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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Mr Ensaite expresses we or the contriver that want pair of favour case Er enough devoir -- it is you , still be you , church people returns start again from terminus

我们还是要对恩格尔的发明者恩思特先生表示足够的敬意--是你，还是你，教会了人们从终点再回到起点

Result:MRI could find the level of conus tip and the pathological changes of filum,terminus,spinal lipoma,spinal cord and spinal column.

结果：MRI可详细了解脊髓圆锥的位置、终丝、椎管内外脂肪瘤、脊髓脊膜以及脊柱等的各种病理变化。

The cDNA has 752bp and encodes a protein of 216 amino acids. Thenascent Src l contained a signal peptide of 19 amino acids, a propart of 19 amino acidsand a 178-amino-acid mature Src l. The characteristic amphiphilic α-helix of cytolysin islocated at the N-terminus of the mature Src l.

根据文库的EST序列设计引物，从玫瑰红绿海葵克隆到一全长cDNA序列，命名为Src I，利用生物信息学方法对其进行了分析，结果表明，该cDNA序列编码一个216个氨基酸的海葵细胞毒素前体蛋白，它包括19个氨基酸的信号肽、19个氨基酸的propart motif和178个氨基酸的成熟蛋白。

The fragment encoding the polypeptide of wheat MLO protein C terminus located in cytoplast was cloned into the vector pET-30a and expressed in the strain BL21 of E coli.

本研究将编码小麦MLO蛋白羧基端约130个氨基酸多肽的基因片断克隆到表达载体pET-30a中，在大肠杆菌中表达了该多肽的融合蛋白。

Objective To express the functional domain at C-terminus of Clostridium difficile cytotoxin B and lay a foundation of developing effective vaccine against infection with Clostridium dificile and diagnostic antigen.

目的 表达并纯化艰难羧菌细胞毒素B羧基末端功能区片段，为制备高效防治艰难羧菌感染的疫苗和诊断抗原奠定基础。

Also not with enough time is frightened me, the tight seal gate opens in front of me and reveals extended declivity, terminus has not resembled stone steps.

脑海内响起一连串的奇异的铃响声。声音并不是从耳里传来，而是无中生有地在我脑海里响起，就像来自其它多维时空。

Second-stage juvenile rectum usually not dilated, tail hyaline terminus definite or not , digitate , with bluntly-round tip.

二龄幼虫直肠有的膨大明显，但在大多数标本中看不到膨大，尾透明末端界限明显或不太明显，指状，末端钝圆。

The signal peptides of chicken Igλ light chain and murine plasmingen were fused to the GFP N terminus using site-directed mutagenesis to construct the vectors with signal sequence, pEGFP-SPc and pEGFP-SPm. The chicken Igλ gene was inserted into the two vectors with signal sequence after double enzyme cutting.

分别将鸡Igλ轻链信号肽、小鼠纤溶酶原信号肽与pEGFP-C1载体的绿色荧光蛋白N端融合，产生带有信号肽的中间载体pEGFP-SPc和pEGFP-SPm。

The general route of the Great Indian Peninsula Railway is as follows:- Leaving Bombay, it passes through Salcette, crossing to the continent opposite Tannah, goes over the chain of the Western Ghauts, runs thence north-east as far as Burhampoor, skirts the nearly independent territory of Bundelcund, ascends to Allahabad, turns thence eastwardly, meeting the Ganges at Benares, then departs from the river a little, and, descending south-eastward by Burdivan and the French town of Chandernagor, has its terminus at Calcutta.

这儿，概括地介绍一下大印度半岛铁路沿线的重点站。火车离开孟买岛穿过萨尔赛特岛，进入位于塔那前面的大陆腹地，穿过西高止山脉向东北直达布尔汉普尔，再穿过差不多可以算是独立的本德尔汗德上邦的领地，北上到阿拉哈巴德，再向东进，在贝拿勒斯与恒河相遇，然后离开恒河不远向东南下行经过布德万和法属殖民地昌德纳戈尔直奔终点站加尔各答。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。