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The frequency value in S phase is 4. 83 times of M phase, 2. 9 times of G1 phase, and 3. 41 times of unsynchronized cells. These results suggested that gene correction events were highly related to S phase. Then we compared the targeting efficacy for two groups of cells in S phase. One group was contact with thymidine and the other one went smoothly through S phase without replication blockage.

基于这种原因，我们对基因定点修复事件做了细胞周期定位分析，发现同步于S期的细胞群发生定点修复的效率明显高于其它各期以及非同步化的细胞，流式细胞仪检测S期定点修复效率为M期细胞的4.83倍，为G1期细胞的2.9倍，是未同步化细胞的3.41倍。

Methods The mice were intragastrically administered with Wikstroemia Liquid for 90 days continuously. The doses of Wikstroemia Liquid were 60 times, 30 times, 15 times as human daily doses. The mice condition, major hematological indexes, blood biochemical and organ pathological tissues changes were observed during medicine administration, at the end of medicine treatment and resuscitation stage after medicine treatment.

取复辣液分别相当于人日用量的60倍、30倍、15倍，经90天小鼠灌胃给药，观察给药过程中、给药末期及停药恢复期动物的一般状况，主要血液学、血液生化学和脏器病理组织变化。

There were 15 pediatric ALL patients, which had received 50 times of chemotherapy with HD-MTX. The records about blood concentration of MTX and clinical conditions for 50 times chemotherapy were divided into two groups. Group I: contained 25 records of stand-risk patients, administering MTX 3.0g/m2; Group II: contained 25 records of mid and high-risk patients, administering 5.0g/m2. Continuous intravenous dripped MTX for 24th in both two groups, while implemented hydrating and alkalizing for 4 days. All patients were rescued 6 times through leucovorin, 15mg/m~2, since 12th after the end of MTX dripping. Then examined the blood concentration of MTX by fluorescence polarization immunoassay approach at 24h, 44h, 68h, at the same time inspected liver function, blood routine examination, the occurrence time and degree of toxicological reactions.

观察15例ALL住院患儿，接受大剂量MTX共50例次，按ALL危险度分2组，低危治疗组接受MTX剂量为3.0g/m2为I组；中高危治疗组接受MTX剂量为5.0g/m2为II组，连续静脉点滴MTX共24小时，同时给予水化碱化治疗，共4天，全部病例均在MTX滴注结束后12小时开始静脉推注四氢叶酸钙(leucovorin，LV)解救，15mg/m2/次，共6次，采用免疫偏振荧光法检测药物滴注24、44、68小时MTX血药浓度，同时检测两组病例的肝功、血常规，观察临床出现MTX毒副反应的时间及程度，观察每个病例毒副反应出现程度与MTX血药浓度关系，两组毒副反应程度比较，进行统计学分析。

Your forever friend gets you through the hard times,the sad times,and the confuses times.

你真正的朋友会与你一同度过困难，伤心和烦恼的时刻。

The delegates voted 10 times, 20 times, 30 times.

代表们投了10次、20次、30次。

The results showed that:(1) In COPD group the alveolar walls were broken. The average area of alveolars was 2.46 times as big as the control group, and the average diameter was 1.42 times as compared with the control group. As the diameter of bronchioles was less than 100μm and 100～200μm respectively, the average area of smooth muscle in bronchioles increased to 3.06-fold and 2.13-fold respectively. By electron microscopic, the proportion of Clara cells of respiratory bronchioles in COPD group decreased, the Clara cells were denaturalized, the proportion of Clara cells containing low density secretory granules increased. The airway resistance was 1.84 times while the dynamic compliance was only 70.45% comparing with the control group.

结果表明：(1)光镜下，COPD组大鼠与正常对照组比较，肺泡壁破坏、肺泡腔扩大，平均肺泡面积和平均肺泡直径分别为正常对照组的2.46倍和1.42倍，在直径＜100μm及直径100～200μm的小支气管，COPD组大鼠支气管平滑肌面积分别为正常对照组的3.06倍和2.13倍；电镜下可见，在呼吸性细支气管，Clara细胞占上皮细胞的比例下降，细胞变性，含低电子密度颗粒的Clara细胞比例增加；呼吸功能测定可见COPD组大鼠呼气相气道阻力是正常对照组的1.84倍、动态呼吸系统总顺应性为正常对照组的70.45％。

Isoniazid 100mg+Amikacin 200mg+Dexamethasone 2 mg were insufflated to the focus before and after operation. KTP laser therapy periods were 2 to 5 weeks, once weekly, therapy times were 1 to 2 seconds times 10 to 20, and intermittent times were 2 to 3 seconds, therapy current was 10A+.

KTP激光治疗2~5周，每周1次，每次治疗时间1、2s×10~20s，间歇2、3s，治疗电流10A+，导光纤维0.4mm或0.6mm，脉搏血氧计监视患者术前、术中、术后的心率和血氧饱和度的变化。

Accordingly, I would say,"I love you" for millions and billions of times, and times and times again.

因此，我会说，&我爱你&数百万数十亿的时候，和时代和时代的一次。

In new "The course reformation of the basic education" the Ministry of Education pointed out:the purpose of new curriculum should reflect the requirements of the times,so that help students gradually develop a correct world outlook, outlook on life and values and training students' creative spirit and practical ability,science and humanistic quality,the awareness of environmental protection.This new concept must have times color—advancing with the times.

当今教育部新一轮《基础教育课程改革纲要》中指出：新课程的培养目标要体现时代的要求，使学生逐步形成正确的世界观、人生观、价值观，具有初步的创新精神、实践能力、科学和人文素质以及环保意识，这种新理念必须具有时代的色彩----与时俱进。

In addition, the value of new business, the Chinese counterpart of the safety of the new business at 14 times the value of the multiplier; China Life new business value of the corresponding multiplier for 33 times, 18 times that of China Pacific Insurance; assessment Value has become conservative, he thought the insurance industry in China due to policies of protection, as opposed to other industries, in this round of economic adjustment, the insurance industry the impact would be relatively small, the effect will become a safe haven.

此外，新的商业价值，新业务的安全中对应的14倍乘数的价值；中国人寿新业务价值相应的33倍，18倍乘数对中国太平洋保险，评估价值变得保守，他认为，由于在中国的保护政策，而不是其他行业在这一轮的经济调整，保险业，保险业的影响将相对较小，效果会成为一个安全的避风港。

You can buy sweetened beverages, if that suits you.

你若喜欢的话，可以买些含有糖精的混合饮料。

As many of you are probably aware, Nick and Vanessa were recently faced with an embarrasing sex scandal after naked pictures of the two getting jiggy with it in a hot tub surfaced the net.

正如很多你可能知道，尼克和 Vanessa 最近面临一个尴尬的绯闻事件后，赤裸裸的图片两个越来越jiggy与它在浴缸中的一个热点浮现净。