查询词典 thymocytes

Effect of Aconite Injection on the Spontaneous Incorporation of ~3H-TdR into Thymocytes in the Mice of Radiation Damage

目的 观察乌头注射液对辐射损伤小鼠胸腺细胞自发掺入3 H -TdR的作用。

"It is expected that these thymocytes will develop anergy to the donor antigens," lead author H.L.

印度Ahmedabad城市医院研究中心和肾脏疾病研究所的Dr。

To study the protective effects of polypeptide from Chlamys farreri on thymocytes damaged by H_2O_2 and antioxidative mechanisms of PCF,we made a thymocytes damaged-H_2O_2 model.

在有氧代谢过程中，机体会产生少量的活性氧，这些ROS可以被机体内存在的抗氧化酶和非酶抗氧化剂所清除。

Objective To study the toxicity of fluoride on thymic epithelial cells and thymocytes , and to explore its mechanism.

目的 研究氟化物对胸腺上皮细胞的毒性作用及对胸腺细胞发育的影响，探讨其作用机制。

MLT was given to mice through intraperitoneal injection 60 min before the whole-body irradiation with 2 Gy X-rays. Twenty four hours after irradiation, the number of thymocytes and splenocytes, 3[KG*3]H-TdR incorporative rate of thymocytes and T and B lymphocyte transforming rates induced by Con A and LPS were observed.

在此基础上，腹腔注射MLT，观察2GyX射线全身照射后24h小鼠胸腺、脾脏淋巴细胞数量及胸腺细胞3H-TdR掺入率和ConA、LPS诱导的脾T、B淋巴细胞转化率的变化。

We found that intravenously administered arginine significantly decreased the spleen weight, the serum interleukin-6 level, and IL-6 production by leukocytes, splenic macrophages, and thymocytes; significantly decreased tumor-necrosis factor-α production of leukocytes and thymocytes; and significantly increased the stimulating index of cell proliferation in T-thymocytes in peritonitic rats.

结果显示，静脉给予arginine显著降低腹膜炎大鼠脾脏重量、血清间白素-6、与白血球、脾脏巨噬细胞及胸腺细胞IL-6分泌量，且显著降低白血球与胸腺细胞肿瘤坏死因子-α分泌量，但显著增加胸腺细胞增生的刺激指数。

Results: 1. The value of all experimental indexes decreased significantly after heat stress, and reached the lowest at the time 2-8 hours after heat stress. This indicates that the immunity of the mice is damaged to the largest extent at 2-8 hours after heat stress. 2. L-arginine supplementation with appropriate dose could remit the acute atrophying of thymus and spleen tissue caused by heat stress. 3. After L-arginine supplementation with appropriate dose, the lymphocyte proliferation, the level of concentration of IL-2 and * expression of IL-2R raised in the group with room temperature; in the heat stress group the level of three indexs decrease significantly. Furthermore, the decrease of the group given 1 .Smglg.bw L-arginine is the smallest. This result indicates that the concentration of 1 .Smglg.bw L-arginine supplementation could remit the depressment of the immunity caused by heat stress. 4. The [Ca2~] in activated thymocytes of the group with L-arginine -2- supplementation is significantly higher than that of the group with water supplementation. This indicates that L-arginine supplementation could protect thymoeytes of mouse under heat stress. We also found that the fluorescence intensity of [Ca2~] in activated thymocytes of the group given 1 .Smglg.bw L-arginine is the highest.

结果：1、热应激后小鼠的各项免疫指标均有显著性下降，其中在2.8小时降到最低，提示在这个时间段小鼠的免疫功能受到最大损害；2、适量补充精氨酸有助于缓解热应激导致小鼠胸腺和脾脏的急性萎缩；3、常温组，补充适量精氨酸后小鼠淋巴细胞增殖活性、IL-2的浓度及IL-2R的表达均有显著性上升，而热应激后三指标均显著降低，其中在精氨酸给予浓度为1.5mg/g.bw时三指标的降低程度最少，提示该浓度可最大程度缓解热应激对小鼠免疫功能的抑制；4、补充精氨酸组的活化胸腺细胞［Ca~(2+)］较给水组有显著性上升，说明精氨酸对热应激小鼠胸腺细胞具有保护作用，并发现在精氨酸给予浓度为1.5mg/g.bw时活化胸腺细胞的胞浆钙离子荧光强度达到最大；5、热应激后小鼠血清NO的浓度均有不同程度的上升，补充精氨酸后血清NO上升更加明显，但并非随精氨酸给予浓度的增加而增加。

When normal rat thymocytes were cocultured with serum prepared from castrated animals, the proliferative activity of thymocytes was enhanced.

当正常的胸腺细胞以去势动物的血清来培养时，它的增殖活性也增强了。

RESULTS The results indicated that PCF could significantly increase the viability of thymocytes and enhance the activities of SOD, GSH-Px, CAT in cells. PCF decreased the amounts of ROS and the rate of apoptosis in cells. PCF inhibited the morpholog alteration of the thymocytes irradiated by UVB and maintained the ultrastructure of cells in normal. PCF attenuated UVB caused DNA fragmentation in thymocytes. While combined ERKs inhibitor yielded typical DNA fragmentation, co-treatment of thymocytes with PCF and JNKs and p38 kinase inhibitors completely blocked UVB-induced DNA fragmentation.

结果 PCF能显著提高UVB辐射后小鼠胸腺淋巴细胞的活性；提高胞浆中SOD、GSH-px、CAT的活性，降低ROS含量及细胞凋亡率；抑制UVB辐射所致的胸腺淋巴细胞凋亡的形态学改变，维持细胞的正常超微结构；抑制UVB所致的胸腺淋巴细胞DNA片段的出现；预先应用ERK抑制剂使DNA片段增加，给予JNK和P38抑制剂后协同PCF使DNA片段带减少。

The result indicated different expression of CD3,CD4,CD8 on large thymocytes and small thymocytes.

结果表明，胸腺中大胸腺细胞和小胸腺细胞的CD3、CD4及CD8的表达不同，在大胸腺细胞中，CD3的表达比小胸腺细胞的CD3 表达要高出10个百分点。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。