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The liver fibrotic model was induced by CCl4 i.p for 5wk. Telmisartan was given at the same time model establishment in each intervened group by administration lasted for 6wk. Decollate to get the blood of all rats after 7 weeks . ALT、AST and ALB of serum was detected by automatic biochemistry equipment. Hyaluronic acid was detected by ELISA detection. Liver and spleen was obtained to calculate the index. The liver pathological changes were observed in each group of rats after HE staining to evaluate the therapeutic effect of Telmisartan; TGF-β1、PPAR-γand PDGF of liver tissue was detected by the method of immunohistochemistry respectively; The mRNA expression of TGF-β1、MMP-1、TIMP-1、α-SMA、PPAR-γand iNOS was detected by RT-PCR detection, respectively.

腹腔注射CCl4制备SD大鼠肝纤维化动物模型,连续灌胃6周,处死动物取血,检测血清ALT、AST、ALB;ELISA法测定血清透明质酸;取肝、睥,并计算肝、脾指数,组织切片HE染色后进行组织病理学疗效评估;用SP免疫组化法测定肝组织TGF-β1、PPAR-γ及PDGF蛋白表达;半定量RT-PCR方法检测肝组织TGF-β1、MMP-1、TIMP-1、α-SMA、PPAR-γ和iNOSmRNA的表达。

aim to study the efficaciousness of wuling cap-sules for hepatic fibrosis in rats.methods rat models with hepatic fibrosis were induced by ccl4 compound factors and then treated with wuling capsules.pathology of liver sections,hyaluronic acid and procollagencontents in rat liver and serum were examined respectively.results pathological examinations showed that the liver cells of mod-el rats were injured seriously.collagen fibers proliferated and dissected hepatic lobules in model rats.wuling capsules could protect liver cells and reduce degrees of hepatic fibro-sis.the best effects were achieved at3.0g?

目的 研究五灵胶囊对大鼠肝纤维化的作用。方法采用以四氯化碳为主的复合因素致大鼠肝纤维化,观察五灵胶囊对肝组织病理学、肝组织和血清中羟脯氨酸、ⅰ,ⅲ型前胶原含量的影响。结果病理学检查显示,模型组大鼠肝细胞损伤严重,胶原纤维大量增生,形成假小叶。五灵胶囊组大鼠肝细胞结构破坏不明显,肝纤维化程度轻,在3.0g?kg-1 时治疗效果最好。

And HGF were reduced in mouse of liver metastasis with cancer, which may intervene the liver metastasis; Shensanqi extract had some definite function on the primary cancer of spleen and liver metastasis of rats with liver metastasis of cancer, the platelet exerted key functions in cancer hyperplasia, infiltration and metastasis.

18和HGF的水平降低,可能干预了肝转移的过程,参三七醇提液对荷瘤肝转移大鼠的脾脏原发肿瘤的生长和肝转移有一定抑制作用,血小板在肿瘤增殖、浸润和转移中起着重要作用。

Result] Under blood stasis, it can to some extent inhibit the production of primary cancer, the serum IL18 and HGF were reduced in mouse of liver metastasis with cancer, which may intervene the liver metastasis; Shensanqi extract had some definite function on the primary cancer of spleen and liver metastasis of rats with liver metastasis of cancer, the platelet exerted key functions in cancer hyperplasia, infiltration and metastasis.

结果]在血瘀状态下,可在一定程度上抑制原发肿瘤的生长,荷瘤肝转移小鼠血清IL18和HGF的水平降低,可能干预了肝转移的过程,参三七醇提液对荷瘤肝转移大鼠的脾脏原发肿瘤的生长和肝转移有一定抑制作用,血小板在肿瘤增殖、浸润和转移中起着重要作用。

At 8 weeks, the liver in the experimental group developed purple, seems wrapping with millets. Pathological sections showed punctiform or lamellar cellular necrosis, inflammatory cell infiltration around liver canaliculus, displaying early symptoms of liver fibrosis. At 12 weeks, the liver looks gray, seems wrapping with many types of millet.

实验组8周时,肝脏呈暗紫色,表面有轻微粟粒样改变,病理切片示:肝细胞点状及点灶状坏死,汇管区炎症细胞浸润,呈早期纤维化症状。12周时,肝脏呈灰褐色,有较明显粟粒样改变。

Experimental research indicates:QZZGX granule can treat alcoholic fatty liver and DL桬thionine aminoacid fatty liver of the mouse by adjusting metabolism of fat, descending the level of TG,Gn in the liver, improving liver function, anti梠xidat ion descending the content of oxyproling hydroxyproling and improving the level of NO in the body.

实验研究表明:该药对酒精性和乙硫氨酸脂肪肝大鼠通过调节脂肪代谢、降低肝内TG、Gn水平、对酒精性脂肪肝大鼠改善肝功能、抗氧化、降低羟脯氨酸含量和改善体内一氧化氮水平等途径达到治疗脂肪肝的目的。

Firstly,all patients have been excided the upper ductus choledochus,the liver gross duct,left right liver duct besides one centimeter of liver duct that lies upwards the hepatolith.Secondly, we have sutured the excided bile duct, which has been shaped acetabuliform,lifted one part of jejunums,intered non-port one subcuneously,and then inosculated gall with enteron by Roux-en-Y way.Lastly,we have partly excised the ill liver in regular way.Results 26 ones have been follow-up for 1~10 years.The rate is 81 percents,average for 6 years.

32例肝内胆管结石均接受皮下盲袢型胆肠吻合术,其中结石位于右肝7例(22%),左肝9例(28%),两肝均有16例(50%);结石合并肝胆管狭窄24例(75%),全部病例均切开胆总管上部、肝总管、左右肝管,并切开肝内胆管狭窄部以上1cm肝管,将切开的胆管做必要的缝合,形成碟状,取一段空肠上提,盲袢埋置皮下,再做胆肠Roux-en-Y吻合,病肝做规则性肝部分切除术。

The Ganzhiping capsule composed of Jianghuang Chishao Haizao Fuling and compositon E has the efficiency of soothing the liver to regulate the flow of vital energy, strengthen the spleen by oozing wet firmly of invigorating blood circulation etc. It can effectively prevent and cure the fatty liver and acute liver-damage and chronic hepatitis cause to liver fibrination in clinic.

肝脂平胶囊是由姜黄、赤芍、海藻、茯苓和提取物E提取研制而成,具有疏肝理气、活血化瘀、软坚散结、健脾渗湿的功效,可有效的预防和治疗临床上的脂肪肝和急性肝损伤及慢性肝炎引起的肝纤维化等症。

This review focuses on the current research progress of the liver cell differentiation source, and it also discusses the advantages and disadvantages of various hepatic stem cells and nonhepatic stem cells, expecting to provide a reference for liver cell source selection during tissue engineering, an adequate and suitable source for bioartificial liver and hepatocyte transplantation and to help to treat liver diseases.

本文着重论述了目前肝脏细胞的分化来源研究进展情况,并对各种肝源性和非肝源性干细胞的优缺点进行了讨论,以期为肝组织工程选择细胞来源提供参考,为生物人工肝、肝细胞移植提供充足、合适的细胞来源,协助治疗肝脏疾病。

Liver pain, or even death in cirrhotic ascites; Paragonimiasis infected cysts, child or adult worms in human tissues and organs within the transitional, If staying in the lung, patients would cough, chest pain and other discomfort, live in the brain occur in epilepsy, hemiplegia, live mainly in the liver to the liver, liver pain, will live in the subcutaneous form transitional mass or nodule; Fasciolopsiasis worm infection can suffer from abdominal pain, diarrhea, malnutrition, etc.; Angiostrongylus cantonensis larvae in human migration, lesions in the brain, can cause severe headache, nausea, vomiting, fever and neck hard, there will be serious paralysis, lethargy, coma or even death.

感染食源性寄生虫病后可出现不同的症状或体征:华枝睾吸虫病的危害主要是肝受损,轻症者可出现胃肠道不适症状,重者常有肝肿大、肝区疼痛、肝硬变腹水甚至死亡;感染肺吸虫囊蚴后,童虫或成虫在人体组织与器官内移行,若寄居在肺里,患者会出现咳嗽、胸痛等不适感觉,寄居在脑中则出现癫痫、偏瘫等情况,寄居在肝内主要表现为肝大、肝痛,寄居在皮下则形成移行性包块或结节;感染姜片虫后可出现腹痛、腹泻、营养不良等;广州管圆线虫的幼虫在人体移行,病变集中在脑组织,可引起剧烈头痛、恶心、呕吐、发热及颈硬等,严重者会出现瘫痪、嗜睡、昏迷甚至死亡。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

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You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?