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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析，并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography，FFA)、吲哚青绿血管造影(indocyanine green angiography，ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例，73.5%)，双眼同时患病118例(80.8%)；后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%)；前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例，98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%)；后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障；毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现；炎症活动期FFA典型表现为斑驳状高荧光，ICGA发现脉络膜血管扩张、通透性增高等改变；VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎，随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

4Without discrimination, allow reasonable time for other Members to make comments in writing, discuss these comments upon request, and take these written comments and the results of these discussions into account.

2.9.4无歧视地给予其他成员合理的时间以提出书画意见，应请求讨论这些意见，并对这些书面意见和讨论的结果予以考虑。

TBT2.9.4 without discrimination, allow reasonable time for other Members to make comments in writing, discuss these comments upon request, and take these written comments and the results of these discussions into account.

至于这场争端的起因，除了日本企业的"开发进口"之外，中日双方专家和舆论都提到"无协调机制，无民间渠道"是重要原因。

Five novel torsion-mirror optical actuators including double-beam thickness differential structure with single torsional axis, double flexible folded-beam structure with single torsional axis, double-beam vertical torsion comb structure with single torsion axis, four-beam differential compound-micromirror structure with double torsional axis and the combined structure of the four basis forms above, are brought forward. All of these devices could be fabricated by the same silicon micromachining process we have developed. The deformation compensation design with local enhancement for the thin torsional beam which is the key structure of these devices is also put forward to improve the reliability. The three-dimension solid model and two-dimension reduced order model of the torsion-mirror optical actuator are established and then the numerical simulations for evaluating the device characteristics of the statics, dynamics, electrostatic field, mechanical and electrostatic coupling, fluid and solid coupling are carried out to optimize the structure design. Furthermore, three optical fibre clamping structures which could be integrated monolithicly are designed and analyzed to improve the optical coupling capability. 4. Three flexible process flows combined with bulk silicon micromachining and surface silicon micromachining are brought forward to fabricate these novel single-crystal silicon or polysilicon torsion-mirror optical actuators by using the same lithography masks for both SOI wafer and regular silicon wafer. A series of important process experiments are carried out to optimize the process parameters and the process flows. Some novel and typical process phenomena which occurred during the microfabrication are analyzed and then the corresponding solutions are put forward. 5. A MEMS dynamic testing system which exploit blur image synthetic technique, stroboscopic image matching technique, stroboscopic mirau microscopic interferometry technique and microscopic laser dopper vibrometer technique is set up to measure three-dimension and six-freedom micro motions of any MEMS devices with nanometer resolution.

在对硅微机械扭转镜光致动器的光机电特性系统地理论研究的基础上提出了硅微机械扭转镜光致动器的结构设计准则。3、提出了单轴双梁厚度差分结构、单轴双柔性折叠梁结构、单轴双梁垂直扭转梳齿结构、双轴四梁差动复合微镜结构以及以上四种基本结构组合后的衍生结构等五种工艺加工技术兼容的新型的硅微机械扭转镜光致动器，对器件关键结构薄厚度、高耐疲劳扭转梁进行了局部加强的变形补偿设计，建立了器件的三维实体模型以及两维降阶模型，对提出的新结构硅微机械扭转镜光致动器进行了系统的静力学、动力学、静电场、力电耦合和流体固体耦合的建模仿真与优化设计，同时设计并分析了三种可实现单芯片集成的弹性光纤定位夹紧结构。4、提出了组合体硅微加工技术与表面硅微加工技术、兼容同一套光刻版图、可分别基于SOI 晶片和普通Si 晶片、适应于制造提出的各种新结构单晶硅和多晶硅硅微机械扭转镜光致动器的三套柔性加工工艺流程，开展了一系列重要工艺步骤的单项工艺试验，对工艺流程与工艺参数进行了优化，针对加工过程中出现的具有普遍意义的典型工艺问题进行了讨论和分析，并提出了解决方法。5、创新性地将模糊图像合成技术、频闪图像匹配技术、频闪Mirau 显微干涉技术与显微激光多普勒测振技术有机结合，建立起了一套周期运动测量与瞬态运动测量相结合、单点运动测量与全视场运动测量相结合、满足不同MEMS 器件各种动态测试要求的集成的MEMS 三维六自由度微运动精密测量系统。

People like us have absolutely no understanding of these events, and with us completely not understanding, you bring them these facts. They'll just suppose these are the grumblings of a down-and-out writer and nothing more.

象我们这样的人对这些事情完全不了解，而完全不了解的情况下你就拿这些给他们，他们只能认为这是你们这些落魄文人发的牢骚而已。

The main problems that the patient suffered from are: 1. The dejecta is leaked to vagina for unknown reason; 2. The break happened in the suture the fifth day after the 3rd duodenostomy surgery, and therefore, the dejecta is out from here instead of the ostomy tube made in the 2nd surgery; 3. A 15-centimeter-long wound by the surgery does not heal for a long time. All these problems could not be solved for a long time. For these reasons, the patient has already suffered from these and stayed in bed for nearly 3 months.

病人现在的主要问题是：一是阴道内出大便，二是第三次手术小肠缝合处在第五天接口崩开，现所有大便从小肠漏口排出，而原直肠造漏口不再有大便排出，三是腹部长约15公分手术刀口一直开敞而不愈合，国内的医生对病人的病情没有解决办法，致使病人已经卧床将近3个月不能下床，每天遭受着病痛的折磨，过着地狱般的生活。

As the body response for the trauma, the adipose tissues as blood serum behavior in the wounded tissue were suffered mobilization. At the same time, the ectogenesis fat tissue entranced blood circulation. As the result of hemodynamics alteration, there were blood platelet and erythrocyte and leucocytes and lipid granules collecting on the surface of these lipid droplets. The volumes of these lipid droplets were enlargement. These lipid droplets were changed to fat embolus by the promotion of coagulation and fibrin deposition intra-blood vessel.

现代医学理论认为，外伤后组织存留的血清状态的脂肪组织受到动员，同时，损伤部位的血管外源性脂肪进入血循环，而创伤引起的机体反应使血液动力学发生改变，血小板、红细胞、白细胞及血脂乳化不稳定所析出的脂质颗粒等，均可聚集于以上脂滴的表面，使之体积增大，加之组织凝血活化酶的释放，促使血管内凝血，纤维蛋白沉积的发生，从而形成脂肪栓子，导致脂肪栓塞。

This may eventually cause problems with patient access to these new therapies, the editorial suggests. All of the targeted therapies available to date are added onto conventional treatment, thus adding costs to the healthcare system."When the goal is to improve the chance for a cure, these new treatments seem to be well worth the expenditure," comments editorialist Hyman Muss, MD, from the Vermont Cancer Center, in Burlington."However, when the goal is to improve the quality of life or delay the time to progression by several months, as it is with many treatments for metastatic breast cancer, it is less clear whether the health system can and should bear these expenses."

当病患最终接触到这些新疗法时可能会发生问题，主编表示，目前为止，这些新的标靶疗法都是加在传统疗法之上，这对医疗系统造成负担；布灵顿Vermont 癌症中心Hyman Muss医师表示，当目标放在治癒时，这些新疗法是值得研究的，然而，当目标放在改善生活质量与减缓疾病进程时，仍有许多其它疗法可以选择，这些新药物应用在这种情形下的角色仍不清楚，且应该考虑医疗系统是否能够或是是否需要负担这些费用。

As for a given automata,there exists three cases:for some state which did not being visited, for some state itself indeed being not reachable although it has been visited,for some state it is equivalent to other states though it can be reached to, in these three cases it is obviously redundant to construct these automata, and the only way for us is to delete,integrate and reduct these useless states in order to minimize the number of states.

对于一个给定的自动机，它的状态中有一些根本没有被访问过，有一些尽管被访问过，但是本身是不可达的，有一些状态尽管是可达的，但是在功能上却与另一些状态等价，这样的自动机在设计和应用中显然很累赘，可以将一些无用的状态删掉，将另外一些等价状态进行整合和约简，使之状态数达到极小。

Unspeakable, who sitst above these Heavens To us invisible or dimly seen In these thy lowest works, yet these declare Thy goodness beyond thought, and Power Divine: Speak yee who best can tell, ye Sons of Light, [ 160 ] Angels, for yee behold him, and with songs And choral symphonies, Day without Night, Circle his Throne rejoycing, yee in Heav'n, On Earth joyn all ye Creatures to extoll Him first, him last, him midst, and without end.

这是言语所难以形容的。您坐在诸天之上，我们看不到您，但看见您这些最卑微的作品，就可略知一二；这些东西已经宣说您的至德和无比的神奇。说吧，您最能说会道的，光明之子，天使们呀，因为你们看见他，你们在天上，便用歌词和交响曲，昼夜不停地围绕着他的宝座欢唱，在地上的芸芸众物呀，你们合声歌颂他，起、承、转、合，永不停息。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。