the 1

Results For the first primary lesions,most of them were stage IIa, including 12 invasive ductal caicinoma, 5DCIS, 2 invasive lobular caicinoma, a invasive carcinoma with cribriform pattern and 1 case mixed-cell carcinoma. On FFDM, 5 had microcalcification,13 were mass, 1 showed focal high attenuation and 2 were not detected. For the second primary lesions, most of them were stage 0, including 7 invasive ductal carcinoma, 12 DCIS ,1 invasive lobular carcinoma, 1 mixed-cell carcinoma.

结果；第一原发癌以Ⅱa期为主，浸润性导管癌12例，导管原位癌5例，浸润性小叶癌2例，浸润性筛状癌1例，混合细胞癌1例；5例以微钙化为主要表现，13例肿块，局部密度曾浓1例，2例未见异常；第二原发性癌以0期为主，浸润性异常癌7例，导管原位癌12例，浸润性小叶癌1例，混合细胞癌1例；11例以微钙化为主要表现，肿块3例，结构不良4例，局部密度曾浓1例，2例未见异常。

Using nuclear DNA C-values for 539 angiosperms in China, we examined the variation of these values among growth forms and taxonomic groups and the relationship of these values with invasiveness. Mean DNA C-value of the 539 angiosperm species was 4.06 pg. Mean DNA C-value was(1) significantly lower for woody species (1.84 pg) than for herbaceous species(5.02 pg);(2) significantly lower for 360 dicots (2.20 pg) than for 179 monocots (7.80 pg);(3) significantly lower for annuals (2.78 pg) than for perennials(6.65 pg);(4) significantly lower for 134 weed species (1.93 pg) than for herbaceous non-weeds (6.75 pg) and for several families that have an unusually high proportion of weed species;(5) significantly lower for 47 exotic weed species (1.76 pg) than for 134 native weeds (1.93 pg), but significantly lower than that of "non-weedy" herbaceous species (6.75 pg);(6) lower for weeds than for "non-weedy" species in same genus or family; and (7) in herbaceous species, generally lower for weedy compared to "non-weedy" species, with some exceptions such as Avena fatua, whose DNA C-value is as high as 14.15 pg, contrarily, and some "non-weedy" herbaceous species in Cruciferae and Cucurbitaceae with very low values.

统计了中国境内有分布的539种被子植物的DNA C-值，分析了它们在不同分类群、生活型、倍性、生活史类型以及在杂草和非杂草类群中的分布情况，主要结果如下：(1)539种被子植物DNA C-值平均为4.06 pg，其中木本植物的DNA C-值平均为1.84 pg，低于草本植物的平均值(5.02 pg)；(2)双子叶植物(360种)的DNA C-值平均为2.20 pg，极明显地小于单子叶植物(179种)的平均值(7.80 pg)；(3)1年生植物的DNA C-值平均为2.78 pg，明显小于多年植物的平均DNA C-值(6.65 pg)；(4)134种杂草的DNA C-值平均为1.93 pg，明显小于非杂草草本植物的平均值(6.75 pg)，含杂草较多的科，平均DNA C-值相对较小；(5)统计的47种入侵杂草的DNA C-值平均为1.76 pg，略小于134种杂草的平均DNA C-值(1.93 pg)，极显著地小于非杂草性草本植物(6.75 pg)；(6)以科为单位，不同科的DNA C-值存在着极大的差异；(7)DNA C-值与染色体倍性的关系并不明显，但是，随着倍性的增加，基因组变小；(8)在同一科、属中，与非杂草相比，典型杂草的DNA C-值往往偏小；(9)总体上杂草或杂草性强的植物，它们的DNA C-值比非杂草性植物的要小。

The final diagnoses of 12 patients were confirmed aschronic myeloid leukemia. The clinical diagnoses of another 2 pa-tients were acute myeloid leukemia, and the other 1 was secondarypolycythemia. Cytogenetically, the Ph~1 chromosomes were found among 11 of 12 pa-tients with CML, the mean of Ph~1 positive cells was 72.3%. The presenceof P...

在12例慢性粒细胞白血病中，11例Ph~1染色体为阳性(阳性率平均为72.3％)，1例为Ph~1阴性；2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5，其中1例还发现微小体；1例继发性红细胞增生症患者，70％的骨髓中期分裂细胞为Ph~1染色体阳性，并发现染色体碎裂细胞。

The final diagnoses of 12 patients were confirmed aschronic myeloid leukemia. The clinical diagnoses of another 2 pa-tients were acute myeloid leukemia, and the other 1 was secondarypolycythemia. Cytogenetically, the Ph~1 chromosomes were found among 11 of 12 pa-tients with CML, the mean of Ph~1 positive cells was 72.3%. The presenceof Ph~1 chromoso...

在12例慢性粒细胞白血病中，11例Ph~1染色体为阳性(阳性率平均为72.3％)，1例为Ph~1阴性；2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5，其中1例还发现微小体；1例继发性红细胞增生症患者，70％的骨髓中期分裂细胞为Ph~1染色体阳性，并发现染色体碎裂细胞。

Results l.Serum concentrations of VCAM-1 in PIH (93.39 + 57.3)ug/ml were higher than that in normal pregnant group. Serum concentrations of VCAM-1 in moderate(97.89 + 34.07)ug/ml and severe PIH(132.24 + 60.97)ug/ml were significantly higher than that in normal group.(P.05, P.01). There was no difference between serum levels of VCAM-1 mild PIH and normal pregnant group. 2.Serum levels of IL-6 in PIH group(102.17 ?48. 31)pg/ml were significantly higher than that in normal group(49.16 + 12.9)pg/ml.Serum levels of IL-6 in moderate(95.79+31.19)pg/ml and severe PIH( 127.27+11.3 8)pg,ml were significantly higher than that in normal group. There was no difference between serum levels of PIH in mild PIH (52.13 + 12.90)pg/ml and normal pregnant group. 3. In PIH group, serum concentrations of VCAM-1 correlate with the levels of IL-6,r=0.63. 4.The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group(100%) were significantly higher than that in PIH group.Theexpression of VCAM-1 in moderate PIH(37.50%) and sever PIH were lower than that in normal group.There was no difference between the mild PIH and normal group.Conclusions The increased levels of serum of VCAM-1 may participate in the process of vascular endothelium damages in PIH.

结果 1、妊高征组血清VCAM-1浓度为(93.39±57.3)μg／ml明显高于正常妊娠组(44.87±15.60)μg／ml，差别有显著性(P＜0.05)；中、重度妊高征组VCAM-1浓度分别为(97.89±34.07)μg／ml和(132.24±60.97)μg／ml，与正常妊娠组比较，差异有显著性(p＜0.05)和非常显著性(P＜0.01)；轻度妊高征组VCAH-1为(48.46±15.60)μg／ml与正常妊娠组比较，差异无显著性(P＞0.05)。2、妊高征组血清IL-6含量为(102.17±48.31)pg／ml，明显高于正常妊娠组(49.16+12.9)pg／ml，差异有非常显著性(P＜0.01)；中、重度妊高征组IL-6含量分别(95.79±31.19)pg／ml和(127.27±11.38)pg／ml，与正常妊娠组比较，差异有显著性(P＜0.05)和非常显著性(P＜0.01)；轻度妊高征组IL-6含量为(52.13±12.90)pg／ml与正常妊娠组比较，差异无显著性(P＞0.05)。3、VCAM-1与IL-6水平呈明显正相关，r=0.63(P＜0.01)。4、子宫胎盘床螺旋动脉滋养细胞VCAM-1表达，正常妊娠组都存在阳性表达(阳性表达率100％)，妊高征组有10例阳性表达阳性表达率为叩们，差别有非常显著性河＜0.01L 中、重度妊高征组阳性表达率分别为37、50％和0，与正常妊娠组比较，差别有显著性河＜0.05）和非常显著性汀＜0.01太轻度妊高征组阳性表达率为83.33凡与正常妊娠组差别无显著性问＞0.05）。

The new synthetic technology of some important anthraquinone intermediates derived from 1-amino- anthraquinone, l-amino-4-hydroxy-anthraquinone, l-amino-4-bromo- anthraquinone-2-sulfonic acid, 1,5- and 1,8 dinitro- anthraquinone, have been studied.

本文研究了几种重要的由1-氨基蒽醌衍生的蒽醌型中间体：1-氨基-4-羟基蒽醌、1-氨基-4-溴蒽醌-2-磺酸和1，5-及1，8-二硝基蒽醌的合成化学，在此基础上开发了上述中间体的合成新技术。

objectivein order to study il-1βand tgf-β1 have what effects on sd rat chondrocyte cell.methondsdifferent dosis of il-1βand tgf-β1 was used to deal chondrocyte cell 48 hours.then aggrecan and collagen ii of those celluar and the control group were detected by immune-histochemistry.

目的：研究人白细胞介素-1β（il-1β）和转化生长因子-β1(tgf-β1)对体外培养的sd大鼠肋软骨细胞功能的影响。

Methods: Foty healthy New Zealand white rabbits were randomly divided into four groops. Control groop was fed with normal diet for 10 weeks, model groop was fed with 1.5% cholesterol diet plus normal diet; APS groop was fed with 1.5% cholesterol plus 12.0mg/kg APS plus normal diet; Captopril groop was fed with 1.5% cholesterol plus 15.0mg/kg Captopril plus normal diet. After ten weeks' experiment, the concentration of each group's Triglyceride, Total Cholesterol, High Density Lipoprotein Cholesterol, C Reactive Protein, Nitric Oxide, Maleic Dialdehyde and Endothelin-1 were measured, so was the activity of superoxide dismutase.

将40只雄性新西兰兔随机分为4组，每组10只，对照组餵普通饲料；模型组：普通饲料加质量分数为1.5%的胆固醇餵养；黄芪多糖组：普通饲料加质量分数为1.5%的胆固醇餵养，同时腹腔注射APS(12.0mg/kg)；卡托普利组：普通饲料加质量分数为1.5%的胆固醇餵养，同时灌喂卡托普利(15.0mg/kg)；10周后，测定各组空腹血清或血浆三脂酰甘油、总胆固醇、高密度脂蛋白胆固醇、一氧化氮、内皮素-1(ET-1)、丙二醛、C反应蛋白含量以及超氧化物歧化酶活性，并计算主动脉内膜粥样斑块面积。

The optimum synthetic conditions of hexadecanoic acid diethanolamide used two-step method are as follows:(1)reaction temperature was 140℃, reaction time was 4.5hours and molar ratio of hexadecanoic acid to diethanolamide was 1:1.15.(2)reaction temperature was 80℃, molar ratio of hexadecanoic acid to diethanolamide was 1:1.55 and mass concentration of the catalyst was 0.8%, reaction time was 3 hours.

二步法合成十六酸二乙醇酰胺最佳合成工艺为：(1)反应温度140℃、反应摩尔比n十六酸∶n二乙醇胺=1∶1.15、反应时间4.5h；(2)反应温度80℃、反应总摩尔比n十六酸∶n二乙醇胺=1∶1.55、催化剂用量0.8%、反应时间3h。

The distributions of Hup A into rat brain tissues following intranasal dosing were compared with those after intravenous and intragastric dosing by tissue homogeneization.

结果大鼠鼻腔给药血浆AUC0→6h为静注的0.94倍，但脑脊液AUC0→6h为静注和灌胃的1.3和2.3倍；大鼠鼻腔给药后大脑、海马、小脑、左右嗅球的AUC0→6h分别为静注的1.5，1.3，1.0，1.2和1.0倍，为灌胃的2.7，2.2，1.9，3.1和2.6倍。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。