the 1

Grinding machine, 1 set Plane Grinding machine, 3 sets EDM, 1 set CMM, 1 set universal tool microscope, 1 set cutter aligner, 1 set roughness instrument, etc., much of equipments are the most advanced in domestic.

主要 设备有：加工中心9台（FV-800A 6台、QM-800A 1台、QM-22T 1台、卧式加工中心1台）、数控车床6台（FTC-20 2台、FTC-10 2台、FTC-30 1台、FTC-150 1台）、外圆磨一台、平面磨一台、慢走丝线切割机一台、快走丝线切割机一台，电火花成形机（MOND030）、三维坐标测量仪（GALAXY/SCICNC）、万能工具显微镜（19JC），对刀仪、粗糙度仪等。

Results: In the period of 1993-2000, there were 1 264 neural tube defects among 1 189 126 total births in 30 counties/cities in China. The overall neural tube defects rate was 10.63 per 10 000 births, and rates were higher (18.99 per 10 000 births) in the year 1993, lower (6.05 per 10 000 births) in 1998. The prevalence rates of anencephaly, spina bifida and encephalocele were 4.71 , 4.39 and 1.53 per 10 000 births respectively.

结果 ：在 1 993～ 2 0 0 0年间，共监测到 1 1 891 2 6个活产儿和死胎、死产儿出生，其中有明确诊断的神经管畸形儿 1 2 6 4例；总出生人群中的神经管畸形率为 1 0 。6 3/ 1 0 0 0 0 ，1 993年的畸形率最高( 1 8.99/ 1 0 0 0 0 )，1 998年最低( 6 。0 5/ 1 0 0 0 0 )；无脑儿、脊柱裂和脑膨出在每 1 0 0 0 0个出生儿中的患病率分别为 4 。71、4 。39和 1 。53。

Results: The mean recovery rates of Aminopyrin, Antipyrine and Barbitial were 100.0%, 100.1%and 100.4%with RSD 1.6%, 1.3%and 1.1%(n=6),respectively.

结果：氨基比林，安替比林和巴比妥的平均回收率分别为100.0%，100.1%和100.4%，相对标准差分别为1.6%，1.3%和1.1%(n=6)。

The Pb-Pb isochron of metamorphic argillite in Shuangqiaoshan Group is 1 490±68 Ma, while the Nd mode ages of Zhanggongshan Group, Shuangqiaoshan Group, Chenglang Group and Xiushui Group are 1.57 Ga, 1.89 Ga, 1.77 Ga, 1.60 Ga,respectively, less than 1.6-1.9 Ga, which suggest that they formed in Middle Proterozoic Subera.

研究结果还显示，双桥山群变质泥质岩的Pb-Pb等时线年龄为（1 490±68）Ma，而障公山群、双桥山群、程浪群和修水群的钕模式年龄分别为1.57 Ga、1.89Ga、1.77Ga和1.60 Ga，均分布在1.5～1.9 Ga之间，表明这些地层的形成年龄应小于1.9 Ga，是中—晚元古代的产物，同时表明扬子古陆南缘存在古元古代的基底。

Under soil water stress conditions, the photosynthesis rate, water useefficiency and light compensation point of Atriplex canescens obviouslyreduced, and its dark respiration rate weakened. In the treatments in July, theaccumulative and average value of daily Pn from high to low is: light soil water stress＞no soil water stress＞medium soil water stress＞heavy soil water stress, the valueare 7.162μmolm~(-2)s~(-1)、6.106μmolm~(-2)s~(-1)、6.103μmolm~(-2)s~(-1) and 1.761μmolm~(-2)s~(-1), respectively. In the treatments in August, the accumulative and average value ofdaily Pn from high to low is: light soil water stress＞medium soil water stress＞heavy soil water stress＞no soil water stress, the value are 7.378μmolm~(-2)s~(-1)、4.738μmolm~(-2)s~(-1)、1.794μmolm~(-2)s~(-1) and 1.705μmolm~(-2)s~(-1), respectively.

在土壤水分胁迫下四翅滨藜的净光合速率、水分利用效率、和光补偿点显著降低，暗呼吸速率减弱。7月份各处理Pn全天的累计值和平均值的大小顺序为：轻度土壤水分胁迫＞无土壤水分胁迫＞中度土壤水分胁迫＞重度土壤水分胁迫，它们的值分别为：7.162μmolm~(-2)s~(-1)、6.106μmolm~(-2)s~(-1)、6.103μmolm~(-2)s~(-1)和1.761μmolm~(-2)s~(-1)。8月份各处理的Pn全天累计值和平均值的大小顺序为：轻度土壤水分胁迫＞中度土壤水分胁迫＞重度土壤水分胁迫＞无土壤水分胁迫，它们的值分别为：7.378μmolm~(-2)s~(-1)、4.738μmolm~(-2)s~(-1)、1.794μmolm~(-2)s~(-1)和1.705μmolm~(-2)s~(-1)。9月份四翅滨藜的Pn变化趋势于8月份的变化曲线基本相似，唯一不同的变化就是各个处理的Pn比8月份的要高，这可能于9月份气温降低，湿度增大有关。

To obtain the best nutritional quality, the optimum nitrogen application is 125.8kg/hm~2 under middle density, during different development stage, the best C/N value were respectively 1.35-1.40, 1.17-1.25, 1.02-1.03, 0.62-0.71, 1.55-1.72, 0.98-1.02.8, Consequently, to obtain the unification between high yield and good quality, under the conditions of this study the optimum plant density is 60000 plant/hm2, the optimum nitrogen application is 120kg/hm2 to 180kg/hm2 under this density, it was obtained that at five-leaf, seven-leaf, ten-leaf, silking, lid after silking and harvest stage, the best C/N value were 1.27-1.63, 0.80-1.38, 0.81-1.07, 0.62-0.90, 1.39-1.72, 0.98-1.17, respectively.

在各生育时期适宜叶片碳氮比值分别为：1.35～1.40、1.17～1.25、1.02～1.03、0.62～0.71、1.55～1.72、0.98～1.02。 8、综合各因素，要达到甜玉米高产优质的统一，本试验推荐种植密度为60000株/hm~2，中密度下适宜施氮量为120～180kg/hm~2，叶片碳氮比值在五叶展、七叶展、十叶展、吐丝期、吐丝后11天、收获期动态变化为：1.27～1.63、0.80～1.38、0.81～1.07、0.62～0.90、1.39～1.72、0.98～1.17。

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

After adjustment for body mass index and other potential confounders, the relative risks of total mortality were 1, 1.28 (95% confidence interval , 1.04-1.58), 1.40 (95% CI, 1.14-1.72), 1.54 (95% CI, 1.26-1.88), and 1.95 (95% CI, 1.60-2.38) across the lowest to the highest waist-hip ratio quintiles.

在调整体重指数和潜在的混杂因素后，全部死亡率的相对危险在参照组为1，在从最低到最高的腰臀比值五等分后的的组中分别为：1.28 (95%可信区间， 1.04-1.58)， 1.40 (95%可信区间， 1.14-1.72)， 1.54 (95%可信区间， 1.26-1.88)，和 1.95 (95%可信区间，1.60-2.38)。

By further comparing the retention time of the profounds and that of the impurities,the main impurities in triadimefon technical was conformed as following:First, 1-(4-bromophenoxy)-3,3-dimethyl-1 -(1H-1,2,4-triazol-1 -yl)-2-butanone;Second, 1-(2,4-dichlorophenoxy)-3,3-dimethyl-1 -(1H-1,2,4-triazol-1 -yl)-2-butanone;Third, 1,1 -bis(4-chlorophenoxy)-3,3 -dimethy 1-2-butanoneour conclusion is conformed right.

再经过化合物的保留时间与杂质保留时间的比照，证实了三唑酮原药中的主要杂质是：杂质Ⅰ：1-(4-溴苯氧基)-3，3-二甲基-1-(1H-1，2，4-三氮唑-1-基)-2-丁酮；杂质Ⅱ：1-(2，4-二氯苯氧基)-3，3-二甲基-1-(1H-1，2，4-三氮唑-1-基)-2-丁酮；杂质Ⅲ：1，1-二(4-氯苯氧基)-3，3-二甲基-2-丁酮。

After experiments, we got some results as the following:1.Induced by semi-conductor laser, solid DNA changes as below: 1the deoxyribose-phosphate backbone vibrations in DNA decreasing, these bands are at 884~890cm~(-1),1112cm~(-1) and 1168cm~(-1). 2 deoxyribose and C-O stretch vibration in d increasing, there are new bands occurring at 1436cm~(-1) and 1072cm~(-1), the intensities of these bands at 1466cm~(-1) and 1030cm~(-1) increase.

通过实验研究，得到如下一些结论： 1、固体DNA经半导体激光器照射后，可以导致以下变化：(1)DNA中脱氧核糖磷酸主链振动减弱，包括在884～890cm~(-1)、1112cm~(-1)和1168cm~(-1)处的谱带；(2)脱氧核糖以及d中CO的伸缩振动增强，在1436cm~(-1)和1072cm~(-1)处出现了新的谱带，在1466cm~(-1)和1030cm~(-1)处的谱带强度增强；(3)各碱基的振动频率和相对强度都发生了很大的变化，碱基中羰基的伸缩振动显著增强，在1650cm~(-1)和1670cm~(-1)处出现了新的谱带，在1710cm~(-1)处的谱带强度显著增强。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。