference among cultivars in the same one group. The above results imply that the three methods have the different sensitivity and resolution in genetic distance analysis of close varieties. The Mantel test indicates that the results from the three kinds of markers have the significant correlation, which demonstrates that the number of the used three kinds of markers is enough to exactly detect the diversity of all 70 samples to ideal extent. And these methods can be used to evaluate the diversity of the whole group using the miscellaneous samples instead of the individual sample, of the Gerbera jamesonii are mainly from tissue culture plants. In conclusion, the above study results provide a reference for the application of three kinds of molecular markers to molecular marker-assisted breeding of flower. 2. The genetic diversity among the eight introduced cut-flower varieties of Ranunculus asiatica was analyzed by the ISSR markers. Based on the genetic clustering tree, all the colorful flower varieties are clustered into one group, and the white flower varieties into another group. Moreover, among the former group the yellow flower varieties are clustered into one sub-group, and the reddish flower varieties, such as rose color, pink, nacarat, are clusetered into another sub-group.

由三种分子标记的分析结果可以看出，等位基因平均值、观察杂合度、Fis值、Fit值皆较高，表明非洲菊等位基因较丰富，杂合基因偏多，且绝大部份品种的实际等位基因频率在品种内偏离了Hardy-Weinberg equilibrium；PP8、na、Ⅰ、h、Gi及Fst皆表明，ISSR检测遗传多样性的能力最强，其次是RAPD，等位酶最低；根据遗传距离进行聚类，三种方法都把70个品种分成A、B、C、D、E五个大组，每一组中除少数品种发生位移外，大部份品种分类结果相似，且与形态分析结果有相似性，但在每一组中，品种间的聚类差别较大，表明这三种方法在近距离品种间检测遗传变异时灵敏度及分辨力不同；Mantel检测表明，三种标记的分析结果有显著相关性，表明所用的三种分子方法的标记数量已经可以相对无偏地检测到70个品种间遗传变异；非洲菊为组培苗，三种标记的检测结果皆表明，混合样品可以作为个体样品的代表，对整个居群的遗传多样性进行评价；这些研究结果可为三种分子标记方法在花卉分子辅助育种中的进一步应用提供借鉴。

Rapid cell selected, regional, rows or columns: the mouse click to select the current cell; click the region to be selected first cell, and then drag the mouse to the last cell can be two selected region between; worksheet click the Select All button, you can select the current worksheet; hold down the Ctrl click or drag using the mouse, you can select multiple nonadjacent cells or regional; select a region first cell, hold down the Shift key click on the angle of regional cells, can be between the selected rectangular area; click the line number can be selected corresponding to the entire line; click out the corresponding label can be selected out of the whole; along its line number or a list of drag the mouse, or to select the first row or first column, hold down the Shift key to select the end of the row or column, you can select a number of adjacent rows or columns; first select the first row or first column, and then hold down the Ctrl key to select other non-adjacent rows or columns; If you want to increase or decrease in the activities of the cell area can be selected by holding down the Shift key click the lower right corner of the region the last cell, the cell activities and the click between the cells will become a rectangular area to select a new region.

快速选中单元格、区域、行或列：鼠标单击可以将当前单元格选中；单击待选中区域的第一个单元格，然后拖动鼠标至最后一个单元格，可以将两者之间的区域选中；单击工作表的全选按钮，可以将当前工作表选中；按住 Ctrl 单击或使用鼠标拖动，可以选中不相邻的多个单元格或区域；选中某区域的第一个单元格，按住 Shift 键单击区域对角的单元格，可以将两者之间的矩形区域选中；单击行号可将对应的整行选中；单击列标号可将对应的整列选中；沿行号或列表号拖动鼠标，或者先选中第一行或第一列，按住 Shift 键选中结束行或列，就可以选中相邻的多个行或列；先选中第一行或第一列，然后按住 Ctrl 键选中其他不相邻的行或列；如果您想增加或减少活动区域中的单元格，可以按住 Shift 键单击选中区域右下角的最后一个单元格，活动单元格和所单击的单元格之间的矩形区域就会成为新的选中区域。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。