the 1

Estrogen deficiency can increase the mRNA expression of MMP-1、MMP-3 and IL-1β in OA synovia tissue. Estrogen could inhibit the mRNA expression of MMP-1、 MMP-3 and IL-1β in OA synovia tissue. Progestin could even decrease this expression. Estrogen could slightly increase the mRNA expression of TIMP-1. It is suggested that low dose of estrogen supplement play a protective effect on OA cartilage, and progestin could increase this protective effect.

雌激素缺乏可使OA关节滑膜中MMP-1、MMP-3和IL-1β mRNA表达增加，雌激素对关节滑膜组织中MMP-1、MMP-3和IL-1β mRNA表达有抑制作用，孕激素可增强雌激素的这一抑制作用，雌激素对TIMP-1有轻度升高作用，提示低剂量雌激素对OA关节软骨有一定保护作用，而加用孕激素这一保护作用增强。

Ten novel derivatives of 1-phenyl-5-[5-(substituted anilinocarbonylmethylthio)-4-phenyl-1,2,4- triazol-3-ylmethylthio]-tetrazole were synthesized rapidly in high yields by the reaction of N--2-chloryacetanilide (3) with 1-phenyl-5-(5-mercapto-4-phenyl-1,2,4-triazol-3-ylmethylthio)-tetrazo- le (2) under microwave irradiation and phase transfer catalysis conditions.

采用微波和相转移催化法通过1-苯基-5-(4-苯基-1，2，4-三唑-5-巯基-3-甲硫基)四唑(2)与2-氯乙酰芳胺(3)反应高效、快速地合成了10种尚未见文献报道的1-苯基-5-[5--4-苯基-1，2，4-三唑-3-甲硫基]四唑。其结构经IR，1HNMR，13CNMR和元素分析表征。生物活性实验结果表明，该类化合物在较低浓度下部分化合物对小麦芽有很好的促进作用

Meta-analyses showed that the response rate of TP (topotecan + cisplatin) regimen had no significant difference compared with EP regimen (etoposide + cisplatin) with OR 0.83 and 95%CI 0.63 to 1.09, but myelo-suppression such as leucopenia and thrombopenia was more severe with TP regimen; the response rate of monotherapy with topotecan was similar with that of CE (carboplatin + etoposide) regimen with OR 0.59 and 95%CI 0.22 to 1.60; the response rate of TEP (topotecan + etoposide + cisplatin) regimen was comparable with that of EP regimen with OR 1.37 and 95%CI 0.82 to –2.28, but myelosuppression and anemia were more severe with TEP regimen; the response rate with OR 0.97 and 95％CI 0.60 to –1.57, median time to progression with WMD –2.32 and 95％CI –5.72 to 1.09 and median survival time with WMD –1.65 and 95％CI –7.13 to 3.83 of IV topotecan were similar to those of oral topotecan, while neutropenia was more severe with IV topotecan.

Meta分析结果表明，TP 方案与EP方案的反应率相似 [OR 0.83， 95%CI (0.63，1.09)]，但具有相对高的致血小板下降的骨髓毒性；单药拓朴替康与CE方案的反应率相似 [OR 0.59， 95%CI (0.22，1.60)]；TEP方案（拓扑替康＋足叶乙甙＋顺铂）与EP方案的反应率相似 [OR 1.37， 95%CI (0.82，2.28)]，TEP方案致化疗后重度白细胞下降、重度血小板下降、重度血红蛋白下降均高于EP方案；口服拓扑替康与静脉滴注拓扑替康的化疗后反应率 [OR 0.97， 95％CI (0.60，1.57)]、中位疾病进展期 [WMD –2.32， 95％CI (–5.72， 1.09)]、中位生存期 [WMD –1.65， 95％CI (–7.13，3.83)] 相似，口服拓扑替康化疗后重度中性粒细胞下降明显低于静脉滴注拓扑替康。

It's suggested that the genes carrying DFR-1、OsMlo-1 might play a role in disease resistance of rice. Based on the putative exons of DFR-1 and OsMlo-1, primers were designed. The experiment had been performed by RT-PCR to detect the expression of gene carrying DFR-1、QsMlo-1 in rice uninoculated, inoculated with Xanthomanas oryzae pv.

为了进一步研究水稻DFR-1、OsMlo-1所在基因的功能，在DFR-1、OsMlo-1假定的外显子上设计引物，通过RT-PCR技术，研究在接种白叶枯病菌株PX099以及接种稻瘟病菌株V86013前后，水稻品种IRBB13和水稻品种明恢63中DFR-1、OsMlo-1所在基因的表达。

The correlation analysis of chemical oxidation and vanadic oxidation methods also were made.Results The CV of determination total and direct bilirubin was 1.01%and 3.24%,between day was 1.58%and 2.31% respectively.

结果 总、直胆精密度分别为批内 CV1 。0 1 %与3 。2 4 %，日间 CV为 1 。5 8%与 2 。3 1 %；平均回收率总胆为 1 0 0 。8%，直胆为 1 0 4 。5 %，与日本钒酸氧化法共测 40例相关性为：总胆 Y =1 。0 5 X - 2 。5 3 ，r=0 。9992 ；直胆 Y =1 。1 9X - 4.5 6 ，r=0 。9985。

The sex ratios of female-male SSB from rice and Zizania fields were 1∶1.44 and close to 1∶1 respectively.

水稻田二化螟羽化成虫的雌雄性比为1∶1.44，而茭白田二化螟则接近1∶1。

Methods: Total 50 patients with hepatic tumors and tumor-like lesions performed perfusion imaging through 16-slice spiral CT. Including 17 liver cancers, 15 metastatic tumors, 16 angiomas, 1 hepatic inflammatory tumor and 1 simple cyst. 31 male patients and 19 female patients. The mean age of all 50 cases was 56.4±2.2 years. 15 cases of all 50 cases had medical record of hepatocirrhosis(13 liver cancers, 1 metastatic tumors, 1 angioma).

对50例肝肿瘤或肿瘤样病变行16层螺旋CT灌注成像扫描，其中肝癌17例，肝转移瘤15例，肝血管瘤16例，肝炎性假瘤1例及肝囊肿1例；患者男性31例，女性19例，年龄34~78岁，平均年龄56.4±2.2岁；其中15例患者存在肝硬化病史(13例肝癌，1例转移瘤，1例血管瘤)。

A one-step method for the synthesis of aromatic indolizine derivatives byintramolecular 1,5-dipolar cyclization reaction of 2-(2-arylethenyl)pyridinium N-ylidesin the presence of an oxidant has been studied for the first time. In the presence ofelectron-deficient olefins, however, 2-(2-phenylethenyl)pyridinium N-ylides underwent1,3-dipolar cycloadditions and then aromatized in situ by TPCD to produce indolizinederivatives, indicating 1,3-dipolar cycloaddition proceed more readily than 1 ,5-dipolarcyclization in these conditions. Pyridinium disubstituted N-ylides, readily obtainedfrom corresponding pridinium and β-chlorovinyl ketone, underwent thermalintramolecular 1,5-dipolar cyclization to give indolizine derivatives easily.Indolizinecarbaldehyde derivatives were synthesized starting from 2-pyridinecarbaldehyde in four-steps involving 1,3-dipolar cycloaddition reaction.

本文首次研究了2-(2-芳基乙烯基)吡啶N-叶立德在氧化剂存在下的分子内1，5-偶极环化反应，采用一锅法合成了中氮茚衍生物；研究了这些N-叶立德的1，5-偶极环化和1，3-偶极环加成反应的选择性，发现当有缺电子烯烃存在时，优先进行1，3-偶极环加成反应，而不再发生分子内1，5-偶极环化反应；由β-氯乙烯酮方便地得到了烯丙基N-叶立德，他们在加热时进行分子内1，5-偶极环化反应而得到中氮茚衍生物；由2-吡啶甲醛为起始原料，通过1，3-偶极环加成反应等四步反应，得到了重要的中氮茚甲醛衍生物，这些反应都具有条件温和和操作简便的特点，是合成中氮茚衍生物的新方法。

The depilating composition for less thiolase process and the piling depilation method therewith features that leather blank in 100 portions, proteinase in 0.1-0.6 portion, sodium sulphide in 0.1-0.8 portion, sodium chloride in 0.1-3 portions, surfactant 0.1-1 portion and hydrogen peroxide in 0-5 portions are dissolved or dispersed in water of 7-15 portions while adding rice bran in 1-4 portions and kaolin in 0.5-3 portions to form paste mixture; and the leather blank is then brushed manually to make the mixture adhered onto the inside of the leather blank, piled with inside to inside in hot room at 15-35 deg.c for 20-30 hr, and depilated manually after the hair becomes loose.

一种少硫酶脱毛组合物及其堆置脱毛方法，其特点是将皮坯100份、蛋白酶0.1-0.6份、硫化碱0.1-0.8份、氯化钠0.1-3份、表面活性剂0.1-1.0份和过氧化氢0-5份依次溶入或分散于水7-15份中，并加入米糠1-4份和高岭土0.5-3份的混合物调至糊状，用毛刷手工涂于浸水去肉后的皮坯的肉面上，要求涂糊均匀，然后肉面对肉面堆置，放入温度为15-35℃的温房内，时间约为20-30小时，待毛松动，进行手工推毛。

But Baumol has not reckoned with my contention that, all microeconomic price details aside, when we properly transform from rate-of-surplus-value accounting regime to actual rate-of-competitive-profit regime, we take an eraser and replace the a0-1(1+r*) m=1 relation that defines "the rate of surplusvalue, r*" by the alternative relation a0(1+R*)[I-a(1+R*)]-1 m=1 that defines the "competitive rate of profit, R*;" and literally nothing in the way of understanding of the latter's actual distribution relation is "revealed," is "uncovered" or is "laid bare" by the pre-eraser detouring.

但是鲍莫尔没有考虑到我的这一观点，将所有微观经济价格细节放在一边，当我们适当的将剩余价值率清算体制转化为实际的竞争利润率体制，我们就拿出一块橡皮并将a0-1(1+r*)m=1这一关系式替换成a0(1+R*)[I-a(1+R*)]-1m=1这一关系式，在关于后者的实际的分配关系的理解上，字面上没有任何东西被预先擦掉的弯路&揭示&、&揭露&或&暴露&出来。

They go to town. Would you just ask them?

他们在城里你能问他们吗？

Ossein pretreated for a2 weeks period exhibited the maximum% yield incase of bone gelatin, while the yield from intact skin was higher than that realized incase of de-scaled skin.

预处理时间达2星期的骨胶原表现出最高的骨明胶百分产量，然而从未处理鱼皮中得到的产率比去鳞的鱼皮得到的要高。