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There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

Yes, she said, say she has run over for to ask the Apthorps to be sure and come to the auction and buy this house, because she allowed her uncle Peter would ruther they had it than anybody else; and she's going to stick to them till they say they'll come, and then, if she ain't too tired, she's coming home; and if she is, she'll be home in the morning anyway.

如果那样的话，她会回家来的。如果这样，至少她在早上会回家来的，她还说，关于普洛克托斯家，什么也别说，只提阿贝索贝斯家便行了——这是完全实实在在的话，因为她去那里是为了讲她们买下房子的事。

Yes, she said, say she has run over for to ask the Apthorps to be sure and come to the auction and buy this house, because she allowed her uncle Peter would ruther they had it than anybody else; and she's going to stick to them till they say they'll come, and then, if she ain't too tired, she's coming home; and if she is, she'll be home in the morning anyway.

是的，她说她要过去求阿贝索贝斯家务必到拍卖的现场来，并且买下这座房子，因为她认定，彼得大伯宁愿由他们家而不是别的人家把这座房子买下来。她准备缠着他们不放，直到他们答应会来。如果能说通，并且她还没有累倒，她就会回家来。如果那样的话，她会回家来的。

Model of animals were established by putting rats in a container with slippy inner wall and half-full of water in it, letting them swimming freely till died of being drowned. Each rat from different groups was killed by breaking its neck except drowning group, then BW and SO_2 was detected, and its chest was cut open rapidly, lung was taken out and weight was measured accurately to count lung coefficient. Its lung appearance was observed and lung tissue was fixed with formalin, which was made into pathology slices with HE staining, and pathology change of the lung tissue was observed;Expression of IL-8 and IL-10 in lung tissue was detected with Immunocytochemistry, and correlation between them was analyzed .

动物模型制作采用将大鼠放入盛有黄河水的内壁光滑的容器内，让其自由泳动自然溺死，除溺水致死组外，各组动物分别在规定的时间点断头处死，行体重和血氧饱和度等指标检测，并在冰盘中迅速开胸取肺，准确称重以计算肺系数，观察各组大鼠肺脏外观，取肺组织福尔马林固定，制成病理切片HE染色，光镜下观察肺组织病理改变；用免疫组化的方法检测肺内IL-8、IL-10的表达，并对其相关性进行分析研究。

Well, by and by the king he gets up and comes forward a little, and works himself up and slobbers out a speech, all full of tears and flapdoodle about its being a sore trial for him and his poor brother to lose the diseased, and to miss seeing diseased alive after the long journey of four thousand mile, but it's a trial that's sweetened and sanctified to us by this dear sympathy and these holy tears, and so he thanks them out of his heart and out of his brother's heart, because out of their mouths they can't, words being too weak and cold, and all that kind of rot and slush, till it was just sickening; and then he blubbers out a pious goody-goody Amen, and turns himself loose and goes to crying fit to bust.

随后国王站了起来，朝前走了几步，酝酿好了情绪，哭哭啼啼作了一番演说，一边眼泪直流，一边胡话连篇，说他和他那可怜的兄弟，从四千英里外，仆仆风尘赶到这里，却失掉了亲人，连最后一面也未见到，心里有多难过，只是由于大伙儿的亲切慰问和神圣的眼泪，这样的伤心事也就加上了一种甜蜜的滋味，变成了一件庄严的事，他和他兄弟从心底里感谢他们。因为嘴里说出的话无法表达心意，语言委实太无力、太冷淡了。如此等等的一类废话，听了叫人要吐。最后胡诌了几声&阿门&，又放开嗓子大哭一场，哭得死去活来。

Well, by and by the king he gets up and comes forward a little, and works himself up and slobbers out a speech, all full of tears and flapdoodle about its being a sore trial for him and his poor brother to lose the diseased, and to miss seeing diseased alive after the long journey of four thousand mile, but it's a trial that's sweetened and sanctified to us by this dear sympathy and these holy tears, and so he thanks them out of his heart and out of his brother's heart, because out of their mouths they can't, words being too weak and cold, and all that kind of rot and slush, till it was just sickening; and then he blubbers out a pious goody-goody Amen, and turns himself loose and goes to crying fit to bust.

随后国王站了起来，朝前走了几步，酝酿好了情绪，哭哭啼啼作了一番演说，一边眼泪直流，一边胡话连篇，说他和他那可怜的兄弟，从四千英里外，仆仆风尘赶到这里，却失掉了亲人，连最后一面也未见到，心里有多难过，只是由于大伙儿的亲切慰问和神圣的眼泪，这样的伤心事也就加上了一种甜蜜的滋味，变成了一件庄严的事，他和他兄弟从心底里感谢他们。

No shoot, says Friday, no yet, me shoot nom, me no kill; me stay, give you one more laugh; and indeed so he did, as you will see presently; for when the Bear see his Enemy gone, he comes back from the Bough where he stood; but did it mighty leisurely, looking behind him every Step, and coming backward till he got into the Body of the Tree; then with the same hinder End foremost, he came down the Tree, grasping it with his Claws, and moving one Foot at a Time, very leisurely; at this Juncture, and just before he could set his hind Feet upon the Ground, Friday stept up close to him, clapt the Muzzle of his Piece into his Ear, and shot him dead as a Stone.

不打，&星期五说：&还不打。现在不开枪，我不打它。我呆在这儿，再让你们乐一下。不久，我们就看到，他真的这样干了。因为那熊见他的敌人走了，也就从它站着的树枝上往后退。但它往回走的时候极其从容不迫，每走一步，都要回头看一下。退着退着，它终于退到树干上来。

No shoot, says Friday, no yet, me shoot nom, me no kill; me stay, give you one more laugh; and indeed so he did, as you will see presently; for when the Bear see his Enemy gone, he comes back from the Bough where he stood; but did it mighty leisurely, looking behind him every Step, and coming backward till he got into the Body of the Tree; then with the same hinder End foremost, he came down the Tree, grasping it with his Claws, and moving one Foot at a Time, very leisurely; at this Juncture, and just before he could set his hind Feet upon the Ground, Friday stept up close to him, clapt the Muzzle of his Piece into his Ear, and shot him dead as a Stone.

你不到我这儿来，我到你那儿去。说完，他爬到树枝的末梢，那地方只要用他的体重一压，就会垂下来。他轻轻从树枝上滑下来，等到他离地不远时，一下子就跳到地上，飞也似地向他的枪跑过去，把枪拿在手里，站在那里一动也不动。

No shoot, says Friday, no yet, me shoot nom, me no kill; me stay, give you one more laugh; and indeed so he did, as you will see presently; for when the Bear see his Enemy gone, he comes back from the Bough where he stood; but did it mighty leisurely, looking behind him every Step, and coming backward till he got into the Body of the Tree; then with the same hinder End foremost, he came down the Tree, grasping it with his Claws, and moving one Foot at a Time, very leisurely; at this Juncture, and just before he could set his hind Feet upon the Ground, Friday stept up close to him, clapt the Muzzle of his Piece into his Ear, and shot him dead as a Stone.

主人！但他毕竟是个勇敢的男子汉，立即催马冲到向导跟前，拿起手枪，对着那只狼的头上就是一枪，结果了那畜牲的生命。可怜的向导应该说运气不错，因为他碰上了星期五。星期五在他家乡与野兽打惯了交道，所以一点也不害怕。他能坦然地走到狼的跟前，一枪把它打死。要是换了别人，就不敢靠得那么近开枪了。而从远距离开枪，不是打不着狼，就是可能打着人。即使像我这样胆大的人，见此情景也着实吓得心惊肉跳。说实在的，我们一行人都吓得魂不附体，因为，紧跟着星期五的枪声，我们就听见两边的狼群发出一起最凄惨的嚎叫，山谷里又发出阵阵回声，结果狼嚎和回声此起彼伏，犹如成千上万的狼在吼叫。说不定来的狼确实也不止这几只，要不，我们也不至如此惊恐万状了。星期五打死了那只狼之后，另一只本来紧咬着马不放，登时也松了嘴逃跑了。幸亏这只狼咬住了马头，马勒头上的铁圈刚刚卡住了狼的牙齿，因而马没有受什么伤。可是向导的伤可不轻，因为那只激怒了的野兽一共咬了他两口，一口咬在肩膀上，一口咬在他膝头上方。而且，当星期五上前把狼打死时，他那匹受惊的马几乎把他摔了下来。不用说，一听到星期五的枪声，我们立即催马向前。

At length he would reach the corn, and selecting a suitable ear, frisk about in the same uncertain trigonometrical way to the topmost stick of my wood-pile, before my window, where he looked me in the face, and there sit for hours, supplying himself with a new ear from time to time, nibbling at first voraciously and throwing the half-naked cobs about; till at length he grew more dainty still and played with his food, tasting only the inside of the kernel, and the ear, which was held balanced over the stick by one paw, slipped from his careless grasp and fell to the ground, when he would look over at it with a ludicrous expression of uncertainty, as if suspecting that it had life, with a mind not made up whether to get it again, or a new one,or be off; now thinking of corn, then listening to hear what was in the wind.

最后，它终于到了玉米旁，拣定一个玉米穗，还是用那不规则三角形的路线跳来跳去，跳到了我窗前堆起的那一堆木料的最高峰上，在那里它从正面看着我，而且一坐就是几个小时，时不时地找来新的玉米穗，起先它贪食着，把半裸的穗轴抛掉；后来它变得更加精灵了，拿了它的食物来玩耍，只吃一粒粒的玉米，而它用一只前掌擎起的玉米穗忽然不小心掉到地上了，它便做出一副不肯定的滑稽的表情来，低头看着玉米穗，好像在怀疑那玉米穗是否是活的，决不定要去拣起来呢，还是该另外去拿一个过来，或者干脆走开；它一忽儿想看玉米穗，一忽儿又听听风里有什么声音。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。