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NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.
通过研究,我们提出了初步的NodD操纵子激活模型:第一,四聚体是NodD蛋白的功能单位,它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子;第二,小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体,在我们的模型中,NodD四聚体缩小其V形主体的弯折角,进而缩短其DNA结合功能域的间距;第三,小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用,NodD的构象改变由蛋白质经其双铆钉位点传递给DNA;第四,只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物;第五,不排除NodD与RNA聚合酶可能有直接的相互接触位点,不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物,但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。
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Broke estate wind water, a five favorable because, first, home of the popular wave is advancing wave upon wave, the wave of tidehead Guanwaidichan as one has not been 关内 Nanshan "substitutes" have been contained, rather because work gets big cake, enjoy more Gospel; Second, the department kilometer momentum to continue sweeping, that the current direction is still a certain potential to be tapped village, but village has water reserves for the development of land, and only broke with the village close to successfully enjoy Phuket real estate situation favorable to the extension; Third, broke a vast reserve of land and 11 million square metres of land available for the real estate industry highly competent, and broke the natural environment unique, for the development of high-quality flats for the rich soil; Fourth, Shenzhen, Guangzhou, Zhongshan and Zhejiang, and other well-known developers have about broke, overseas Chinese,"Guangzhou Biguiyuan,""Zhongshan Garden Music" will be successfully settled in that the supply of real estate market is rapidly broke assembly, formed; Fifth, further spread kilometer race, For kilometer property kilometer race with the actual contribution to local economic development, then broke to "miss"!
2000年横岗地产风声水起,得缘于五大利好,其一,全民置业化浪潮一浪高过一浪,关外地产作为这一浪潮中的潮头之一,并未因关内南山&替代品&的出现受到抑制,反倒因为蛋糕越做越大,享受到更多福音;其二,布吉片区发展势头继续势如破竹,显示目前布吉方向仍有一定潜力可挖,但是布吉可供开发土地储备已经告急,而横岗与布吉只是咫尺之遥,使横岗可望享受到布吉地产形势利好的延伸;其三,横岗土地储备丰厚,1100万平方米土地可供地产界游刃有余,同时,横岗自然环境得天独厚,为开发高素质楼盘预备了丰厚的土壤;其四,深圳、广州、中山及浙江等地知名地产商纷纷看好横岗,中国海外、&广州碧桂园&、&中山雅居乐&等即将在横岗落脚,表明横岗地产供应市场正在迅速集结、形成;其五,片区竞赛进一步蔓延,片区竞赛对于片区地产的实际贡献与对于当地经济的发展有目共睹,使横岗不愿再&错失良机&!
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We kept our Arms ready, and our Eyes about us, but we saw no more Wolves,'till we came thro' that Wood, which was near half a League, and entred the Plain; as soon as we came into the Plain, we had Occasion enough to look about us: The first Object we met with, was a dead Horse; that is to say, a poor Horse which the Wolves had kill'd, and at least a Dozen of them at Work; we could not say eating of him, but picking of his Bones rather; for they had eaten up all the Flesh before We did not think fit to disturb them at their Feast, neither did they take much Notice of us: Friday would have let fly at them, but I would not suffer him by any Means; for I found we were like to have more Business upon our Hands than we were aware of.
我们手里紧握着枪,眼睛紧盯着四面八方。可是在我们穿过那座一英里多长的树林,进入平川地以前,再也没有看见过别的狼。等我们一进入平川,向四下一望,头一眼就见到一匹死马。这是一匹被狼群咬死的马,同时见到至少有十二条狼在那里大吃特吃;其实,马肉早就给它们吃光了,现在正在啃马骨头呢!我们感到不应该去打扰它们的盛宴,何况它们也没有注意我们。星期五本来想向它们开枪,可是我怎么也不同意。因为我感到,我们的麻烦还在后面呢,尽管我们现在还不知道。
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In that memorable struggle for superiority between the rival houses of AUSTRIA and BOURBON, which so long kept Europe in a flame, it is well known that the antipathies of the English against the French, seconding the ambition, or rather the avarice, of a favorite leader,[10] protracted the war beyond the limits marked out by sound policy, and for a considerable time in opposition to the views of the court.
在那场令人难忘的奥地利王室和波旁王室之间为争夺优势的让欧洲陷入长期的战火的战争中,大家都知道,英国人憎恨法国人,他们支持他们喜爱的君主的野心,更确切的说是贪婪,将战争延续到了合理策略所要求停战的时间之后了,而且在相当长的时间内是违背王室的意见的。
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Meditation Alone/ firefly译 The Moon Is Mine The moon is mine And the sundries I home mail It's thin, cool and dark Like me under an unlucky star Who stay out straying, with a sadly sorrowful look When facing it You should feel esteem--in my opinion Also you could Weep when looking at it, and Be put in a tight spot, or Behold a man in it coming out Lay Open the Loneliness Lay open the loneliness, perhaps There be no loneliness Under the alone lamp, in the empty room The whole world's dyed orange with rays Everything represents nothing As someone been far away The deserted heart still misses Only lonely is still lonely Wine for one, when wine round three times for one Think of the drip drops, the fallen leaves, and Some time, some seasons, some persons, some Sundries when warm Like I lay open the loneliness Then nothing to keep lonely The Tree All the leaves in this tree fall Its loneliness falls into a face It's limpid and bright Where the sun shines There are blares of colored glaze Exclaim occasionally, or profoundly Stride one's line of sight, such height and weald Straying there --Why there is no wild Divide the Rain Drips Divide the dense rain drip Then you may see decaying scene-- A man in the sun walking with vigorous strides In the shallow puddle Immerges half his nose, spraying Continuous ripples It's simply a groundless guess at daytime Or rather a dream, yet that's it And that I see Sun's weak, and see The sun and water turns to be blank in the air Nov.
16th, 2007 原诗:《独想》《那些月光是我的》那些月光是我的是我寄给家里的物什它薄薄的,凉凉的,暗暗的就像我的薄命流浪在外,神情悲悯你们面对它应该感到高贵——这是我的想法你们也可以看着它流泪,看着它一筹莫展,或者看着一个人从里面走出来《把孤独摊开》把孤独摊开,或许就没有孤独了在孤灯下,空屋里万物都染着桔色的光万事都不代表什么就像远去了一个人心中空荡荡的,却总有惦念但孤独还是孤独的一个人的酒,一个人酒过三巡想想窗檐的滴水,想想落叶,想想一些时间,一些季节,一些人物,一些那时感到有温度的物什就如同把孤独摊开了没什么可继续孤独的《这棵树》这棵树落光了叶子它的孤独就成了一张脸它清澈与明亮太阳光照的地方,全然是时空中一簇琉璃的光泽偶尔让人惊叹,偶尔骨感地跨入人的视线,那样的旷野和高度停留在那里——为什么没有荒芜《把雨点分开》把稠密的雨点分开就可以看到颓废的景观——一个刚在太阳下健步如飞的男人在浅水坑中浸入了一半的鼻子,喷着连续不断的涟漪这只是我白日的一个臆念有点梦,但就是这样我才看到了阳光的软弱,看到了阳光和雨水原来就是一场空中之茫
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What that means is that the relationship between the coding system of language on the one hand and the conceptualizing system of thought on the other is conventional rather than genetic.
回想一下,在第一章中我们认为语言是用于人类交际的任意符号体系。其意思是,语言的符号体系和思维的概念体系之间的关系是约定俗成的,而不是固定的。
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Galileo's greatest glory was that in 1609 he was the first person to turn the newly invented telescoped on the heavens to prove that the planets revolve around the sun rather than around the Earth.
伽利略的最光辉的业绩在于他在1609年第一个把新发明的望远镜对准填空,以证实行星是围绕太阳旋转而不是围绕地球的。
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When I meet the engine with its train of cars moving off with planetary motion —— or, rather, like a comet, for the beholder knows not if with that velocity and with that direction it will ever revisit this system, since its orbit does not look like a returning curve —— with its steam cloud like a banner streaming behind in golden and silver wreaths, like many a downy cloud which I have seen, high in the heavens, unfolding its masses to the light —— as if this traveling demigod, this cloud-compeller, would ere long take the sunset sky for the livery of his train; when I hear the iron horse make the hills echo with his snort like thunder, shaking the earth with his feet, and breathing fire and smoke from his nostrils(what kind of winged horse or fiery dragon they will put into the new Mythology I don't know), it seems as if the earth had got a race now worthy to inhabit it.
当我遇见那火车头,带了它的一列车厢,像行星运转似的移动前进,——或者说,像一颗扫帚星,因为既然那轨道不像一个会转回来的曲线,看到它的人也就不知道在这样的速度下,向这个方向驰去的火车,会不会再回到这轨道上来,——水蒸汽像一面旗帜,形成金银色的烟圈飘浮在后面,好像我看到过的高高在天空中的一团团绒毛般的白云,一大块一大块地展开,并放下豪光来,——好像这位旅行着的怪神,吐出了云霞,快要把夕阳映照着的天空作它的列车的号衣;那时我听到铁马吼声如雷,使山谷都响起回声,它的脚步踩得土地震动,它的鼻孔喷着火和黑烟(我不知道在新的神话中,人们会收进怎样的飞马或火龙),看来好像大地终于有了一个配得上住在地球上的新的种族了。
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" There is no critical boundary between speculation and investment, especially when all participators are immersed in delighted atmosphere, There is nothing so easier than large amount of unearned money that can lead person to loss the logos. Even more normal person will lose his head, after such kind of experience mentioned. The more time they stay in the dancing party, that is invest much capital into the speculative operation, the larger the proportion of The Pumpkin carriage and mouse driver show the hoof is. All of them intend to stay to the last minute rather than miss any minute of the dancing party. But the point is there is no pointer in the clock at all." Buffett wrote these words to shareholders in 2000 years.
&股神&巴菲特2000年写给股东的信中写道:&投资与投机之间永远是一线之隔,尤其是当所有市场的参与者都沉浸在欢愉的气氛当中时更是如此,再也没有比大笔不劳而获的金钱更让人失去理性,在经历过这类经验之后,再正常的人也会像参加舞会的灰姑娘一样被冲昏了头,他们明知在舞会中多待一会-也就是继续将大笔的资金投入到投机的活动之上,南瓜马车与老鼠驾驶现出原形的机率就越高,但他们还是舍不得错过这场盛大舞会的任何一分钟,所有人都打算继续待到最后一刻才离开,但问题是这场舞会中的时钟根本就没有指针!&
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It is common knowledge and rather obvious that contemporary art and pop culture have been influencing and mixing up with each other with ever stronger momentum. Generally speaking, such phenomenon is caused by the following factors: first of all, pop culture is an unavoidable existence in the field of the contemporary social culture, especially in urban culture. Elements of pop culture are always employed by artists who attempt to present the modern social life in a critical, ironical or neutral way. But their standpoint and intention of choosing the visual resources are different from that of the mass media and the public.
众所周知,在当代社会中艺术与大众文化的相互渗透、混杂的现象已经明显加剧,造成这种现象的原因大致有这么几点:首先,大众文化是当代社会文化领域,特别是都市文化领域中一个不能回避的问题,不管艺术家是处于批判、反讽或者是不动声色的呈现当代社会生活的时候都涉及到运用大众文化形态的问题,只不过艺术家选择这些视觉资源的时候其出发点及立场与大众传媒和社会公众不同。
- 推荐网络例句
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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.
然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。
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Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.
镀锌钢托盘多用于出口,替代木托盘,免薰蒸,符合欧盟、北美各国对出口货物包装材料的法令要求;喷涂钢托盘适用于重载上货架之用,托盘表面根据需要制作成平板状、波纹状及间隔形式,满足不同的使用要求。
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A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.
付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。