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Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Osteoarthritis is a degenerative disease that disunites the extra cellular matrix of articular cartilage and is arduous to cure because cartilage is a complex and nonvascular tissue. Treatment of OA has targeted modifiable reagent to be the connective tissue structure-modifying agents and disease- modifying osteoarthritis drugs, such as hyaluronic acid or modified tetracycline.

退化性关节炎是一种缓慢渐进式的退化性疾病，目前治疗关节炎药物的研究重点，在於进一步修饰已知传统药物之官能基，使其成为具有改善连结组织结构以及减缓关节炎症状之药物。

Human chorionic gonadotropin, a targeted use, treat oligospermia and male sexual dysfunction, but the diagnosis must be clear, indeed indications to the application.

人绒毛膜促性腺激素，有针对性地使用，可治疗少精症和男子性功能障碍，但一定要明确诊断，确属适应症才能应用。

This is one area where foreign companies should expect to be targeted and "outed" if they do not comply.

如果不遵守规定，这是外企应当预计到将被锁定和&驱赶出局&的一个方面。

The composite design strategy we put forward is the urban design strategy and its form expression targeted at ground, overground and underground space, which expanded the intension and extension of markers and enabled them to have stronger place adaptability and visual marking nature.

我们提出的是复合设计策略，是针对地面、地上、地下空间的城市设计策略与形式表达。扩展了标志物形式的内涵与外延，使其具有更强的场地适应性与视觉标志性。

In this paper,we provided a review in following aspects:the synovial angiogenesis process,influencing factors,and treatment of RA targeted on pannus and synovial angiogenesis,with the view to provide ideas and reference for the treatment of RA.

本文从滑膜血管生成过程及其影响因素以及以滑膜血管或血管翳为靶标的RA治疗策略3个方面进行了初步的阐述，以期为RA临床的防治研究提供思路和参考。

Because of the variability within the patellofemoral pain population, researchers are also interested in more targeted interventions based on an individual patient's set of symptoms.

因为髌骨疼痛族群中的差异，研究者们也对於根据病患症状量身订作的介入感到兴趣。

Rab27A was found to be targeted to diffuse in cytoplasm in three cancer cell lines and particularly concentrated in perinuclear in MDAMB231 and MDAMB435 cells.

本文检测了Rab27A基因在人乳癌细胞中的表达及定位情况，以期进一步研究其对乳癌细胞生物学特性的影响，现将结果报告如下。

Targeted phycological education should be used to improve the students' mental health level.

应有针对性地进行心理卫生教育，提高学生的心理健康水平。

We show that tumors displaying polysomy 17 in the absence of HER2gene amplification resemble more HER-2–negative than HER-2–positive tumors. These findings highlight the need for clinical trials to investigative whether polysomy 17 tumors benefit from HER-2–targeted therapy.

在他看来，若要进一步改进乳腺癌靶向治疗的患者选择和转归，遗传和药理学基础研究、已有研究数据再评价以及肿瘤早期HER2变异研究需要齐头并进。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。