查询词典 tight-clenched

Borneol ; in vitro blood-brain barrier model ; Matin-Darby canine kidney epithelial cells ; intercellular tight junction ; pinocytosis vesicle

冰片；血脑屏障体外模型；马丁达比狗肾上皮细胞；细胞间紧密连接；细胞吞饮囊泡

MethodsBorneol contained serum was prepared and using Matin-Darby canine kidney epithelium cell line as the in vitro BBB model to observe the effects of borneol on intercellular tight junction and pinocytosis vesicles of BBB model.

方法制备含冰片的家兔血清，应用马丁达比狗肾上皮细胞系作为血脑屏障的体外模型，观察冰片对血脑屏障细胞间紧密连接、细胞吞饮囊泡的影响。

We discovered that the mechanisms of borneol opening BBB involved (1) promoting the tight junction of endothelial cells opening:(2) increasing the quantity of pinocytosis vesicle in endothelial cells and enhance the pinocytosis;(3) inhibiting the activation of P-glycoprotein (P-glycoprotein is an efflux pump of drugs) and increase the permeability of BBB;(4) reducing the expression of intercellular adhesion molecule-1 in brain microvessel endothelial cells;(5) increasing the concentration of Ca〓 in brain microvessel endothelial cells;(6) increasing the activation of eNOS in brain microvessel endothelial cells.

随后，在对冰片开放血脑屏障的机制作进一步的研究时又发现，冰片开放血脑屏障的机制包括以下几个方面：(1)冰片可使血脑屏障内皮细胞间的紧密连接开放；(2)冰片能使内皮细胞内的囊泡数量增加，吞饮功能增强；(3)冰片能抑制P-糖蛋白的活性（P-糖蛋白是一种药物外排泵），而使血脑屏障的通透性增加；(4)冰片能使脑微血管内皮细胞ICAM-1表达量减少；(5)冰片使脑微血管内皮细胞内的Ca〓浓度升高；(6)冰片可升高脑微血管内皮细胞eNOS的活性。

HA increased level of NO by activating NOS after combining with H〓 and H〓 receptors; and on the one hand 5-HT caused brain microvessel endothelial cells constracting strongly, made the tight joint opening, increased the permeability of BBB, and on the other hand 5-HT increased the quantity of pinocytosis vesicle in endothelial cells and enhance the permeability of BBB after comining with 5-HT〓 receptor.

HA与H〓和H〓受体结合，激活NO合成酶，使NO含量增多而诱发BBB通透性增加；5-HT与5-HT〓受体结合，一方面引起脑微血管内皮细胞强烈收缩，使内皮细胞间的紧密连接开放，BBB通透性增高，另一方面可引起内皮细胞转运小泡增加，BBB通透性增高。

When necessary, injection of vitamin D3 injection. 2, Do not think that baby touch "small鸡鸡"一摸thought of "sex", the children are still very small not mind adults; to children check whether I have stems, pinworm, eczema, pants too tight and so on.

必要时注射维生素D3针剂。2、不要以为孩子摸"小鸡鸡"，一摸就想到"性"，孩子还小没有大人的想法；给孩子检查一下有否我茎、蛲虫、湿疹、裤子太窄太紧等。

Wet genital disease, inflammation, pinworm disease, wet diapers or pants tight foreskin phimosis caused by inflammation, such as stimulation, can cause local genital itching, followed by friction, on the basis of the development of habits of action, but also Some children can not find a clear incentive.

外阴部的湿症、炎症、蛲虫症，尿布潮湿或裤子太紧，包茎引起的包皮炎症等刺激，都可引起外阴局部发痒，继而摩擦，在此基础上发展为习惯性动作，也有一些患儿找不到明显的诱因。

However, too often some of the reasons may be related to the following: the one, local stimulus, such as perineal cleaning baby care too much, genital eczema, pinworm, wet diapers or pants too tight and so on stimulation. 2, psychological factors, if the children were the family atmosphere of tension, lack of motherly love, suffer discrimination and so emotionally can not be met through its own stimulus to seek vent, resulting in leg movements folder. 3, larger children may be related to puberty by sex-related stimuli.

但过于频繁可能与以下一些原因有关：1、局部刺激，如对孩子会阴部清洁护理过多、外阴湿疹、蛲虫、尿布潮湿或裤子太紧等等的刺激。2、心理因素，如有的儿童因家庭气氛紧张、缺乏母爱、遭受歧视等，在感情上得不到满足，通过自身刺激来寻求宣泄，从而产生夹腿动作。3、大一点的的孩子可能与进入青春期、受到与性有关的刺激有关。

Although his tight schedule means he rather pelts through the continent, his eye for detail and his elegant pen give a flavour of each country he crosses: great veldts and high plateaux, Congo's "green vastness", the "sandy seas" of the Sahel and, finally, the fertile plain of the north African coast.

尽管行程非常紧张，只能对非洲大陆略知一二，但他观察仔细、形象地描述了经过的每一个国家，例如大草原、高原、刚果广袤的绿地、西非一望无际的沙漠，最后还有北非沿海肥沃的平原。

When your plop a heart for pouring in the underground, our class clenches a while tight.

当您扑通一声倒在地下时，我们班的心一下子揪紧了。

Choose the corresponding mobile connection cable from the package and plug in the power input interface of our cellphone; put one environment friendly AA battery into the charger and cover the back cover tight; plug the other end of the connection cable into the plughole in the front of the charger; when the red indicator light flickers, the charging is working for your cell phone.

从包装盒里将对应的手机连接线选出，并插入到你的手机电源输入口；将一节5号环保电池装入充电器中旋紧后盖；将连接线的另一端插入充电器的头部插孔中；当红色指示灯闪烁时表示已经实现为手机应急充电；其他手持设备的充电方式亦相同。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。