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Result: A 77-year-old female presented at our hospital for blurred vision in her right eye. The intraocular pressure was 46 mmHg and slit lamp examination showed a protruding mass with papillomatous appearance near pupil margin. On chest X-ray examination, only prominent left hilum was noted. Iris tumor excisional biopsy was performed. Pathology investigation of the surgical specimen revealed carcinoma and immunohistochemical study demonstrated thyroid transcription factor-1 (TTF-1) positive. Chest-computed tomography showed left upper lung tumor and primary pulmonary adenocarcinoma was confirmed after CT-guided biopsy. She was placed under treatment with Genfitinib. Recurrent iris tumor mass was noted during follow-up, and chest CT revealed shrinkage of adenocarcinoma.

结果:一位七十七岁女性因右眼视力模糊至本院就诊,当时眼压为46毫米汞柱,细隙灯检查发现虹膜靠近瞳孔边缘有一乳突状肿块,胸部X光摄影仅见左肺门稍明显并未发现明显病灶,患者接受虹膜肿瘤切除手术,病理报告显示为恶性肿瘤,且免疫组织染色为thyroid transcription factor-l阳性,进一步的胸部电脑断层显示左上肺肿瘤,经电脑断层指引之切片检查证实为原发性肺腺癌,她接受Genfitinib药物治疗,后续追踪发现虹膜肿瘤复发,胸部电脑断层扫描显示肿瘤体积缩小。

Abstract] objective to discuss radiological findings of parosteal osteosarcoma on emphasis combined with clinical pathology and literature.methods 4 cases of parosteal osteosarcoma proved by operation and pathology were analyzed retrospectively.results female was 3 cases,male was 1 case,average age was 30.5 years old,these tumors were arised on posterior border of distal femur and popliteal cavity,presented as lobular dense ossified mass,defined lesion.one case had villose margin.a thin narrow lucent zone separated the mass from the cortex at two cases.one case underwent angiography,there was no malignant feature.conclusion parosteal osteosarcoma may be divided into low-grade type and high-grade type.radiological manifestations of early stage possess character,early diagnosis conduces to establish rational treating plan and evaluate prognosis.

目的 结合临床病理学特征和文献资料,重点讨论皮质旁骨肉瘤的x线特征。方法收集经手术、病理证实的皮质旁骨肉瘤病例4例,对其进行回顾性分析。结果 4例患者女3例,男1例,平均年龄30.5岁,肿瘤均发生于股骨远端后侧和腘窝处,表现为分叶状致密骨化肿块,边界清晰,其中1例边缘呈绒毛状改变,2例有细窄透亮带与骨皮质相隔,1例行血管造影,未见血管池等恶性征象。结论皮质旁骨肉瘤分为低度恶性和高度恶性两种,早期影像学表现有特征性,早期诊断有助于制订相应的治疗方案和评估预后。

The suitable reaction parameters were found that mole ratio of potassium persulphate to sodium sulfite,mole percent of initiator and mole percent of BS relative to total monomer, mass percent of total monomer in water, mass percent of surfactant in water, reaction temperature,pH value and reaction time are 3:1,0.06%, 1.45%,20%,5.5%,50 ℃,6 - 7 and 12 h, respectively.

研究得到了适宜的反应条件:n(K2S2O8):n(Na,SO3)=3:1,引发剂和Bs相对于单体总量的摩尔分数分别为0.06%和1.45%,总单体在水里的质量分数为20%,SDS在水里的质量分数为5.5%,pH=6—7,反应温度50℃。

The results showed that the low-molecular weight sodium polyacrylate from 2 000 to 4 000 were obtained when reaction temperature was 70 ℃,acrylic acid mass fraction was 20 %~30 %,the mass ratio of potassium persulphate to sodium hydrogen sulfite was 10∶1~14∶1,and reaction...

对合成的聚丙烯酸钠在陶瓷铁粉上进行应用试验,当聚丙烯酸钠加入量为0.3%~0.5%时,所得浆料粘度较小,有良好的分散效果。

Restoration of beta cell mass through pharmaceutically induced endogenous beta cell mass expansion may reolutionise diabetes therapy.

通过药物诱导内源性β-细胞群膨胀来恢复β-细胞群可能是糖尿病的革命性疗法。

Restoration of beta cell mass through pharmaceutically induced endogenous beta cell mass expansion may revolutionise diabetes therapy.

通过药物诱导内源性β-细胞群膨胀来恢复β-细胞群可能是糖尿病的革命性疗法。

Restoration of beta cell mass through pharmaceutically induced endogenous beta cell mass expansion may reolutionise diabetes therapy.

通过药物诱导内源性β-细胞群膨胀来恢复β-细胞群功能可能是糖尿病的革命性疗法。

After the cell growth curves was recorded, RPE cells of the 3-5th passages were utilized. 2、Three different siRNA (siRNAl,siRNA2,siRNA3) targeting against human cx43 gene and one negative control siRNA were designed and transfected into cultured human RPE cells via liposome reagent. The most effective siRNA can be determined by semi-quantitative reverse transcription PCRRT-PCR. 3、To the most effective siRNA, after transfected into human RPEs with different concentration, the cellular proliferate activities were messured by MTT colorimetry ; the percentages of RPE in different cell circle phase was assayed by FCM; the changes of phenotypical properities were observed with SCM; the protein expression of cx43 was studied through immunocytochemistry stain and Weston blot; the communication intercellular was calculated with FRAP; and the ability of recovery was assessed by using an in vitro wound healing model.4、The total proteins of siRNA1 and RPE were seperated by two-dimensional gel electrophoresis and visualized by silver staining. Proteins with significant expression alterations were selected and their peptide mass fingerprints (PMFs were obtained by matrix-assisted laser desorption/ionization time of flying mass spectrometry (MALDI-TOF-MS).The PMFs were used to search NCBInr database by Auto MS-Fit software.

实验方法:1、培养原代的人RPE细胞,经过细胞角蛋白、S-100和神经胶质原纤维酸性蛋白免疫细胞化学鉴定后,通过AO/PI染色技术确定培养细胞的存活率,描记其生长曲线,第3-5代用于以下细胞实验2、生物合成针对人cx43基因的三条小干扰RNA和一条阴性RNA通过脂质体转染RPE细胞后,通过RT-PCR的方法确定抑制效率最高的干扰片断3、将该片段以不同浓度通过阳离子脂质体转染培养的人RPE细胞后,采用MTT法观察其对细胞的增殖力的作用;通过流式细胞仪观察其对细胞周期的影响;通过扫描电镜观察其对细胞形态的影响;通过免疫细胞化学和Weston blot观察其对cx43蛋白表达的作用;采用激光共聚焦和荧光淬灭恢复技术观察荧光恢复速率平均百分率,评价其对细胞间通讯功能的影响;通过制作RPE细胞损伤模型,观察其对损伤修复能力的作用4、分离纯化转染siRNA的RPE组和正常对照组RPE细胞的全部蛋白质,应用等电聚焦电泳和SDS-PAGE双向电泳技术,银染显示分离出的蛋白质斑点,经凝胶图像分析软件对两个样本进行胶图分析,寻找差异蛋白点。

MRI findings usually fall into 2 categories: 1 A soft tissue mass that is hypointense on T1-weighted images and hyperintense on T2-weighted images with diffuse homogeneous or slightly heterogeneous enhancement within the collection; 2 As the phlegmonous mass necroses, there may be a peripherally-enhancing fluid collection.

MRI表现通常被分为两类:1)软组织肿块,T1低信号,T2高信号,病灶内弥漫均匀性或轻度不均匀强化;2)当表现为蜂窝组织炎坏死时,表现为边缘强化的积液。

Visual carbon stars whose mid-infrared spectra are mainly dominated by photospheric continuum and show large excesses at 60um, represent a transition phase which follows an interruption of mass loss from the oxygen-rich phase and begins a new phase of the mass loss of carbon-rich material. Excesses at 60um in these stars are the emission from the residual of oxygen-rich material.

光学碳星的中红外能量主要来自光球,在60μm处存在超量发射,人们认为其演化阶段处在抛射富氧物质终止和新的富碳拱星壳层形成之间,其60μm超量发射就是富氧物质的残余效应。

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In other research, chondroitin is being investigated for use in several other conditions.

在其它研究,软骨素被调查用於几个其它情况。

They would make fun of him for having to work.

他们拿他的工作来开玩笑。

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