查询词典 thymidine

objective to study the relationship of thymidine phosphorylase with the degree of differentiation, lymph node metastasis, angiogenesis and prognosis of gastric carcinoma.

目的 分析胸苷磷酸化酶在胃癌中的表达情况及其与患者年龄、性别、分化程度、淋巴结转移、肿瘤内微血管密度及预后的关系，探讨tp的临床病理学意义。

Objective To study the expression of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in breast cancer and its correlation with prognosis.

目的 探讨乳腺癌组织中胸苷酸化酶、胸苷酸合成酶和二氢嘧啶脱氢酶mRNA表达水平及其与预后的关系。

Objective To study the expression of thymidine phosphorylase and the counts of lymph vessels and their olinicopathalogical signifioances in non-small cell lung cancer tissues.

目的 研究非小细胞肺癌组织中胸普磷酸化酶的表达和淋巴管计数，探讨其临床病理意义及其相互关系。

Objective: To furthur study dual impact on thymidine phosphorylase mRNA expression and apoptosis in vitro in hepatocellular carcinoma cells by interferon-alpha.

目的 进一步研究干扰素-α对人肝细胞癌胸苷磷酸化酶表达水平及细胞凋亡的双重影响。

Their structures were identified by chemical and spectral analysis. RESULTS Five compounds were isolated and identified as stigmasterol 3-O-β-D-glucopyranoside, 20β-hydroxy-ecdysone,β-L-thymidine, pennogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside and pennogenin 3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)-]-β-D-glucopyranoiside.

结果 分离并鉴定了5个化合物，分别是Δ5，22-豆甾醇3-O-β-D-葡萄吡喃糖苷，20β-羟基蜕皮激素，β-L-脱氧胸腺嘧啶苷，偏诺皂苷元3-O-α-L-鼠李吡喃糖基－(1→2)-β-D-葡萄吡喃糖苷和偏诺皂苷元3-O-α-L-鼠李吡喃糖基－(1→4)-α-L-鼠李吡喃糖基－(1→4)-［α-L-鼠李吡喃糖基－(1→2)-］-β-D-葡萄吡喃糖苷。

At the 8th week cellular immunity was detected by an unprimed proliferation test of the spleenocytes by using a [^3H]-thymidine incorporation assay.

目的观察携带弓形虫表面抗原复合基因重组沙门氏菌经口免疫BALB/c小鼠所诱导的免疫反应。

Progesterone increased the formation of the CDK2-p21 and CDK2-p27 complexes, but not the CDK4-p21 and CDK4-p27 complexes. Moreover, the assayable CDK2, but not CDK4, activity was concentration-dependently decreased by progesterone treatment.

藉由同时给予p21与p27反义寡核苷酸造成p21与p27的表现被抑制，会回复助孕酮所产生之胸腺嘧啶核甘标记嵌合([3H]thymidine incorporation)的抑制。

To find methylated genes, researchers usually turn to a technique called bisulphite sequencing, which chemically changes normal cytosine to thymidine (T; another DNA base), while leaving methylated cytosines unchanged.

研究者通常借助于亚硫酸氢盐测序技术检测甲基化的基因，它通过化学反应使正常胞嘧啶转变为胸腺嘧啶，而对甲基化的胞嘧啶无作用。

The results showed that:(1) Many proliferating cells were distributed unevenly in the ventricular zone of telencephalon, and the [3H] labeled cells were found to be populated in the lateral ventricular zone of neostriatum at brain level L12~L14,forming proliferation "hot spots";(2) Having underwent mitosis twice, the proliferative cells in the VZ began to migrate laterally 6 days after intramuscular injection of [3H] thymidine, and these migrating precursor cells terminated at their targets and differentiated into new neurons on the 30th day.

结果发现：①端脑室带区中存在不均匀分布的[3H]标记细胞，大量标记细胞分布在端脑尾侧新纹状体水平(L1～L14)的VZ，形成标记细胞的&热点&区；②标记细胞经两次有丝分裂后，大约在肌肉注射[3H]的第6天后开始从VZ向外迁移，在30天左右到达目的脑区并分化成为成熟神经元。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。