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Itamin D from the skin and diet is metabolized in the lier to 25-hydroxyitamin D (Figure 1), which is used to determine a patient's itamin D status1,2,3,4; 25-hydroxyitamin D is metabolized in the kidneys by the enzyme 25-hydroxyitamin D-1-hydroxylase (CYP27B1) to its actie form, 1,25-dihydroxyitamin D.1,2,3,4 The renal production of 1,25-dihydroxyitamin D is tightly regulated by plasma parathyroid hormone leels and serum calcium and phosphorus leels.1,2,3,4 Fibroblast growth factor 23, secreted from the bone, causes the sodium–phosphate cotransporter to be internalized by the cells of the kidney and small intestine and also suppresses 1,25-dihydroxyitamin D synthesis.5 The efficiency of the absorption of renal calcium and of intestinal calcium and phosphorus is increased in the presence of 1,25-dihydroxyitamin D (Figure 1).2,3,6 It also induces the expression of the enzyme 25-hydroxyitamin D-24-hydroxylase (CYP24), which catabolizes both 25-hydroxyitamin D and 1,25-dihydroxyitamin D into biologically inactie, water-soluble calcitroic acid.2,3,4

从皮肤和食物来的维生素D在肝中代谢为25-羟基维生素D（图1），被用来决定病人体内维生素D情况的1，2，3，4；25-羟基维生素D在肾中被25-羟基维生素D1羟化酶（CYP27B1）转变为有活性的1，25-二羟基维生素D 。1，2，3，4由肾产生1，25-二羟基维生素D是被血浆甲状旁腺激素和血清钙，磷水平紧密调节。1，2，3，4由骨分泌的成纤维细胞生长因子23使钠磷协同转运蛋白被肾和小肠细胞内化及抑制1，25-二羟维生素D合成。5 在1，25-二羟基维生素D作用下肾和小肠吸收钙及磷的效率增高(图1)。2，3，6 它也包括25-羟四- 24 -羟化酶的表达(CYP24)，且将1，25二羟基维生素D和25羟基维生素D异化成无生物活性，水溶性的维生素D3-23羧酸。2，3，4

He chisels a hole on wood but the hole does not fit the chisel tightly.

用凿子在木头上敲一个洞，这洞口与凿头一定不密合。

A few words of explanation, an embrace, a kiss on the cheek and then the chloroformed pad of cotton wool thrust in her face and held tightly against her nose and mouth.

几句解释，一个拥抱，在她脸颊上印一个吻，然后他将填满麻醉剂的棉花羊毛衬垫猛堵在她脸上，紧紧捂住她的鼻子和嘴。

The front and center channel speakers are made with a bamboo diaphragm which provides a tightly intertwined fiber to deliver greater rigidity and accuracy, resulting in clear reproduction of sounds over a wide frequency range, from massive explosions to metallic clangs.

前方和中央声道扬声器均采用竹隔膜提供一个紧密交织纤维以提供更大的刚性和精度，造成清晰的声音再现了一个宽的频率范围，从大爆炸到金属 clangs。

It examines its hand - flexes it, then clenches it tightly.

它检查了自己的手——先弯曲，然后紧握拳头。

You can caress her whole body while pulling yourself hard into her and if she clenches her buttocks while you are inside of her and hold you into position, you will be able to feel her vagina wrapped tightly squeezing your penis, this will send you wild.

你可以抚抱她全身一面拉入自己辛勤clenches她，如果她和她的臀部，但你认为你入内，她的立场，你能感受到她的阴道紧紧包裹着你挤阴茎，这个野生将派你。

He shouted, his hands clenching the arms of his chair so tightly they shattered.

他呼喊，他的紧握他的椅子手臂如此的紧紧他们的手打碎。

Tightly clenching goals of economic growth, confidence in Pudong, a new series of strategic design is brewing.

紧咬经济增长目标不放，浦东充满信心，一系列新的战略设计正在酝酿。

She still clutched tightly in his letter that he still clutched the beating of her heart ......

她还在紧紧的攥着他的那封信，攥着他仍然为她跳动的心

Make the pressurize loop coalesces with the pressurize pedestal tightly .

圈与密封座紧密联合，起到关闭作用。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。