查询词典 taxol

As a result, the isolation of genes involved in Taxol biosynthesis is an essential prerequisite, not only for investigation on mechanism of Taxol anabolism and elicitors'function but also for successful manipulation of Taxol anabolism at molecular level.

上述工作的第一步即需要探测和分离紫杉醇生物合成相关基因或主基因，这是研究紫杉醇合成代谢规律和诱导子作用机理的重要切入点，也是实现分子水平上的代谢调控的切入点。

Based on the detailed analysis of a variety of factors affecting stability of taxol production in Taxus cells, it was discovered that initial cell density and the relevant concentrations of substrates, elicitors and precursors significantly affected stability of taxol production; farther study showed that addition of elicitors at appropriate cellular state was the key to steadily improve taxol yield, especially, the proper cellular state was at the end of lag phase and at the beginning of the stationary phase, which was also proved by the cellular ultrastructure.

对影响红豆杉细胞紫杉醇产量稳定性的各类因素进行详细分析，发现细胞的接种密度以及与之相适应的培养基的基质浓度、诱导子浓度和前体浓度是影响紫杉醇产量稳定的重要因素；进一步研究发现，选择细胞处于合适的状态时加入诱导子是稳定提高紫杉醇产量的关键，细胞合适状态特别是延迟期末和稳定期初最合适，细胞状态的超微结构观察结果也证明了这一点；同时研究发现采用合适的同步化处理获得的细胞初始周期时相加入诱导子与紫杉醇产量稳定密切相关，且以低温同步化处理得到的细胞周期的分裂中期相的细胞加入诱导子不仅大大提高了紫杉醇的产量，而且诱导子加入时间大大缩短，有利于大大提高紫杉醇生产率。

This C-ring synthon willprove be a versatile intermediate for the construction of taxol skeleton analogues.

该C环片断可用来作为合成Taxol骨架类似物的重要中间体。

Paclitaxel, mostly described by the tradename Taxol, is a diterpenoid that can be found in the bark and needles of different Taxus trees.

紫杉醇，通常商品名为Taxol紫杉醇，是一种二萜类化合物，存在于紫杉属树木的树皮和针叶中。

The results showed that precursor feeding (phenylanine, sodium acetate and benzamide) and mixed sugar as production medium resulted in significant increase of taxol production not only in the one-liquid-phase cultures of Taxus chinensis var. mairei but also in the two-liquid-phase cultures. And the integrated function of precursor feeding and mixed sugar in the two-liquid-phase cultures gave more significant increase of taxol production significant increase of taxol production, which was four times more than that of the control (the one-liquid-phase culture without precursors and mixed sugar).

结果表明前体饲喂（苯丙氨酸，醋酸钠和苯甲酰胺）和蔗糖与麦芽糖配伍作为生产培养基糖源不仅对红豆杉细胞悬浮培养，而且对其两液相培养的紫杉醇产量提高均有明显的促进作用，与对照组相比，在南方红豆杉细胞两液相培养中，采用前体饲喂和蔗糖与麦芽糖配伍作为生产培养基糖源，紫杉醇产量提高4倍多。

Taxol,a diterpene compound derived from Taxus brevifolia,is oneof the most effective anti-cancer natural chemical drugs.It is clinically used for thetreatment of ovarian and breast cancers.

紫杉醇(taxol，paclitaxel)是一种从紫杉中分离出来的双萜类化合物，是目前已知的最有效的抗肿瘤天然化学药物之一，适用于卵巢癌和乳腺癌等的临床治疗。

Among the most common excretive cytokines, increasing of GRO, IL-6, IL-8 and TIMP2 might be related to drug-resistance of ADM and CBPDA in ovarian cancer cell, while IL-6 and IL-8 might also be related with drug resistance of TAXOL and VP16. The different types of ovarian cancer cell might have roughly similar excretive cytokines-induced mechanism of drug resistance.

在常见分泌型细胞因子中，GRO，IL-6，IL-8和TIMP-2升高与一线化疗药ADM和CBPDA耐药性相关，IL-6，IL-8与二线化疗药TAXOL，VP16耐药性相关，不同来源的卵巢癌细胞分泌型蛋白作用机制可能存在共同的上述几种蛋白参与的调节体系。

The invention relates to a new strain producing taxol and a taxol preparation method. The taxol is a diterpenoid alkaloid drug which is extracted from taxaceae plants and has a plurality of anti-tumor effects. Taxus, also known as yew, is a prehistoric plant with a history of 0.2 billion years and is a rare plant species with low growing speed; the biological characteristics of the taxus have high demand on the ecological environment; the natural renewal ability is poor, so the amount of the species is very limited, belonging to an endangered protection plant with limited resource, thus, scientists at home and abroad actively research and develop new taxol sources. The new strain for producing the taxol of the invention is the strain which is first separated from the bark of T.cuspidate Sieb.

产紫杉醇的新菌种及其选育和制备紫杉醇的方法，紫杉醇是从红豆杉属植物中提取出来的具有多种抗肿瘤疗效的二萜生物碱类药物，由于红豆杉，又名紫杉，是两亿年前的史前植物，是珍稀树种，生长速度缓慢，并且其生物学特性对生态环境要求较高，天然更新能力差，所以种群数量极为有限，属濒危保护植物，资源十分有限，因此，国内外学者都在积极地研究开发紫杉醇的新药源，本发明产紫杉醇的新菌种，所述的新菌种为从东北红豆杉T.cuspidate Sieb。

The results showed the appropriate concentration of taxol (10 μM) or taxotere (35 μM) activate the influxes of H+, ROS accumulation, PAL activity and biosynthesis of taxol, as well as apoptosis, however, the high concentration taxol or taxotere (140 μM) did not show above results. Ten plots of protein were only observed in taxol-induced cells and there were differences at expression level of some plots between control and taxol-induced cells using two dimension electrophoresis, which reflect those differential protein were highly relevant to signal moleculars of cell defense responses, suggesting cell apoptosis and taxol biosynthesis might be parallel or two events in the same pathway of defense responses.

采用二维凝胶电泳技术，分析了taxol诱导细胞产生早期防御响应的蛋白表达差异，发现taxol诱导了10个新蛋白点的表达，其中一些新蛋白点的分子量与细胞信号分子G-蛋白、Ca2+依赖蛋白激酶的分子量接近。

In the last part, we fulfilled the synthesis of taxol CB-ring system.

第三部分我们完成了官能化的Taxol CB环片断的合成。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。