查询词典 tautomer

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

OH -Tautomer more stable and predicted to predominate in gas phase.

羟基互变异构体更加稳定和预测天然气占主导的阶段。

There is little evidence to support the general supposition that the NH -tautomer is generally favoured see Wang et.

很少有证据支持的一般假定的新罕布什尔州，互变异构体普遍赞成

The dioxo tautomer of Uracil is the most stable in the natural status.

正常情况下，脲嘧啶在双螺旋结构中主要以酮式的结构存在。

General Statement一般性发言 OH -Tautomer more stable and predicted to predominate in gas phase.

羟基互变异构体更加稳定和预测天然气占主导的阶段。

Two potential wells are found. One corresponds to the normal cytosine, while the other corresponds to its imino tautomer.

发现有两个势阱：其中一个对应正常的胞嘧啶，而另一个则对应它的顺式亚胺式互变异构体。

The results showed that the dithione R is the most stable tautomer of all the tautomers in the form of isolated or hydrated isomers.

计算结果表明， 2，6-二巯基嘌呤无论是孤立分子还是一水合物，其二硫酮式R是最稳定异构体。

Then, by using another tautomer (2H-indazole form), all of the above processes were repeated to investigate the effect of tautomerism upon the QSAR modelling.

对所有化合物采用另一异构形式重复上述过程，以探讨互变异构对QSAR建模的影响。

The absorption cross section,σ_p, for λ=337.1 nm and fluorescence quantum yield,φ, of each tautomer are quite different.

各种异构体对λ=337.1 nm激发光的吸收截面σ_P和其荧光最子产额φ各不相同。

The effect leading to mutation occurs during DNA replication when a rare tautomer in the template strand matches with a noncomplementary base.

当模板链中的稀有同分异构体与非互补的碱基配对时，则在DNA复制过程中就会产生导致突变的影响。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！